Opportunity Information: Apply for RFA DE 16 007
Apply for RFA DE 16 007
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Novel or Enhanced Dental Restorative Materials for Class V Lesions (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Jun 11, 2015 and posted on Jun 11, 2015.
- Applicants must submit their applications by Sep 29, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: Small businesses City or township governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities For profit organizations other than small businesses Public and State controlled institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Private institutions of higher education Independent school districts State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity titled "Novel or Enhanced Dental Restorative Materials for Class V Lesions (R01)" (Funding Opportunity Number RFA-DE-16-007) is a National Institutes of Health (NIH) discretionary research grant designed to push the field of dental materials beyond the current standard options used to restore Class V lesions. Class V restorations are placed in the gingival third of the tooth, near the gumline, a location that tends to be clinically challenging because it combines difficult access and moisture control issues with a demanding biological and mechanical environment. The main goal of the announcement is to stimulate research that results in new or improved restorative materials that clearly outperform existing materials in real-world clinical service life, meaning they last longer and function better once placed in patients.
A central theme of the announcement is that Class V lesions create a unique set of material requirements that are not fully met by common restorative choices. Restorations in this region must tolerate repeated mechanical stresses from tooth flexure and chewing, withstand chemical challenges from the oral environment, and maintain stable bonding to tooth structures that can be harder to seal reliably near the gumline. The gumline area also makes dental treatment more complicated due to visibility and isolation problems, as well as higher risk of contamination during placement. Because of these constraints, failure modes such as marginal leakage, debonding, wear, secondary caries, postoperative sensitivity, and aesthetic degradation can occur more readily than in other tooth locations. The FOA is essentially a call for fundamental improvements that address these persistent clinical shortcomings, rather than small incremental tweaks that do not translate into meaningfully longer-lasting restorations.
The funding mechanism is an R01 grant, which typically supports hypothesis-driven, multi-year research projects that can include basic, translational, and applied research components. The FOA is categorized under health research activities and is linked to CFDA number 93.121, Oral Diseases and Disorders Research. The opportunity does not require cost sharing or matching, which lowers barriers for applicants who may not have institutional funds to supplement the project budget.
In terms of funding scope, the announcement listed an estimated total funding amount of $2,000,000 and an award ceiling of $250,000. That ceiling indicates the maximum amount expected per award under the terms of the FOA, and it signals that NIH was looking for well-scoped projects focused on targeted advances in Class V restorative material performance rather than very large, resource-intensive programs. The FOA was posted on June 11, 2015, with an original and final application closing date of September 29, 2015, and it was archived on October 30, 2015, meaning it was a time-limited call rather than an open-ended standing program announcement.
Eligibility was broad and inclusive, reflecting NIH's typical approach to encouraging participation across academic, nonprofit, governmental, and private-sector research communities. Eligible applicants included small businesses, for-profit organizations (including those other than small businesses), nonprofits with or without 501(c)(3) status, public and private institutions of higher education, and a range of governmental entities (city or township, county, special district, state governments, and independent school districts). The eligibility list also explicitly encompassed tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and a wide set of institution types and community-based entities such as faith-based or community-based organizations. The announcement further clarified that additional eligible applicants included minority-serving institutions (for example, HBCUs, Hispanic-serving institutions, AANAPISI institutions, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities), eligible federal agencies, U.S. territories or possessions, and even non-U.S. entities (foreign organizations) and regional organizations. This breadth suggests the FOA aimed to attract both traditional academic dental materials researchers and innovators from industry or interdisciplinary engineering and biomaterials groups capable of delivering practical, clinic-relevant advances.
Overall, the opportunity can be summarized as a focused NIH call to develop restorative materials specifically optimized for the gumline region, with the key success criterion being demonstrably improved clinical longevity compared with current options. The FOA emphasizes the complexity of the Class V environment and highlights the need for improvements that translate into real performance gains in patients, not just better laboratory metrics. For applicants, it signaled a clear expectation: propose research that meaningfully changes how Class V lesions can be restored, by addressing the underlying reasons restorations in this region fail and by delivering materials that are more reliable under the difficult conditions near the gingiva.
The full announcement was made available through an NIH link (http://grants.nih.gov/grants/guide/rfa-files/RFA-DE-16-007.html). For access or technical issues, the NIH Office of Extramural Research (OER) webmaster contact was provided (FBOWebmaster@OD.NIH.GOV).
FAQs: Novel or Enhanced Dental Restorative Materials for Class V Lesions (R01) (RFA-DE-16-007)
What is the title of this grant opportunity?
