Opportunity Information: Apply for PA 06 136
Apply for PA 06 136
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Nutrition and Diet in the Causation, Prevention, and Management of Heart Failure (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research 93.837 Cardiovascular Diseases Research 93.866 Aging Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Mar 3, 2006.
- Applicants must submit their applications by May 7, 2009 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Public and State controlled institutions of higher education Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Public housing authorities/Indian housing authorities County governments Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification).
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government are eligible to apply. Faith based or community based organizations Units of State Tribal government Units of Local Tribal government
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Opportunity Summary:
The NIH funding opportunity "Nutrition and Diet in the Causation, Prevention, and Management of Heart Failure (R21)" (Funding Opportunity Number PA-06-136) supports early-stage, investigator-initiated research focused on how nutrition and dietary factors contribute to the development of cardiomyopathies and heart failure, and how dietary approaches might help prevent these conditions or improve outcomes once heart failure is present. The core emphasis is on building a stronger scientific foundation that can lead to practical prevention strategies for people at high risk and more rational, evidence-based nutritional management for patients across different stages of heart failure. The announcement makes clear that this is not limited to one narrow slice of research; it invites a broad range of scientifically rigorous projects designed to test well-defined hypotheses in either animal models or human populations, with the expectation that the work meaningfully advances understanding of diet-related mechanisms or interventions relevant to heart failure.
In terms of scientific scope, the FOA explicitly welcomes basic, translational, and applied research, especially when it is interdisciplinary. That means projects could range from mechanistic studies that probe how specific nutrients, dietary patterns, or metabolic pathways affect cardiac structure and function, to translational efforts that connect lab findings to clinically relevant biomarkers or physiological endpoints, to applied studies that test dietary interventions, adherence strategies, or nutrition-based management approaches in real-world or clinical settings. The unifying theme is the role of diet and nutrition in (1) causation, (2) prevention, and (3) treatment/management of cardiomyopathies and heart failure, with a strong preference for rigorous designs and clear hypothesis testing rather than purely descriptive work.
This opportunity uses the NIH R21 mechanism, which is typically intended for exploratory or developmental research that can generate new insights, pilot data, or proof-of-concept findings. The listed award ceiling is $200,000, signaling that projects should be appropriately scoped for a smaller, targeted study rather than a large definitive clinical trial. Cost sharing or matching is not required, which lowers barriers for organizations that may not have additional funds to contribute.
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations other than small businesses, and a wide variety of government entities (state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities). Tribal governments and tribal organizations are included, and the FOA also states that foreign institutions are eligible to apply. In addition, eligible federal agencies may apply, and faith-based and community-based organizations are included in the eligibility language. Anyone considering applying would still need to confirm any institute- or program-specific requirements in the full announcement, but the headline message is that NIH intended this to be accessible to a wide range of research-performing organizations.
From an administrative standpoint, the opportunity falls under the NIH (Agency Name: National Institutes of Health) and is categorized as discretionary grant funding. The activity categories and related CFDA numbers indicate relevance across nursing research (93.361), cardiovascular diseases research (93.837), and aging research (93.866), which fits the reality that heart failure is both a cardiovascular condition and a major issue in older populations, and that nutrition and self-management often overlap with nursing and behavioral health research domains.
Timing details show it was originally posted March 3, 2006, with multiple receipt dates referenced in the full announcement, and a current closing date listed as May 7, 2009, with the archive date June 7, 2009. In practical terms, those dates indicate this specific posting is historical and was active during that period, although similar NIH initiatives may reappear in updated forms. For the authoritative details, the FOA points applicants to the full announcement page hosted by NIH: http://grants.nih.gov/grants/guide/pa-files/PA-06-136.html. The contact information provided is the NIH Office of Extramural Research (OER) webmaster email for technical access or linking issues (FBOWebmaster@OD.NIH.GOV), which is mainly for troubleshooting rather than scientific or programmatic questions.
Overall, this FOA is best understood as a targeted invitation for innovative, well-designed exploratory studies that connect nutrition and dietary exposures or interventions to heart failure risk, disease mechanisms, progression, and patient management. The intended payoff is a stronger evidence base that can eventually inform prevention for high-risk individuals and improve nutrition-focused care strategies for patients living with heart failure.
FAQs: Nutrition and Diet in the Causation, Prevention, and Management of Heart Failure (R21) (PA-06-136)
What is this NIH funding opportunity?
This is an NIH discretionary grant funding opportunity titled "Nutrition and Diet in the Causation, Prevention, and Management of Heart Failure (R21)" under Funding Opportunity Number PA-06-136. It supports early-stage, investigator-initiated research on how nutrition and dietary factors contribute to cardiomyopathies and heart failure, and how dietary approaches might help prevent heart failure or improve outcomes for people who already have it.
What is the main purpose of the FOA?
