Opportunity Information: Apply for RFA DK 11 017
Apply for RFA DK 11 017
- The National Institutes of Health in the food and nutrition health income security and social services sector is offering a public funding opportunity titled "Nuclear Receptor Signaling Atlas (NURSA) Hub (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Oct 21, 2011 and posted on Oct 21, 2011.
- Applicants must submit their applications by Mar 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,800,000.00 to eligible and selected applicants.
- Eligible applicants include: Special district governments County governments Small businesses Private institutions of higher education For profit organizations other than small businesses State governments Independent school districts Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The NIH funding opportunity RFA-DK-11-017, titled "Nuclear Receptor Signaling Atlas (NURSA) Hub (U24)," supports the creation and operation of a central, collaborative "Hub" for the Nuclear Receptor Signaling Atlas program. The main aim is translational in the broad sense: to push discoveries in basic nuclear receptor biology toward practical relevance for human diseases and conditions where nuclear receptors play major roles. Nuclear receptors are a large family of transcription factors that respond to hormones, dietary lipids, and other ligands, shaping gene expression programs that influence metabolism, development, inflammation, reproduction, and many other physiological systems. Because nuclear receptor pathways are deeply connected to metabolic disease and other disorders, the program is positioned to make basic datasets more accessible and usable for investigators who are trying to connect molecular mechanisms to disease biology.
At the center of the program is the Hub, funded as a U24 cooperative agreement, meaning NIH intends substantial involvement in coordination and stewardship rather than simply issuing a standard research grant. The Hub is expected to provide the integration and cohesion needed to pull together data coming from multiple collaborative research projects, then aggregate, annotate, and present those data in a way that is modern, searchable, and genuinely user-friendly. In practice, the deliverable is a public-facing web portal, identified as www.nursa.org, which functions as the program's central access point for curated information and state-of-the-art datasets relevant to nuclear receptor signaling. The emphasis on annotation and presentation signals that this is not just about storing files; it is about adding context, standardizing metadata, and making results discoverable and interpretable across projects and disciplines.
A major programmatic goal is to help generate new concepts and validated datasets that can serve as a foundation for future research, especially research aimed at understanding nuclear receptors in human physiology and metabolic disease. By acting as a central informatics and coordination resource, the Hub is meant to accelerate the field by reducing fragmentation, making datasets comparable, and lowering the barrier for non-specialists to use nuclear receptor-related data. The overall vision is that a well-run hub and portal can help convert disconnected findings into a more coherent map of nuclear receptor actions across tissues, conditions, and disease states, thereby speeding hypothesis generation and improving reproducibility and reuse of data.
This opportunity is listed as discretionary funding and uses the cooperative agreement mechanism. It is associated with NIH and includes CFDA numbers 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research) and 93.865 (Child Health and Human Development Extramural Research), reflecting the cross-cutting relevance of nuclear receptor signaling across metabolic and developmental biology. The announcement was posted and created on October 21, 2011, with an original and current closing date of March 7, 2012, and an archive date of April 7, 2012. The estimated total funding is $1,800,000, and there is no cost sharing or matching requirement.
Eligibility is broad across U.S.-based organizations and includes state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits (including both 501(c)(3) and certain non-501(c)(3) categories); public housing authorities/Indian housing authorities; small businesses and other for-profit organizations; and federally recognized tribal governments as well as other tribal organizations. The eligibility language also highlights additional categories such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, U.S. territories or possessions, regional organizations, and faith-based or community-based organizations, along with eligible federal agencies. At the same time, the FOA clearly excludes non-U.S. entities: foreign institutions are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed.
For applicants, the core idea is that the funded group would function less like a single-lab research project and more like a community-facing infrastructure and coordination center. Success would depend on strong collaborative practices, technical capacity to manage and curate complex biological datasets, and a clear strategy for keeping the portal current, credible, and easy for researchers to navigate. The full announcement and detailed requirements were provided through NIH at the link: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-11-017.html. For technical issues accessing the posting, NIH listed the Office of Extramural Research webmaster contact at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is RFA-DK-11-017?
RFA-DK-11-017 is an NIH funding opportunity titled "Nuclear Receptor Signaling Atlas (NURSA) Hub (U24)." It supports the creation and operation of a central, collaborative "Hub" for the Nuclear Receptor Signaling Atlas (NURSA) program.
