Opportunity Information: Apply for RFA RM 16 022
Apply for RFA RM 16 022
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310.
- This funding opportunity was created on Sep 16, 2016.
- Applicants must submit their applications by Nov 28, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $400,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The funding opportunity "Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (U01)" (RFA-RM-16-022) is a National Institutes of Health (NIH) cooperative agreement designed to push glycoscience tools into broader, routine use across biomedical research. It sits under the NIH Common Fund program called "Accelerating Translation of Glycoscience Integration and Accessibility," which focuses on making carbohydrate (glycan) research more practical for the many scientists who are not specialists in glycobiology. The basic premise is that glycans are deeply involved in health and disease, but they are often difficult to study because their structures are complex, diverse, and not as straightforward to measure or manipulate as genes and proteins. This initiative aims to close that gap by supporting the creation of new technologies that are easier to access, more affordable, and more usable by typical biomedical labs.
The scientific emphasis is on tool and technology development that enables researchers to identify glycans, track them in biological systems, manipulate them experimentally, and analyze their functions. In practical terms, that points to innovations that improve glycan detection, structural characterization, labeling and imaging approaches, enrichment and separation methods, glycoengineering or perturbation strategies, and analytical platforms that connect glycan changes to biological outcomes. The program is geared toward translational impact in a broad sense: not necessarily clinical trials, but making it possible for many areas of biomedicine to incorporate glycan-related measurements and experiments as a standard part of studying cells, tissues, pathogens, immunity, cancer, development, and other disease-relevant processes. A central theme is lowering the barrier to entry so that scientists who "might not otherwise conduct research in the glycosciences" can still study carbohydrate structure and function with reliable, well-supported tools.
Mechanistically, this is a cooperative agreement (U01), meaning NIH staff are expected to have substantial involvement compared with a typical investigator-initiated grant. U01 awards are often used when the agency anticipates active partnership, coordination, milestone-driven progress, or harmonization with a broader program. That fits the stated goal of building enabling technologies intended for wide adoption, where coordination, dissemination, usability, and alignment with program objectives can matter as much as the underlying invention. The activity category is Health, and the associated CFDA number is 93.310, reflecting its placement within NIH health research support.
From a funding and scale standpoint, the opportunity listed an award ceiling of $400,000 and anticipated about three awards. The posting shows a creation date of September 16, 2016, with an original closing date of November 28, 2016. Those details indicate a targeted, competitive call intended to seed a small set of projects with the potential to produce broadly enabling glycoscience technologies rather than funding a large number of exploratory studies. Given the focus on accessibility and affordability, successful projects would be expected to deliver outputs that the community can actually adopt, such as robust workflows, platforms, reagents, software, standards, or integrated methods that improve reproducibility and reduce specialized expertise requirements.
Eligibility was intentionally broad, reflecting the tool-building, interdisciplinary nature of the program. Eligible applicants included multiple levels of government entities (state, county, city/township, special districts), independent school districts, public and private institutions of higher education, federally recognized tribal governments and other tribal organizations, public housing authorities/Indian housing authorities, nonprofits with or without 501(c)(3) status, for-profit organizations (other than small businesses), and small businesses, plus additional categories as clarified in the full announcement. This wide eligibility makes sense for a technology-focused initiative where innovations might come from academic labs, research institutes, biotech or instrumentation companies, or hybrid partnerships that combine engineering, chemistry, analytics, computation, and biology.
Overall, the opportunity is best understood as an NIH Common Fund push to make glycan science easier to do, easier to afford, and easier to integrate into mainstream biomedical research. Instead of asking applicants to answer a single biological question, it asks them to build the practical capabilities that let many other researchers ask and answer glycan-related questions in their own disease areas. The intended payoff is a step change in how routinely glycans can be measured and manipulated, leading to faster and deeper insight into the roles carbohydrates play in health and disease.
Frequently Asked Questions (FAQs)
What is the full title of this funding opportunity?
The opportunity is titled "Novel and Innovative Tools to Facilitate Identification, Tracking, Manipulation, and Analysis of Glycans and their Functions (U01)" and is identified as RFA-RM-16-022.
Which agency is offering this grant?
This is a National Institutes of Health (NIH) funding opportunity.
What NIH program is this opportunity associated with?
It sits under the NIH Common Fund program "Accelerating Translation of Glycoscience Integration and Accessibility," which is aimed at making glycoscience tools and approaches easier to use across biomedical research.
What is the overall purpose of this opportunity?
The purpose is to support development of novel, innovative tools and technologies that make it easier for the broader biomedical research community to study glycans (carbohydrates) and their functions. A key theme is reducing barriers so that researchers who are not glycoscience specialists can still incorporate glycan measurements and experiments into routine research.
What problem is NIH trying to solve with this program?
Glycans are important in health and disease, but they are often difficult to study because they are structurally complex and diverse, and they can be harder to measure, characterize, or manipulate than genes and proteins. This initiative aims to close that practical gap by enabling more accessible, affordable, and usable technologies.
