Opportunity Information: Apply for RFA HG 15 032
Apply for RFA HG 15 032
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Novel Nucleic Acid Sequencing Technology Development (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Aug 17, 2015 and posted on Aug 17, 2015.
- Applicants must submit their applications by Aug 27, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $700,000.00 in funding.
- Eligible applicants include: Small businesses Native American tribal governments (Federally recognized) For profit organizations other than small businesses Special district governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education State governments County governments City or township governments Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Novel Nucleic Acid Sequencing Technology Development (R01) opportunity (Funding Opportunity Number RFA-HG-15-032) is a National Institutes of Health (NIH) research grant announcement aimed at pushing sequencing beyond the current state of the art. The central goal is to fund development of genuinely new technologies that open up new approaches to DNA sequencing and, importantly, direct RNA sequencing (meaning sequencing RNA molecules without first converting them to cDNA). The announcement is deliberately geared toward innovation rather than incremental optimization, and it explicitly welcomes high-risk, high-payoff ideas where the potential impact is large even if the technical path is uncertain.
In terms of what NIH is looking to support, applicants can come in from a few angles. One path is proposing an entirely novel, end-to-end sequencing system, essentially a complete platform concept that could plausibly change what sequencing looks like in the future. Another path is to focus on key bottlenecks or underlying technical challenges that stand in the way of a new system component, such as chemistry, physics, sensing, sample handling, signal processing, basecalling, or other enabling subsystems, as long as the work is clearly tied to making new sequencing approaches feasible. A third path is to take an existing sequencing approach and make a major leap forward, with the FOA emphasizing improvements of at least an order of magnitude, meaning roughly a 10x improvement in a meaningful performance dimension (for example, accuracy, read length, throughput, cost per base, speed, required input amount, or ability to read difficult molecules or modifications). The emphasis on "methods other than those currently in use" signals that proposals are expected to look beyond well-worn strategies and explore fresh measurement principles, chemistries, or device concepts.
This is an R01 mechanism, so it is positioned for substantial, investigator-driven research projects that can support significant technology development work. The activity category is Health, and it is associated with CFDA 93.172 (Human Genome Research), reflecting the broader genomics mission area. The total estimated funding listed for the announcement is $1,500,000, with an award ceiling of $700,000, which sets an upper bound on the amount anticipated for an individual award under this FOA (the exact number of awards and final budgets would typically depend on application quality, program priorities, and available funds).
Eligibility is broad and covers many U.S.-based organization types across academia, government, nonprofit, and industry. Eligible applicants include public and state-controlled institutions of higher education as well as private institutions of higher education, nonprofits (including those with 501(c)(3) status and certain nonprofits without 501(c)(3) status), for-profit organizations including small businesses, and a variety of governmental entities (state governments, county governments, city or township governments, special district governments, independent school districts, and certain housing authorities). Tribal governments and tribal organizations are included, and the eligibility language also highlights categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and eligible federal agencies. A key restriction is that non-U.S. (foreign) organizations and non-U.S. components of U.S. organizations are not eligible to apply as the applicant organization; however, "foreign components" (as NIH defines them in policy) are allowed, meaning collaborations or project elements involving foreign work may be permissible under NIH rules when properly justified and structured.
Administratively, this was a discretionary grant opportunity posted and created on August 17, 2015, with an original and current closing date of August 27, 2017, and an archive date of September 27, 2017, meaning it is no longer an active solicitation in its listed form. The announcement directs applicants to the full FOA text hosted by NIH for complete requirements and instructions (http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-15-032.html). For access or linking issues, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, the opportunity is best understood as NIH putting a clear stake in the ground for transformative sequencing advances: either invent a new sequencing paradigm, solve the hardest enabling technical barriers for new system components, or deliver a step-change improvement (around 10x) that would materially shift what sequencing can do, with special encouragement for creative ideas and ambitious, unconventional approaches, including those that may look risky by traditional standards but could pay off in major capability gains.
Frequently Asked Questions (FAQs): Novel Nucleic Acid Sequencing Technology Development (R01) - RFA-HG-15-032
What is the name of this grant opportunity?
The opportunity is titled Novel Nucleic Acid Sequencing Technology Development (R01).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-HG-15-032.