What is the overall purpose of the NURSA Hub?
The Hub is intended to serve as the program's central informatics and coordination resource, bringing cohesion to data generated by multiple collaborative research projects. A key goal is to make nuclear receptor signaling datasets easier to access, understand, compare, and reuse across the research community.
What does NIH mean by "translational" in this opportunity?
The opportunity frames "translational" broadly: it aims to help move discoveries from basic nuclear receptor biology toward practical relevance for human diseases and conditions where nuclear receptors play major roles, including metabolic disease and other disorders.
What are nuclear receptors, as described in the announcement?
Nuclear receptors are described as a large family of transcription factors that respond to hormones, dietary lipids, and other ligands. They shape gene expression programs that influence metabolism, development, inflammation, reproduction, and many other physiological systems.
Why does NIH emphasize nuclear receptor signaling in relation to disease?
The program is positioned around the idea that nuclear receptor pathways are deeply connected to metabolic disease and other disorders. By improving how basic datasets are presented and shared, the Hub is meant to support investigators connecting molecular mechanisms to disease biology.
What is the funding mechanism for this opportunity?
This opportunity uses a U24 cooperative agreement mechanism. That means NIH expects substantial involvement in coordination and stewardship, rather than treating it as a standard research grant with minimal ongoing NIH participation.
What is the NURSA Hub expected to produce or deliver?
A central deliverable is a public-facing web portal identified as www.nursa.org, designed to be the program's central access point for curated information and state-of-the-art datasets relevant to nuclear receptor signaling.
Is the Hub just a data repository?
No. The announcement emphasizes that the Hub is not simply about storing files. It is expected to aggregate, annotate, and present data in a modern, searchable, genuinely user-friendly way, including adding context and standardizing metadata so results are discoverable and interpretable.
What types of activities are implied for the Hub's role?
Based on the description, expected activities include integrating data from multiple collaborative projects, aggregating and curating those data, annotating datasets with useful context, standardizing metadata, and presenting information through an accessible and searchable web portal.
How is the Hub supposed to help the research community?
The Hub is intended to reduce fragmentation in the field, make datasets more comparable across projects, lower barriers for non-specialists to use nuclear receptor-related data, and speed hypothesis generation while improving reproducibility and reuse of data.
What is the long-term vision for the program?
The overall vision is that a well-run hub and portal can help convert disconnected findings into a more coherent map of nuclear receptor actions across tissues, conditions, and disease states, accelerating the field and supporting future research foundations.
Is this opportunity considered discretionary funding?
Yes. The opportunity is listed as discretionary funding and uses the cooperative agreement mechanism.
Which NIH-related program areas are associated with this opportunity (CFDA numbers)?
The announcement lists CFDA numbers 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research) and 93.865 (Child Health and Human Development Extramural Research), reflecting the cross-cutting relevance of nuclear receptor signaling.
What is the estimated total funding amount?
The estimated total funding for this opportunity is $1,800,000.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
When was the announcement posted, and what were the closing and archive dates?
The announcement was created and posted on October 21, 2011. The original and current closing date is March 7, 2012, and the archive date is April 7, 2012.
Who is eligible to apply?
Eligibility is broad for U.S.-based organizations and includes various government entities (state, county, city or township), special district governments, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) categories), public housing authorities/Indian housing authorities, small businesses and other for-profit organizations, federally recognized tribal governments, and other tribal organizations. The eligibility language also highlights categories such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities, Tribally Controlled Colleges and Universities, U.S. territories or possessions, regional organizations, faith-based or community-based organizations, and eligible federal agencies.
Are foreign institutions or non-U.S. components allowed to apply?
No. The FOA explicitly excludes non-U.S. entities: foreign institutions are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed.
What kind of applicant is NIH looking for, based on the description?
The announcement suggests the funded group should function less like a single-lab research project and more like a community-facing infrastructure and coordination center. Success is tied to collaborative practices, technical capacity to manage and curate complex biological datasets, and a strategy to keep the portal current, credible, and easy to navigate.
Where can applicants find the full funding announcement?
The full announcement is available through NIH at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-11-017.html
Who should be contacted for technical issues accessing the posting?
For technical issues accessing the posting, NIH listed the Office of Extramural Research webmaster contact: FBOWebmaster@OD.NIH.GOV
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