Opportunity Information: Apply for PA 11 245
Apply for PA 11 245
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Obesity and Asthma Awareness and Management (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research.
- This funding opportunity was created on Aug 8, 2014 and posted on Jul 7, 2011.
- Applicants must submit their applications by Aug 8, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Small businesses Public and State controlled institutions of higher education Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) County governments Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:
The Obesity and Asthma Awareness and Management (R01) funding opportunity (PA 11-245) is a discretionary NIH grant program led by the National Institute of Nursing Research (NINR) that aims to push the science forward on how asthma and obesity are connected. The announcement is grounded in a clear public health problem: rates of both asthma and obesity have climbed markedly over recent decades, and a large body of research has repeatedly observed that the two conditions are associated. What remains unsettled is why that association exists, what biological and environmental mechanisms drive it, and how that knowledge can be used to improve prevention and treatment strategies.
A central theme of the opportunity is early life risk. The announcement highlights that both asthma and obesity often begin developing in childhood, which makes early-life exposures an especially important and still underexplored part of the puzzle. Proposed studies are encouraged to examine shared early exposures that might predispose someone to both conditions, such as prenatal and infant influences, childhood environmental factors, or other early developmental pathways that could shape immune function, metabolism, airway biology, or patterns of inflammation. In practical terms, the program is looking for research that can help explain whether common early experiences set the stage for both asthma and excess weight gain, and if so, through what intermediate steps.
Beyond observational links, the announcement explicitly invites mechanistic work, including studies that dig into molecular pathways connecting asthma and obesity. This includes research focused on biological processes that could plausibly bridge respiratory disease and metabolic dysfunction, such as inflammatory signaling networks, immune modulation, hormonal and endocrine pathways, genetic and epigenetic regulation, oxidative stress, and other cellular mechanisms. The emphasis is on moving from correlation to explanation by identifying pathways that can clarify directionality, causality, and potential targets for intervention.
Intervention research is also strongly encouraged. The FOA signals interest in studies that target asthma or obesity and then measure effects on the other condition, along with the mechanisms that might explain any changes observed. For example, an intervention aimed at improving asthma control could be evaluated for downstream effects on physical activity, sleep, medication use, or metabolic outcomes, while an obesity-focused intervention could be tested for effects on asthma symptoms, exacerbation frequency, lung function, or airway inflammation. The key is that projects should not stop at reporting whether an intervention "works," but should also try to explain how and why it works, using plausible biological or behavioral mechanisms.
In terms of administrative details, this opportunity uses the R01 research project grant mechanism, does not require cost sharing or matching, and falls under the NIH activity category spanning education and health, with CFDA number 93.361 (Nursing Research). The posting date listed is July 7, 2011, and the record indicates the opportunity has been archived, with historical closing dates in 2014. While that archival status means it is not an active solicitation today, the summary still reflects what NINR sought under this specific announcement and can be useful for understanding the type of science NIH has been willing to support in this area.
Eligibility is broad and includes many types of organizations that commonly apply for NIH funding. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profit entities), state and local governments, county and city governments, independent school districts, special district governments, and various tribal governments and tribal organizations. The eligibility language also extends to mission-specific and historically underserved institutions and communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations. Importantly, the announcement allows participation by non-U.S. entities (foreign organizations), as well as U.S. territories or possessions, regional organizations, eligible federal agencies, and foreign components of U.S. organizations, which opens the door to international or multinational work where scientifically justified.
For official reference and full requirements, the announcement points applicants to the NIH Grants Guide page for PA 11-245 (http://grants.nih.gov/grants/guide/pa-files/PA-11-245.html). Technical access issues are routed to the NIH Office of Extramural Research (OER) webmaster via FBOWebmaster@OD.NIH.GOV, reflecting standard NIH support channels for navigating the electronic posting rather than scientific program questions.
Frequently Asked Questions (FAQs): Obesity and Asthma Awareness and Management (R01) - PA 11-245
What is the Obesity and Asthma Awareness and Management (R01) funding opportunity (PA 11-245)?
PA 11-245 is a discretionary NIH funding opportunity that used the R01 research project grant mechanism to support research on how asthma and obesity are connected. It was led by the National Institute of Nursing Research (NINR) and emphasized moving beyond observed associations to explain underlying mechanisms and identify ways to improve prevention and treatment strategies.
Which NIH institute led this program?
The opportunity was led by the National Institute of Nursing Research (NINR).
What public health problem does the announcement focus on?
The announcement is grounded in the rise of both asthma and obesity over recent decades, and the large body of research repeatedly observing an association between the two conditions. A key motivation is that the reasons for this association, and the mechanisms that drive it, remain unsettled.
What is the main scientific goal of the FOA?
The main goal is to push the science from correlation toward explanation by clarifying why asthma and obesity are associated, what biological and environmental mechanisms drive that relationship, and how that knowledge can improve prevention and treatment.
Does the FOA prioritize early-life risk factors?
Yes. A central theme is early life risk, emphasizing that asthma and obesity often begin developing in childhood. The program encouraged research on prenatal, infant, and childhood exposures and developmental pathways that could predispose individuals to both conditions.
What kinds of early-life exposures or pathways were encouraged for study?
Proposed studies were encouraged to examine shared early exposures such as prenatal and infant influences, childhood environmental factors, and other early developmental pathways that might shape immune function, metabolism, airway biology, or patterns of inflammation.
