Opportunity Information: Apply for RFA RM 14 007
Apply for RFA RM 14 007
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Nucleomics Tools (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Sep 24, 2014 and posted on Sep 24, 2014.
- Applicants must submit their applications by Feb 2, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Small businesses For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments State governments Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Nucleomics Tools (U01) funding opportunity (RFA-RM-14-007) was a National Institutes of Health (NIH) cooperative agreement program designed to push beyond the limits of existing genome architecture methods by supporting the creation and validation of genuinely new ways to measure how the genome is organized in three dimensions and how that organization changes over time. The core goal was not simply to apply standard chromosome conformation or imaging workflows, but to develop physical, chemical, and biochemical approaches that can capture properties and dynamics of 3D genome organization that were not being measured well (or at all) with the tools available at the time. In practical terms, this FOA was aimed at enabling next-generation “nucleomics” capabilities, meaning toolsets that could reveal aspects of nuclear and chromatin structure, spatial relationships, and dynamic rearrangements with improved resolution, accuracy, throughput, or interpretability compared with prevailing methodologies.
This opportunity was posted on September 24, 2014, by NIH under CFDA 93.310 (Trans-NIH Research Support), and it used the cooperative agreement funding mechanism (U01). A U01 indicates that NIH expected substantial programmatic involvement during the award period, often including active coordination with NIH staff, milestone-driven progress, and alignment with broader program goals. The application closing date was February 2, 2015, and the opportunity was later archived on March 5, 2015. The FOA listed an estimated total funding amount of $3,000,000, with no cost-sharing or matching requirement, meaning applicants were not required to contribute non-federal matching funds as a condition of the award.
Eligibility was deliberately broad, reflecting the tool-development emphasis and the reality that breakthrough measurement technologies often come from multidisciplinary teams and diverse organization types. Eligible applicants included public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) organizations), small businesses, for-profit entities (including those other than small businesses), and many levels of government (state, county, city/township, special district governments, and public housing authorities/Indian housing authorities). The FOA also permitted applications from tribal governments (both federally recognized and other than federally recognized) and independent school districts. In addition, NIH explicitly allowed non-U.S. entities and foreign institutions to apply, as well as foreign components of U.S. organizations, consistent with NIH policy; this feature signaled an intent to draw on global expertise in chemistry, physics, microscopy, sequencing technologies, computational modeling, and related areas. The eligibility section also highlighted inclusion of organizations such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISIs, along with faith-based and community-based organizations and eligible federal agencies, underscoring an inclusive stance toward the research and development community.
Scientifically, the FOA centered on developing and validating measurement approaches rather than only generating biological findings. “Develop and validate” implies that proposed technologies were expected to move past concept-stage ideas and demonstrate credible performance, such as reproducibility, sensitivity, specificity, resolution, quantitative accuracy, scalability, and suitability for real biological samples. Because the focus was on properties and dynamics of genome organization, the program implicitly encompassed tools capable of capturing spatial genome features (for example, distances or contacts among loci, higher-order folding patterns, compartmentalization, or nuclear positioning) and temporal behaviors (for example, reorganization across time, cellular states, perturbations, or the cell cycle). The explicit call for physical, chemical, and biochemical approaches indicates NIH interest in a wide range of innovation spaces, including but not limited to new labeling chemistries, improved crosslinking or proximity-capture strategies, novel molecular recording schemes, advances in microscopy or nanoscale measurement, and hybrid workflows that integrate orthogonal measurement modalities to overcome limitations of any single method.
Administrative details provided with the announcement included a link to the full FOA text on the NIH grants site (http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-14-007.html). For access or linking problems, the contact listed was the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV), reflecting that the notice itself was distributed through NIH’s standard electronic posting and grants communication channels.
Frequently Asked Questions (FAQs)
What is the Nucleomics Tools (U01) funding opportunity (RFA-RM-14-007)?
RFA-RM-14-007, titled "Nucleomics Tools (U01)," was a National Institutes of Health (NIH) cooperative agreement program created to drive the development and validation of genuinely new technologies for measuring how the genome is organized in three dimensions (3D) and how that 3D organization changes over time.