The opportunity is titled "Novel or Enhanced Dental Restorative Materials for Class V Lesions (R01)."
What is the funding opportunity number?
The Funding Opportunity Number is RFA-DE-16-007.
Which agency is offering this grant?
This is a National Institutes of Health (NIH) discretionary research grant opportunity.
What type of grant mechanism is being used?
The funding mechanism is an R01, which typically supports hypothesis-driven, multi-year research projects that may include basic, translational, and applied research components.
What is the main purpose of this FOA?
The FOA is intended to stimulate research that leads to new or improved restorative materials for Class V lesions that clearly outperform existing materials in real-world clinical service life (lasting longer and functioning better in patients).
What are Class V lesions and why are they important in this FOA?
Class V restorations are placed in the gingival third of the tooth near the gumline. This location is clinically challenging because it combines difficult access and moisture control issues with a demanding biological and mechanical environment.
Why does the FOA emphasize the gumline (gingival) region?
The gumline area can be harder to treat due to visibility and isolation problems and a higher risk of contamination during placement. The materials must also maintain stable bonding near the gingiva, where sealing can be less reliable.
What makes Class V restorations more likely to fail compared with restorations in other locations?
The FOA highlights that the Class V environment can lead to failure modes such as marginal leakage, debonding, wear, secondary caries, postoperative sensitivity, and aesthetic degradation occurring more readily than in other tooth locations.
What kinds of stresses and challenges must proposed materials address?
Materials are expected to tolerate repeated mechanical stresses from tooth flexure and chewing, withstand chemical challenges from the oral environment, and maintain stable bonding to tooth structures in a region that is difficult to isolate and keep dry.
Does the FOA want incremental improvements or major performance gains?
The FOA is framed as a call for fundamental improvements that address persistent clinical shortcomings, rather than small incremental tweaks that do not translate into meaningfully longer-lasting restorations.
How does the FOA define success for proposed restorative materials?
A key success criterion is demonstrably improved clinical longevity compared with current options, with improvements that translate into real performance gains in patients (not just improved laboratory metrics).
What is the CFDA number associated with this opportunity?
The opportunity is linked to CFDA number 93.121, Oral Diseases and Disorders Research.
What is the estimated total funding amount listed in the announcement?
The announcement listed an estimated total funding amount of $2,000,000.
What is the award ceiling for this FOA?
The award ceiling is $250,000, indicating the maximum amount expected per award under the FOA.
What does the award ceiling suggest about the expected project scope?
The ceiling suggests NIH was looking for well-scoped projects focused on targeted advances in Class V restorative material performance rather than very large, resource-intensive programs.
Is cost sharing or matching required?
No. The opportunity does not require cost sharing or matching.
When was the FOA posted?
The FOA was posted on June 11, 2015.
What were the application due dates?
The original and final application closing date was September 29, 2015.
Is this opportunity still open?
No. The FOA was archived on October 30, 2015, indicating it was a time-limited call rather than an open-ended, standing program announcement.
Who was eligible to apply?
Eligibility was broad and included small businesses, for-profit organizations (including those other than small businesses), nonprofits with or without 501(c)(3) status, public and private institutions of higher education, and a range of governmental entities.
What types of government entities were listed as eligible?
Eligible governmental entities included city or township governments, county governments, special district governments, state governments, and independent school districts.
Were tribal entities eligible?
Yes. The eligibility list explicitly included tribal governments and tribal organizations.
Were public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities were included in the eligibility list.
Were faith-based or community-based organizations eligible?
Yes. The eligibility list encompassed a wide set of institution types and community-based entities, including faith-based or community-based organizations.
Were minority-serving institutions eligible?
Yes. The announcement explicitly included minority-serving institutions such as HBCUs, Hispanic-serving institutions, AANAPISI institutions, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities.
Could federal agencies apply?
Yes. The eligibility list included eligible federal agencies.
Were U.S. territories or possessions eligible?
Yes. U.S. territories or possessions were included in the eligibility list.
Could non-U.S. organizations apply?
Yes. The eligibility list included non-U.S. entities (foreign organizations) and regional organizations.
Where can applicants find the full FOA text?
The full announcement was made available through NIH at http://grants.nih.gov/grants/guide/rfa-files/RFA-DE-16-007.html.
Who should be contacted for access or technical issues related to the FOA link?
For access or technical issues, the NIH Office of Extramural Research (OER) webmaster contact provided was FBOWebmaster@OD.NIH.GOV.
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