Opportunity Information: Apply for DE FOA 0001192
Apply for DE FOA 0001192
- The Office of Science in the science and technology and other research and development sector is offering a public funding opportunity titled "NOVEL IN SITU IMAGING AND MEASUREMENT TECHNOLOGIES FOR BIOLOGICAL SYSTEMS SCIENCE" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 81.049 Office of Science Financial Assistance Program.
- This funding opportunity was created on Sep 10, 2014 and posted on Sep 10, 2014.
- Applicants must submit their applications by Dec 18, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
- All types of applicants are eligible to apply except DOE/NNSA National Laboratories which are not eligible to apply for funding as a prime recipient (lead organization).
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Opportunity Summary:
The Department of Energy (DOE), Office of Science, Office of Biological and Environmental Research (BER) issued this Funding Opportunity Announcement (DE-FOA-0001192) to stimulate the development of new in situ imaging and measurement technologies for biological systems science, with a strong emphasis on bioenergy-relevant plants and microbes. The core idea is to move beyond static or destructive sampling and instead create tools that can watch biological processes as they happen, inside intact cells, tissues, and communities. BER is looking for technology development that enables researchers to study how information and materials move and are exchanged across membranes, among subcellular compartments, between individual microbial cells, and throughout multicellular systems such as microbial communities and plant tissues.
The FOA prioritizes approaches that are dynamic, nondestructive, and capable of functioning in situ, meaning measurements are taken in the native context rather than after extensive extraction, fixation, or disruption. The intended capabilities include multifunctional imaging and quantitative flux measurements, so that applicants are not only visualizing structures or locations but also quantifying rates and flows of key metabolites or biochemical activities over time. A central scientific motivation is to support integrative, multiscale analysis: connecting what happens at molecular and subcellular scales to emergent whole-cell and system-level behaviors. In practical terms, DOE is aiming for technologies that can help explain and eventually predict how spatial organization, physical connectivity, and chemical exchanges collectively drive metabolism and communication in complex biological systems.
A major expected outcome is the creation of imaging and measurement platforms that can do two things particularly well. First, they should be able to resolve multiple key metabolic processes over time, either within a single cell, across interacting cells, or within structured multicellular environments. Second, they should bridge a longstanding gap between molecular-scale information (for example, localized chemistry or compartment-specific activity) and systems-level understanding (how an entire cell, tissue, or community behaves and responds). The FOA frames this as enabling predictive understanding, meaning the technologies should support models or hypotheses that can forecast biological behavior based on observed spatial and temporal relationships and measured exchanges of chemicals and signals.
From an administrative standpoint, this is a discretionary grant program under the Office of Science Financial Assistance Program (CFDA 81.049), categorized as science and technology and other research and development. DOE anticipated making about five awards, with an estimated total program funding level of $5,000,000. No cost sharing or matching was required. The opportunity was posted on September 10, 2014, with an application deadline of December 18, 2014, and it was later archived on March 18, 2015. Eligibility was broadly open to essentially all applicant types, with one key restriction: DOE/NNSA National Laboratories were not eligible to apply as the prime (lead) recipient, although they could typically participate in other roles if allowed by the full announcement’s terms.
For applicants or institutions needing help accessing the full announcement, the FOA listed points of contact at DOE: Kimberlie J. Laing (Grants Specialist, kim.laing@science.doe.gov, 301-903-3026) and Prem C. Srivastava (Program Manager, prem.srivastava@science.doe.gov, 301-903-4071).
Funding Opportunity Announcement (DE-FOA-0001192) - FAQs
1) What is this funding opportunity?
This is a Department of Energy (DOE) Office of Science, Office of Biological and Environmental Research (BER) Funding Opportunity Announcement (FOA) focused on developing new in situ imaging and measurement technologies for biological systems science, with a strong emphasis on bioenergy-relevant plants and microbes.
2) What is the main purpose of the FOA?
The FOA aims to stimulate technology development that moves beyond static or destructive sampling and instead enables researchers to observe biological processes as they occur, inside intact cells, tissues, and communities.
3) What kinds of technologies is DOE/BER trying to develop through this FOA?
DOE/BER is looking for dynamic, nondestructive, in situ imaging and measurement tools that can monitor biological processes in their native context. The FOA emphasizes technologies that can provide multifunctional imaging and quantitative flux measurements over time.
4) What does "in situ" mean in the context of this FOA?
