Opportunity Information: Apply for PA 16 332

  • The HHS-NIH11 in the education, food and nutrition, health sector is offering a public funding opportunity titled "Nutrigenetics and Nutrigenomics Approaches for Nutrition Research (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.321, 93.393, 93.847,.
  • This funding opportunity was created on Jun 15, 2016 and posted on Jun 15, 2016.
  • Applicants must submit their applications by Sep 07, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for PA 16 332

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Opportunity Summary:

Nutrigenetics and Nutrigenomics Approaches for Nutrition Research (R01) is a discretionary grant opportunity from the U.S. Department of Health and Human Services, National Institutes of Health (HHS-NIH11), released under Funding Opportunity Number PA 16-332. The program uses the NIH R01 mechanism, which is the standard investigator-initiated research project grant meant to support hypothesis-driven studies that can produce strong, publishable findings and move a field forward. This FOA sits at the intersection of education, food and nutrition, and health, and it is linked to multiple CFDA program areas (93.213, 93.321, 93.393, 93.847), reflecting its cross-cutting relevance across NIH institutes and nutrition-related research portfolios.

The central goal of the announcement is to encourage nutrition research that meaningfully incorporates nutrigenetics and/or nutrigenomics. In practical terms, this means supporting studies that examine how genetic variation affects responses to diet (nutrigenetics) and how diet influences gene expression and related molecular pathways (nutrigenomics). The FOA emphasizes applying modern omics approaches, such as genomics, transcriptomics, epigenomics, proteomics, metabolomics, and related high-throughput or systems biology methods, to better understand diet-health relationships. A key point is that the opportunity is not just about adding an omics assay to a nutrition study; it is about using omics in a way that strengthens study design, improves measurement of biological response, and helps explain mechanisms that connect dietary exposures to health outcomes.

Another major theme is collaboration. The announcement explicitly promotes collaborative interaction between nutrition researchers and experts in omics technologies. That signals NIH interest in interdisciplinary teams where nutrition expertise (dietary assessment, interventions, nutrient metabolism, clinical or population nutrition) is integrated with specialized capability in omics generation, analysis, interpretation, and bioinformatics. The intent is to improve the quality and rigor of nutrigenetics/nutrigenomics work by pairing strong nutrition science with appropriate technical and analytical expertise, which is often essential for handling complex, high-dimensional datasets and for avoiding common pitfalls like underpowered genetic analyses, batch effects, or misinterpretation of association signals.

Eligibility is broad and includes many types of applicants that commonly participate in NIH research. Eligible organizations include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions where specified); for-profit organizations other than small businesses; small businesses; and other entities as allowed under NIH policy and any additional eligibility guidance referenced in the full FOA text. This wide eligibility is consistent with NIH practice for R01 opportunities and is intended to allow applications from academic settings, research institutes, government entities, and qualified private-sector groups that have the scientific capability and infrastructure to conduct rigorous biomedical and behavioral research.

From an administrative standpoint, the opportunity was created and posted on June 15, 2016, with an original and current closing date listed as September 7, 2019. While award ceiling and expected award counts are not specified in the provided data, that is not unusual for NIH FOAs, since budgets and award numbers often depend on annual appropriations, institute priorities, and the strength of the submitted applications. As an R01, projects are typically multi-year and budgeted according to the actual needs of the proposed research, subject to NIH policies and institute-specific guidelines.

Overall, this FOA is aimed at advancing nutrition science by bringing genetic and genomic tools to bear on questions like why individuals respond differently to the same diet, how dietary patterns influence molecular pathways tied to disease risk, and how omics data can sharpen exposure measurement, identify biomarkers, and clarify mechanisms. The emphasis on collaboration is a clear signal that competitive applications should demonstrate not only a strong nutrition question but also credible expertise and a coherent plan for omics data generation, analysis, and interpretation in a way that directly serves the nutrition research aims.

FAQs: Nutrigenetics and Nutrigenomics Approaches for Nutrition Research (R01) - PA 16-332

What is the name of this grant opportunity?

The opportunity is titled "Nutrigenetics and Nutrigenomics Approaches for Nutrition Research (R01)."

Which agency is offering this funding opportunity?

It is offered by the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH), identified as HHS-NIH11 in the provided information.

What is the Funding Opportunity Number (FOA number)?

The Funding Opportunity Number is PA 16-332.

What type of grant mechanism does this FOA use?

This FOA uses the NIH R01 mechanism, which is the standard investigator-initiated research project grant designed to support hypothesis-driven studies.

What kinds of studies is an NIH R01 intended to support under this announcement?

The announcement describes the R01 as supporting hypothesis-driven studies that can produce strong, publishable findings and help move a field forward.