Is mechanistic or molecular research within scope?
Yes. The announcement explicitly invited mechanistic work, including studies that investigate molecular pathways connecting asthma and obesity.
What biological mechanisms were highlighted as potential links between asthma and obesity?
The FOA highlighted multiple plausible bridging processes, including inflammatory signaling networks, immune modulation, hormonal and endocrine pathways, genetic and epigenetic regulation, oxidative stress, and other cellular mechanisms.
Is intervention research encouraged under this program?
Yes. Intervention research was strongly encouraged, particularly studies that target asthma or obesity and measure effects on the other condition.
What kinds of intervention designs did the FOA describe?
The FOA described interventions aimed at improving asthma control that could be evaluated for downstream effects on physical activity, sleep, medication use, or metabolic outcomes. It also described obesity-focused interventions that could be tested for effects on asthma symptoms, exacerbation frequency, lung function, or airway inflammation.
Do projects need to explain how an intervention works, or only whether it works?
The FOA emphasized that projects should not stop at reporting whether an intervention works. Studies were encouraged to also examine how and why changes occur using plausible biological or behavioral mechanisms.
What grant mechanism does this opportunity use?
This opportunity uses the NIH R01 research project grant mechanism.
Is cost sharing or matching required?
No. The opportunity does not require cost sharing or matching.
What is the CFDA number associated with this announcement?
The CFDA number listed is 93.361 (Nursing Research).
When was this opportunity posted?
The posting date listed is July 7, 2011.
Is PA 11-245 currently open for applications?
No. The record indicates the opportunity has been archived, with historical closing dates in 2014. That archival status means it is not an active solicitation today.
Why might this archived announcement still be useful?
Even though it is archived, it still reflects the types of scientific questions and approaches NINR sought to support under this specific announcement. It can be useful for understanding the kind of science NIH has been willing to fund in the area of asthma-obesity connections.
Who was eligible to apply (in general terms)?
Eligibility was broad and included many organization types commonly eligible for NIH funding, including higher education institutions, nonprofit and for-profit organizations, and various government entities.
Are public and private institutions of higher education eligible?
Yes. Public and private institutions of higher education were included as eligible applicants.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations were eligible, including both 501(c)(3) and non-501(c)(3) entities.
Are for-profit organizations eligible?
Yes. For-profit organizations were eligible, including small businesses and other for-profit entities.
Are state and local government entities eligible?
Yes. Eligibility included state governments, local governments, county governments, and city or township governments.
Are school districts or special district governments eligible?
Yes. Independent school districts and special district governments were included among eligible applicants.
Are tribal governments and tribal organizations eligible?
Yes. The eligibility language included various tribal governments and tribal organizations.
Does the FOA explicitly include historically underserved or mission-specific institutions?
Yes. The announcement specifically listed Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations.
Are non-U.S. (foreign) organizations allowed to participate?
Yes. The announcement allows participation by non-U.S. entities (foreign organizations). It also included U.S. territories or possessions, regional organizations, eligible federal agencies, and foreign components of U.S. organizations.
Where can applicants find the official NIH posting for PA 11-245?
The announcement points to the NIH Grants Guide page for PA 11-245: http://grants.nih.gov/grants/guide/pa-files/PA-11-245.html
Who should be contacted for technical access issues with the posting?
Technical access issues are routed to the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Does the provided information include a scientific contact for program questions?
No. The information provided only mentions the OER webmaster contact for technical access issues related to the electronic posting, not scientific or programmatic questions.
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| Social and Behavioral Research on the Elderly in Disasters (R21) Apply for PA 11 265 Funding Number: PA 11 265 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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| Pre Application for the 2012 NIDA Translational Avant Garde Award for Medication Development for the Treatment of Substance Use Disorders (X02) Apply for PAR 11 269 Funding Number: PAR 11 269 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Pre Application for the FY12 NIDA Avant Garde Award Program for HIV/AIDS Research (X02) Apply for PAR 11 256 Funding Number: PAR 11 256 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| FY12 NIDA Avant Garde Award Program for HIV/AIDS Research (DP1) Apply for RFA DA 12 011 Funding Number: RFA DA 12 011 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Centers of Biomedical Research Excellence (COBRE) (P20) Apply for PAR 11 286 Funding Number: PAR 11 286 Agency: National Institutes of Health Category: Education Health Funding Amount: $300,000 |
| Pilot studies in Pancreatic Cancer (R21) Apply for PA 11 297 Funding Number: PA 11 297 Agency: National Institutes of Health Category: Education Health Funding Amount: $275,000 |
| Pilot studies in Pancreatic Cancer (R03) Apply for PA 11 298 Funding Number: PA 11 298 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Drug Abuse Prevention Intervention Research (R03) Apply for PA 11 313 Funding Number: PA 11 313 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Drug Abuse Prevention Intervention Research (R01) Apply for PA 11 311 Funding Number: PA 11 311 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Drug Abuse Prevention Intervention Research (R21) Apply for PA 11 312 Funding Number: PA 11 312 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Human Health and Heredity in Africa (H3Africa) Research Grants (U01) Apply for RFA RM 11 009 Funding Number: RFA RM 11 009 Agency: National Institutes of Health Category: Education Health Funding Amount: $275,000 |
| Scalable Assays for Unbiased In Vitro Analysis of Neurobiological Function (R21/R33) Apply for PAR 11 319 Funding Number: PAR 11 319 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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