Opportunity Information: Apply for RFA HD 15 031

  • The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Novel Tools to Assess Human Placental Structure and Function (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Dec 15, 2014 and posted on Dec 15, 2014.
  • Applicants must submit their applications by Feb 19, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $500,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: Independent school districts Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments For profit organizations other than small businesses Private institutions of higher education State governments Special district governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The Novel Tools to Assess Human Placental Structure and Function (R21) opportunity (Funding Opportunity Number RFA-HD-15-031) was a National Institutes of Health (NIH) funding announcement focused on advancing how the human placenta can be evaluated during pregnancy. The central goal was to spur research that develops safe, real-time methods to measure placental development and function in vivo across gestation, with a clear emphasis on approaches that are non-invasive or at least minimally invasive. In practical terms, the FOA targeted new tools and techniques that could help clinicians and researchers monitor placental health while pregnancy is ongoing, rather than relying mainly on indirect indicators or information available only at delivery. The overall theme is improving the ability to understand, detect, and track placental changes that influence fetal growth and pregnancy outcomes.

This was an R21 mechanism, meaning it was intended to support early-stage, exploratory, and potentially high-impact projects that may still be in the development or proof-of-concept phase. The funding instrument type was a grant under the broad activity area of health, and it fell under CFDA 93.865 (Child Health and Human Development Extramural Research), which aligns with NIH investments in maternal-fetal health and child development. There was no cost-sharing or matching requirement, reducing barriers for applicants by not requiring institutional co-investment as a condition of award.

In terms of funding size and constraints, the announcement listed an estimated total funding amount of $500,000 and an award ceiling of $200,000. That structure signals that NIH expected to make a limited number of relatively modest awards, consistent with R21 projects that aim to generate foundational data, demonstrate feasibility, or develop prototypes that could later be expanded through larger grants. Applicants would typically use this kind of support to build and validate a new measurement approach, establish preliminary performance metrics, or show that a technique can be applied safely and effectively in pregnant participants.

Eligibility was broad and included a wide range of domestic and non-domestic organizations. Eligible applicants spanned public and private institutions of higher education, state and local governments, independent school districts, special district governments, small businesses, for-profit entities (including those other than small businesses), and nonprofit organizations both with and without 501(c)(3) status. The FOA also explicitly included tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and an extensive list of institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Faith-based and community-based organizations, regional organizations, U.S. territories or possessions, eligible federal agencies, and foreign organizations were also identified as eligible, indicating NIH interest in drawing innovation from many sectors and geographies.

Administratively, the opportunity was posted and created on December 15, 2014, with an original and current closing date of February 19, 2015, and an archive date of March 22, 2015, meaning it is no longer open for applications. The additional information link pointed to the NIH Grants Guide listing for the FOA, and support contacts were provided through the NIH Office of Extramural Research (OER) for technical issues accessing or linking to the announcement.

Overall, this FOA can be summarized as a targeted NIH effort to accelerate novel, safe, real-time assessment technologies for placental structure and function throughout pregnancy, using an exploratory grant mechanism and making the competition accessible to a very broad applicant pool, including academic, nonprofit, government, commercial, tribal, and international organizations.

FAQs: Novel Tools to Assess Human Placental Structure and Function (R21) - RFA-HD-15-031

What is this funding opportunity?

This is an NIH funding announcement titled "Novel Tools to Assess Human Placental Structure and Function (R21)" under Funding Opportunity Number (FON) RFA-HD-15-031. It focused on improving how the human placenta can be evaluated during pregnancy.

What was the main goal of RFA-HD-15-031?

The central goal was to spur research developing safe, real-time methods to measure placental development and function in vivo across gestation. The emphasis was on approaches that are non-invasive or minimally invasive.

What kinds of methods or approaches did the FOA emphasize?

The FOA emphasized tools and techniques that could assess placental structure and function during an ongoing pregnancy, ideally in real time, and preferably using non-invasive or minimally invasive approaches.

Why was real-time, in vivo placental assessment important in this FOA?

The intent was to improve the ability to monitor placental health while pregnancy is ongoing, rather than relying mainly on indirect indicators or information only available at delivery. This supports better understanding, detection, and tracking of placental changes that can influence fetal growth and pregnancy outcomes.

What type of award mechanism was used?

This opportunity used the NIH R21 mechanism, which is intended for early-stage, exploratory, and potentially high-impact projects that may still be in development or proof-of-concept.

What does it mean that this was an R21 opportunity?

As described in the announcement, the R21 mechanism is meant to support exploratory work, feasibility testing, early validation, or prototype development. It is commonly used to generate foundational data that could support later, larger-scale research projects.

What was the activity area or general field for this grant?

The funding instrument type was a grant in the broad activity area of health, aligned with NIH interests in maternal-fetal health and child development.

What CFDA number was associated with this opportunity?

This FOA fell under CFDA 93.865, described as Child Health and Human Development Extramural Research.

How much total funding was estimated for this announcement?

The announcement listed an estimated total funding amount of $500,000.

Was there an award ceiling (maximum award amount)?

Yes. The announcement listed an award ceiling of $200,000.

What does the $500,000 total and $200,000 ceiling suggest about the size and number of awards?

It suggests NIH expected to make a limited number of relatively modest awards, consistent with the R21 mechanism and its focus on exploratory or proof-of-concept research.

Was cost sharing or matching required?

No. The opportunity stated there was no cost-sharing or matching requirement.

Who was eligible to apply?

Eligibility was broad. The FOA included a wide range of domestic and non-domestic organizations across academia, government, nonprofit, and commercial sectors.

Were universities and colleges eligible?

Yes. Eligible applicants included public and private institutions of higher education, and the FOA also explicitly listed multiple institution categories such as HBCUs, Hispanic-serving Institutions, TCCUs, Alaska Native and Native Hawaiian Serving Institutions, and AANAPISIs.

Were state, local, or other government entities eligible?

Yes. Eligible applicants included state governments, local governments, independent school districts, special district governments, tribal governments, and public housing authorities/Indian housing authorities.

Were nonprofit organizations eligible?

Yes. The FOA included nonprofit organizations both with and without 501(c)(3) status.

Were for-profit organizations eligible?

Yes. Eligibility included small businesses, for-profit organizations (including those other than small businesses), and other commercial entities.

Were tribal organizations specifically included?

Yes. The FOA explicitly included tribal governments and tribal organizations as eligible applicants.

Were faith-based or community-based organizations eligible?

Yes. The FOA identified faith-based and community-based organizations as eligible.

Were U.S. territories or possessions eligible?

Yes. The FOA included U.S. territories or possessions among eligible applicants.

Could federal agencies apply?

Yes. Eligible federal agencies were listed among eligible applicants.

Were foreign (non-U.S.) organizations eligible?

Yes. The FOA indicated that foreign organizations were eligible.

Is this funding opportunity still open?

No. The FOA is no longer open for applications. It had a closing date of February 19, 2015, and an archive date of March 22, 2015.

When was this opportunity posted?

The opportunity was posted and created on December 15, 2014.

What were the application deadline and archive date?

The original and current closing date were February 19, 2015. The archive date was March 22, 2015.

Where could applicants find the official announcement details?

The additional information link pointed to the NIH Grants Guide listing for the FOA.

Who was listed as a support contact for technical issues?

Support contacts were provided through the NIH Office of Extramural Research (OER) for technical issues accessing or linking to the announcement.

What is a plain-language summary of what this FOA was trying to fund?

It was a targeted NIH effort to accelerate new, safe ways to evaluate placental structure and function throughout pregnancy in real time, using an exploratory R21 grant mechanism and allowing a very broad range of organizations to apply.

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