What types of projects does the opportunity seek to fund?
The scientific emphasis is on tool and technology development that supports identification, tracking, manipulation, and functional analysis of glycans. The focus is on building practical capabilities rather than answering a single biological question.
What does "identification" of glycans refer to in this context?
Identification generally refers to detecting glycans and determining which glycans are present in a sample or system, including improvements in glycan detection and structural characterization approaches.
What does "tracking" glycans mean for proposed tools?
Tracking refers to methods that allow glycans to be followed in biological systems, including labeling and imaging approaches that help visualize or monitor glycan presence, location, or changes over time.
What does "manipulation" of glycans mean in this funding call?
Manipulation points to technologies that allow experimental perturbation or engineering of glycans, such as glycoengineering strategies or other methods to alter glycan structures or processing in order to study function.
What does "analysis of glycans and their functions" include?
It includes analytical platforms and methods that connect glycan changes to biological outcomes, enabling researchers to interpret how glycan structure or abundance relates to function in cells, tissues, immunity, cancer, pathogens, development, and other disease-relevant processes.
Are specific technology areas mentioned as priorities or examples?
Examples of relevant innovations include improvements in glycan detection, structural characterization, labeling and imaging, enrichment and separation methods, glycoengineering or perturbation strategies, and analytical platforms that link glycan changes to biological effects.
Is this opportunity intended for clinical trials?
The program is described as having broad translational impact, but not necessarily focused on clinical trials. The emphasis is on enabling tools that make glycan-related measurements and experiments more routine across many areas of biomedicine.
What does the U01 mechanism mean?
U01 is a cooperative agreement mechanism. It indicates NIH staff are expected to have substantial involvement compared with a typical investigator-initiated grant. This often aligns with milestone-driven progress, coordination, and harmonization with broader program goals.
Why use a cooperative agreement for glycoscience tool development?
The program aims to create enabling technologies intended for wide adoption, where coordination, dissemination, usability, and alignment with program objectives can be as important as the underlying invention. A U01 supports active partnership and coordination toward those goals.
What is the activity category for this funding opportunity?
The activity category is Health.
What CFDA number is associated with this opportunity?
The associated CFDA number is 93.310.
How much funding is available per award?
The posting lists an award ceiling of $400,000.
How many awards were anticipated?
The opportunity anticipated about three awards.
When was the opportunity posted, and what was the closing date?
The posting shows a creation date of September 16, 2016, with an original closing date of November 28, 2016.
What kinds of deliverables or outputs are expected?
Because the program emphasizes accessibility and affordability, successful projects would be expected to produce outputs the community can adopt, such as robust workflows, platforms, reagents, software, standards, or integrated methods that improve reproducibility and reduce the need for specialized expertise.
How does this opportunity define "accessibility" for glycoscience tools?
Accessibility is framed as lowering barriers for non-specialists by making tools easier to use, more affordable, and more practical for typical biomedical labs to adopt as part of routine research.
Who is eligible to apply?
Eligibility is broad and includes multiple government entities (state, county, city/township, special districts), independent school districts, public and private institutions of higher education, federally recognized tribal governments and other tribal organizations, public housing authorities/Indian housing authorities, nonprofits with or without 501(c)(3) status, for-profit organizations (other than small businesses), and small businesses, plus additional categories as clarified in the full announcement.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also listed as eligible.
Are academic institutions eligible?
Yes. Public and private institutions of higher education are included among eligible applicants.
Are tribal entities eligible?
Yes. Federally recognized tribal governments and other tribal organizations are listed as eligible applicants.
Are nonprofits eligible even if they do not have 501(c)(3) status?
Yes. Nonprofits with or without 501(c)(3) status are included among eligible applicants.
What kinds of disciplines or teams are a good fit for this program?
The opportunity is described as tool-building and interdisciplinary, where innovations may come from academic labs, research institutes, biotechnology or instrumentation companies, or hybrid collaborations combining engineering, chemistry, analytics, computation, and biology.
Is the goal to fund many small exploratory studies?
No. The description indicates a targeted, competitive call intended to seed a small set of projects with potential to produce broadly enabling glycoscience technologies.
What does "broad adoption" imply for proposed tools?
Broad adoption implies the outputs should be practical and usable by the wider biomedical research community, not just highly specialized glycobiology labs, and should support routine integration of glycan-related methods into diverse research areas.
What biomedical areas could benefit from these tools?
The description highlights applications across cells, tissues, pathogens, immunity, cancer, development, and other disease-relevant processes, reflecting the idea that glycans are deeply involved in many aspects of health and disease.
Does this opportunity focus only on measuring glycans?
No. The scope includes identifying glycans, tracking them, manipulating them experimentally, and analyzing their functions, which extends beyond measurement to include perturbation and linking glycan changes to biological outcomes.
What is the intended long-term impact of this program?
The intended payoff is to make glycan science easier, more affordable, and more routine, enabling faster and deeper insight into how carbohydrates contribute to health and disease by allowing many more researchers to include glycan studies in their work.
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