The core purpose is to strengthen the scientific foundation linking diet and nutrition to (1) causation, (2) prevention, and (3) treatment/management of cardiomyopathies and heart failure, with the goal of enabling practical prevention strategies for high-risk individuals and more evidence-based nutritional management across different stages of heart failure.
What research topics are encouraged?
The FOA encourages scientifically rigorous projects that test well-defined hypotheses about nutrition and diet as they relate to heart failure. It explicitly welcomes a broad range of projects, as long as they meaningfully advance understanding of diet-related mechanisms or interventions relevant to heart failure.
Does the FOA focus only on prevention, or also on treatment and management?
It covers all three: causation, prevention, and treatment/management. That includes studying how dietary factors contribute to disease development, how dietary approaches might reduce risk, and how nutrition-based strategies could improve outcomes once heart failure is present.
Is this limited to a narrow research area?
No. The announcement states it is not limited to one narrow slice of research and invites a broad range of scientifically rigorous projects, including work in animal models or human populations.
What types of research approaches are allowed (basic, translational, applied)?
The FOA explicitly welcomes basic, translational, and applied research, especially when it is interdisciplinary. Projects can range from mechanistic studies of nutrients and pathways to applied studies of dietary interventions in clinical or real-world settings.
Can studies be conducted in animals or humans?
Yes. The FOA expects well-defined hypothesis testing in either animal models or human populations.
What does NIH mean by "interdisciplinary" in this context?
Based on the scope described, interdisciplinary work could include integrating nutrition science with cardiovascular biology, metabolism, clinical cardiology, aging research, nursing, behavioral strategies for adherence, and related fields, as long as the research rigorously addresses diet-related mechanisms or interventions relevant to heart failure.
Are purely descriptive studies responsive to this opportunity?
The FOA emphasizes rigorous designs and clear hypothesis testing rather than purely descriptive work, indicating descriptive-only projects would be less aligned with the stated preference.
What is the funding mechanism?
This opportunity uses the NIH R21 mechanism, which is typically intended for exploratory or developmental research designed to generate new insights, pilot data, or proof-of-concept findings.
What is the award ceiling?
The listed award ceiling is $200,000, which signals projects should be scoped as smaller, targeted exploratory studies rather than large, definitive clinical trials.
Is cost sharing or matching required?
No. The opportunity states that cost sharing or matching is not required.
Who is eligible to apply?
Eligibility is broad and includes many domestic and non-domestic organizations. The FOA lists eligible applicants such as public and private institutions of higher education; nonprofit organizations (including 501(c)(3) and non-501(c)(3)); for-profit organizations other than small businesses; and various government entities.
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are listed as eligible.
Are small businesses eligible?
The eligibility list explicitly mentions for-profit organizations other than small businesses, which indicates small businesses are not included in the eligibility statement provided in this summary.
Are foreign (non-U.S.) institutions eligible?
Yes. The FOA states that foreign institutions are eligible to apply.
Are tribal governments and tribal organizations eligible?
Yes. Tribal governments and tribal organizations are included in the eligibility language.
Are faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations are included in the eligibility language.
What types of government entities are eligible?
The FOA lists a wide variety of government entities as eligible, including state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Can federal agencies apply?
Yes. Eligible federal agencies may apply.
Which NIH agency is associated with this opportunity?
The agency name provided is the National Institutes of Health (NIH).
How is this opportunity categorized in federal assistance terms?
It is categorized as discretionary grant funding.
Which CFDA numbers are associated with this FOA, and what do they imply?
The activity categories and related CFDA numbers listed indicate relevance across nursing research (93.361), cardiovascular diseases research (93.837), and aging research (93.866). This aligns with heart failure as a cardiovascular condition, its importance in older populations, and the overlap of nutrition and self-management with nursing and behavioral health domains.
When was this funding opportunity posted, and is it still active?
The FOA was originally posted on March 3, 2006. A closing date is listed as May 7, 2009, with an archive date of June 7, 2009. Those dates indicate this specific posting is historical and was active during that period.
Where can applicants find the authoritative full announcement?
The FOA points to the NIH full announcement page at http://grants.nih.gov/grants/guide/pa-files/PA-06-136.html.
Who is listed as the contact for technical issues?
The contact information provided is the NIH Office of Extramural Research (OER) webmaster email: FBOWebmaster@OD.NIH.GOV. It is described as primarily for technical access or linking issues rather than scientific or programmatic questions.
What kinds of outcomes is NIH aiming for through this FOA?
The intended payoff described is a stronger evidence base that can eventually inform prevention for high-risk individuals and improve nutrition-focused care strategies for patients living with heart failure, including more rational and evidence-based nutritional management across disease stages.
Does the FOA encourage studies on dietary interventions and adherence?
Yes. The scope explicitly includes applied studies that test dietary interventions, adherence strategies, or nutrition-based management approaches in real-world or clinical settings.
Does this FOA allow biomarker or physiology-focused translational endpoints?
Yes. The FOA welcomes translational efforts that connect lab findings to clinically relevant biomarkers or physiological endpoints.
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