What was the main purpose of this FOA?
The core purpose was to push beyond the limits of existing genome architecture methods by supporting tool development, especially approaches that could capture properties and dynamics of 3D genome organization that were not being measured well (or at all) using tools available at the time.
Was this opportunity focused on applying existing 3D genome methods or creating new ones?
It was focused on creating and validating new measurement approaches, not simply applying standard chromosome conformation capture methods or conventional imaging workflows.
What kinds of innovations did NIH seek under this program?
The FOA emphasized physical, chemical, and biochemical approaches designed to reveal nuclear and chromatin structure, spatial relationships, and dynamic rearrangements with improved resolution, accuracy, throughput, or interpretability compared with prevailing methodologies.
What does "nucleomics" mean in the context of this FOA?
In this FOA, "nucleomics" referred to next-generation toolsets intended to reveal aspects of nuclear and chromatin structure, spatial relationships among genomic loci, and dynamic rearrangements over time.
What NIH funding mechanism was used?
This opportunity used the U01 cooperative agreement mechanism.
What does a U01 cooperative agreement imply about NIH involvement?
A U01 indicates NIH expected substantial programmatic involvement during the award period. That commonly includes active coordination with NIH staff, milestone-driven progress, and alignment with broader program goals.
When was this FOA posted?
The opportunity was posted on September 24, 2014.
What was the application closing date?
The application closing date was February 2, 2015.
When was the FOA archived?
The opportunity was later archived on March 5, 2015.
Which NIH/CFDA program was associated with this announcement?
The announcement was listed under CFDA 93.310, described as Trans-NIH Research Support.
How much total funding was estimated for this FOA?
The FOA listed an estimated total funding amount of $3,000,000.
Was cost-sharing or matching required?
No. The FOA stated there was no cost-sharing or matching requirement, meaning applicants were not required to contribute non-federal matching funds as a condition of the award.
Who was eligible to apply?
Eligibility was broad. Eligible applicants included public and private institutions of higher education; nonprofits (both 501(c)(3) and non-501(c)(3)); small businesses; for-profit entities (including those other than small businesses); and multiple levels of government (state, county, city/township, special district governments, and public housing authorities/Indian housing authorities).
Were tribal governments eligible?
Yes. The FOA permitted applications from tribal governments that are federally recognized and those other than federally recognized.
Were independent school districts eligible?
Yes. Independent school districts were listed among eligible applicants.
Could non-U.S. or foreign organizations apply?
Yes. NIH explicitly allowed non-U.S. entities and foreign institutions to apply, as well as foreign components of U.S. organizations, consistent with NIH policy.
Did the FOA encourage participation by specific institution types?
The eligibility section highlighted inclusion of organizations such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISIs, as well as faith-based and community-based organizations and eligible federal agencies.
What was the scientific emphasis: biological discovery or measurement technology?
The FOA centered on developing and validating measurement approaches rather than only generating biological findings.
What did "develop and validate" mean for proposed technologies?
It implied that proposed technologies were expected to move beyond concept-stage ideas and demonstrate credible performance characteristics such as reproducibility, sensitivity, specificity, resolution, quantitative accuracy, scalability, and suitability for real biological samples.
What kinds of genome organization features were these tools meant to capture?
The program implicitly encompassed tools capable of capturing spatial genome features (such as distances or contacts among loci, higher-order folding patterns, compartmentalization, or nuclear positioning) and temporal behaviors (such as reorganization across time, cellular states, perturbations, or the cell cycle).
What methodological areas were explicitly called out?
The FOA explicitly called for physical, chemical, and biochemical approaches, indicating NIH interest in areas including (but not limited to) new labeling chemistries, improved crosslinking or proximity-capture strategies, novel molecular recording schemes, advances in microscopy or nanoscale measurement, and hybrid workflows integrating orthogonal measurement modalities.
Where could applicants find the full FOA text?
The full FOA text was available on the NIH grants site at: http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-14-007.html
Who was the contact for access or linking problems?
For access or linking problems, the contact listed was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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