Who is offering this opportunity?
This is a National Institutes of Health (NIH) research grant announcement.
What is the main purpose of this FOA?
The central goal is to fund development of genuinely new sequencing technologies that push beyond the current state of the art, including new approaches to DNA sequencing and, importantly, direct RNA sequencing (sequencing RNA molecules without first converting them to cDNA).
Does this FOA prioritize innovation or incremental improvements?
It is deliberately geared toward innovation rather than incremental optimization. It explicitly welcomes high-risk, high-payoff ideas where the potential impact is large even if the technical path is uncertain.
What types of projects are encouraged under this FOA?
The FOA supports multiple innovation paths, including:
- Entirely novel, end-to-end sequencing systems (a complete platform concept).
- Solving key bottlenecks or enabling technical challenges tied to new sequencing components (for example, chemistry, physics, sensing, sample handling, signal processing, or basecalling).
- Major leaps forward applied to an existing sequencing approach, where the work delivers a step-change improvement.
What does the FOA mean by a "major leap forward"?
The FOA emphasizes improvements of at least an order of magnitude, meaning roughly a 10x improvement in a meaningful performance dimension.
What performance dimensions are examples of meaningful 10x improvements?
Examples listed include accuracy, read length, throughput, cost per base, speed, required input amount, and the ability to read difficult molecules or modifications.
Is direct RNA sequencing specifically called out?
Yes. The FOA highlights the importance of direct RNA sequencing, meaning sequencing RNA molecules without first converting them to cDNA.
Does the FOA expect approaches beyond existing common methods?
Yes. The FOA signals that proposals are expected to explore methods other than those currently in use, including fresh measurement principles, chemistries, or device concepts.
What grant mechanism is used for this opportunity?
This opportunity uses the R01 mechanism, positioned for substantial, investigator-driven research projects supporting significant technology development.
What is the activity category associated with the opportunity?
The activity category is Health.
What CFDA number is associated with this announcement?
The announcement is associated with CFDA 93.172 (Human Genome Research).
How much total funding is estimated for this FOA?
The total estimated funding listed for the announcement is $1,500,000.
What is the award ceiling for an individual award?
The award ceiling listed is $700,000, which sets an upper bound on the amount anticipated for an individual award under this FOA.
Is the number of awards guaranteed?
No specific number of awards is stated here. The final number of awards and budgets would typically depend on application quality, program priorities, and available funds.
Which organization types are eligible to apply?
Eligibility is broad and includes many U.S.-based organizations across academia, government, nonprofit, and industry, including:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofits (including those with 501(c)(3) status and certain nonprofits without 501(c)(3) status)
- For-profit organizations, including small businesses
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Certain housing authorities
- Tribal governments and tribal organizations
- Eligible federal agencies
- Faith-based or community-based organizations
Are minority-serving institutions specifically mentioned as eligible?
Yes. The eligibility language highlights categories such as HBCUs, Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Can a non-U.S. (foreign) organization apply as the applicant?
No. Non-U.S. (foreign) organizations are not eligible to apply as the applicant organization under this FOA.
Can a non-U.S. component of a U.S. organization apply as the applicant?
No. Non-U.S. components of U.S. organizations are not eligible to apply as the applicant organization.
Are foreign collaborations allowed at all?
Yes. The FOA notes that "foreign components" (as NIH defines them in policy) are allowed, meaning collaborations or project elements involving foreign work may be permissible under NIH rules when properly justified and structured.
When was this opportunity created and posted?
It was created and posted on August 17, 2015.
What was the closing date for this FOA?
The original and current closing date listed is August 27, 2017.
Is this funding opportunity still open?
No. It has an archive date of September 27, 2017, indicating it is no longer an active solicitation in its listed form.
Where can applicants find the full FOA text and official instructions?
The FOA text is hosted by NIH at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-15-032.html
Who should be contacted for access or linking issues with the FOA webpage?
The contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
How should a potential applicant interpret the overall intent of this FOA?
Overall, it reflects NIH prioritizing transformative sequencing advances: inventing a new sequencing paradigm, solving major enabling technical barriers, or delivering a step-change improvement (around 10x) that materially shifts what sequencing can do, with special encouragement for ambitious and unconventional approaches.
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