In situ means measurements are taken in the native biological context (for example, within intact cells, tissues, or communities) rather than after extensive extraction, fixation, or disruption.
5) Why does the FOA emphasize moving away from destructive sampling?
The FOA is centered on enabling observation of biological processes as they happen. Destructive or static approaches can disrupt the system and may miss time-dependent behavior, spatial organization, and exchanges of materials that occur in living, intact systems.
6) What biological systems are most emphasized?
The FOA places a strong emphasis on bioenergy-relevant plants and microbes, including systems such as microbial communities and plant tissues.
7) What biological processes or interactions are of interest?
The FOA highlights studying how information and materials move and are exchanged across membranes, among subcellular compartments, between individual microbial cells, and throughout multicellular systems such as microbial communities and plant tissues.
8) What types of measurements are especially encouraged?
The FOA prioritizes technologies that support multifunctional imaging and quantitative flux measurements. This means the tools should not only show structures or locations but also quantify rates and flows of key metabolites or biochemical activities over time.
9) What does "multifunctional imaging" imply here?
Based on the FOA description, multifunctional imaging refers to imaging approaches that can resolve multiple key metabolic processes over time, potentially within a single cell, across interacting cells, or within structured multicellular environments.
10) What is meant by "quantitative flux measurements" in this FOA?
Quantitative flux measurements refer to measuring rates and flows (fluxes) of metabolites, biochemical activities, or exchanges of chemicals and signals, and doing so over time rather than as a single static snapshot.
11) What scientific gap is this FOA trying to address?
The FOA aims to bridge the gap between molecular-scale information (such as localized chemistry or compartment-specific activity) and systems-level understanding (how an entire cell, tissue, or community behaves and responds).
12) What does DOE mean by "integrative, multiscale analysis"?
Integrative, multiscale analysis in this FOA refers to connecting events at molecular and subcellular scales to emergent whole-cell and system-level behaviors, so that spatial and temporal relationships can be linked to overall function.
13) What outcomes are expected from the funded projects?
The FOA describes an expected outcome of creating imaging and measurement platforms that (1) resolve multiple key metabolic processes over time in cells or multicellular environments and (2) connect molecular-scale observations to system-level behavior and understanding.
14) How does the FOA relate to predictive understanding of biology?
The FOA frames these technologies as enabling predictive understanding by supporting models or hypotheses that can forecast biological behavior based on observed spatial and temporal relationships and measured exchanges of chemicals and signals.
15) What program is this grant administered under?
This is a discretionary grant program under the DOE Office of Science Financial Assistance Program (CFDA 81.049), categorized as science and technology and other research and development.
16) How many awards did DOE anticipate making?
DOE anticipated making about five awards under this FOA.
17) What was the estimated total funding level for the program?
The FOA listed an estimated total program funding level of $5,000,000.
18) Was cost sharing or matching required?
No. The FOA stated that no cost sharing or matching was required.
19) When was the FOA posted?
The FOA was posted on September 10, 2014.
20) What was the application deadline?
The application deadline was December 18, 2014.
21) Is this opportunity still open?
No. The FOA was later archived on March 18, 2015.
22) Who was eligible to apply?
Eligibility was broadly open to essentially all applicant types, with one key restriction described in the FOA regarding DOE/NNSA National Laboratories.
23) Can DOE/NNSA National Laboratories apply as the lead recipient?
No. DOE/NNSA National Laboratories were not eligible to apply as the prime (lead) recipient under this FOA.
24) Could DOE/NNSA National Laboratories participate in any way?
The FOA indicated that DOE/NNSA National Laboratories could typically participate in other roles if allowed by the full announcement's terms, but they could not serve as the prime (lead) recipient.
25) Who can I contact at DOE for help with the full announcement?
The FOA listed two DOE contacts: Kimberlie J. Laing (Grants Specialist) at kim.laing@science.doe.gov or 301-903-3026, and Prem C. Srivastava (Program Manager) at prem.srivastava@science.doe.gov or 301-903-4071.
26) What DOE office issued this FOA?
The FOA was issued by the Department of Energy (DOE), Office of Science, Office of Biological and Environmental Research (BER).
27) What is the FOA number for this opportunity?
The FOA number is DE-FOA-0001192.
28) What is the central technical theme across the FOA?
The central theme is developing tools that can observe biological processes dynamically and nondestructively within intact biological systems, and that can quantify exchanges and fluxes to connect molecular-level activity with system-level behavior.
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