What is the central goal of this funding announcement?

The central goal is to encourage nutrition research that meaningfully incorporates nutrigenetics and/or nutrigenomics as part of the study design and scientific aims.

What does "nutrigenetics" mean in the context of this FOA?

Nutrigenetics refers to research that examines how genetic variation affects responses to diet.

What does "nutrigenomics" mean in the context of this FOA?

Nutrigenomics refers to research that examines how diet influences gene expression and related molecular pathways.

What scientific approaches does the FOA emphasize?

The FOA emphasizes applying modern omics approaches and related high-throughput or systems biology methods to improve understanding of diet-health relationships.

Which omics areas are specifically mentioned?

The announcement mentions genomics, transcriptomics, epigenomics, proteomics, metabolomics, and related approaches.

Is it enough to simply add an omics assay to an existing nutrition study?

No. The FOA emphasizes that the opportunity is not just about adding an omics assay; it is about using omics in a way that strengthens the study design, improves measurement of biological response, and helps explain mechanisms connecting dietary exposures to health outcomes.

What does the FOA indicate about collaboration and team composition?

The FOA explicitly promotes collaborative interaction between nutrition researchers and experts in omics technologies, signaling interest in interdisciplinary teams that combine nutrition expertise with omics generation, analysis, interpretation, and bioinformatics capability.

Why does the FOA highlight collaboration with omics experts?

Based on the provided information, the intent is to improve the quality and rigor of nutrigenetics/nutrigenomics work by pairing strong nutrition science with appropriate technical and analytical expertise, which is important for handling complex, high-dimensional datasets and avoiding common pitfalls.

What kinds of pitfalls does the FOA suggest strong expertise can help avoid?

The provided description references pitfalls such as underpowered genetic analyses, batch effects, or misinterpretation of association signals.

What broad research areas does this FOA sit at the intersection of?

The FOA sits at the intersection of education, food and nutrition, and health.

Which CFDA program areas are linked to this opportunity?

The opportunity is linked to multiple CFDA program areas: 93.213, 93.321, 93.393, and 93.847.

What does it mean that multiple CFDA areas are linked to this FOA?

In the provided description, the multiple CFDA links reflect cross-cutting relevance across NIH institutes and nutrition-related research portfolios.

Who is eligible to apply?

Eligibility is described as broad and includes many organization types that commonly participate in NIH research, spanning government entities, educational institutions, nonprofit organizations, for-profit organizations (including those other than small businesses), small businesses, and certain tribal and housing authorities, consistent with NIH policy and any additional guidance referenced in the full FOA text.

Are state and local governments eligible?

Yes. Eligible organizations include state governments, county governments, city/township governments, special district governments, and independent school districts.

Are colleges and universities eligible?

Yes. Eligible organizations include public and state-controlled institutions of higher education and private institutions of higher education.

Are tribal entities eligible?

Yes. Eligible organizations include federally recognized Native American tribal governments and other Native American tribal organizations.

Are nonprofit organizations eligible?

Yes. Eligible organizations include nonprofit organizations with or without 501(c)(3) status, with the note in the provided information that certain exclusions may apply where higher education institutions are specified.

Are for-profit organizations eligible?

Yes. Eligible organizations include for-profit organizations other than small businesses, and small businesses are also listed as eligible.

Are public housing authorities eligible?

Yes. Public housing authorities and Indian housing authorities are included in the eligibility list.

When was this funding opportunity created and posted?

The opportunity was created and posted on June 15, 2016.

What is the closing date for this opportunity?

The provided information lists an original and current closing date of September 7, 2019.

Does the provided information specify an award ceiling?

No. The provided information states that an award ceiling is not specified.

Does the provided information specify the expected number of awards?

No. The provided information states that expected award counts are not specified.

Why might award ceilings and award counts not be listed for an NIH FOA?

The description notes that this is not unusual for NIH FOAs because budgets and award numbers often depend on annual appropriations, institute priorities, and the strength of submitted applications.

How are R01 project budgets typically determined?

Based on the provided information, R01 projects are typically budgeted according to the actual needs of the proposed research, subject to NIH policies and institute-specific guidelines.

What kinds of research questions does this FOA aim to advance?

The FOA is aimed at advancing questions such as why individuals respond differently to the same diet, how dietary patterns influence molecular pathways tied to disease risk, and how omics data can sharpen exposure measurement, identify biomarkers, and clarify mechanisms.

What should a competitive application clearly demonstrate, according to the description provided?

The description emphasizes that competitive applications should demonstrate both a strong nutrition question and credible expertise with a coherent plan for omics data generation, analysis, and interpretation that directly serves the nutrition research aims.

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