Opportunity Information: Apply for PA 14 316
Apply for PA 14 316
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Obesity and Asthma Awareness and Self Management (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research.
- This funding opportunity was created on Aug 8, 2014 and posted on Aug 8, 2014.
- Applicants must submit their applications by Sep 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Special district governments Public and State controlled institutions of higher education City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Private institutions of higher education State governments Independent school districts Small businesses County governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Obesity and Asthma Awareness and Self Management (R01) funding opportunity (PA 14-316) is a National Institutes of Health (NIH) research grant program designed to spur new studies on how asthma and obesity are connected, and how that connection affects day-to-day self-management and the ability to achieve good disease control. The central idea behind the announcement is that asthma and obesity have both increased substantially over recent decades, and while many studies have observed that the two conditions frequently occur together, the reasons why they are linked remain unclear. NIH is specifically looking for research that moves beyond simply confirming an association and instead explains the underlying mechanisms and practical implications, particularly those tied to patient behavior, self-care routines, symptom monitoring, medication adherence, lifestyle choices, and broader self-management skills that influence outcomes.
A key theme of this opportunity is the life-course perspective. Because both asthma and obesity often begin early in life, the announcement emphasizes the need to understand shared early-life exposures and developmental pathways that may set the stage for both conditions and shape how they evolve as a person transitions from childhood to adolescence and into adulthood. This could include work examining environmental exposures, family and community contexts, social determinants, diet and activity patterns, stress, sleep, infections, allergen exposures, and other factors that might simultaneously influence respiratory health, weight trajectories, and the habits or constraints that determine how well someone can manage chronic disease over time. The grant encourages studies that clarify not only biological pathways but also how those pathways interact with lived experience and the real-world challenges of maintaining asthma control and healthy weight.
The announcement also encourages mechanistic research, including studies that investigate molecular and physiological pathways that may link obesity and asthma, as long as the proposal clearly connects those mechanisms to self-management and control. In practice, this means projects can explore inflammation, metabolic changes, immune responses, hormonal signaling, airway mechanics, microbiome influences, or genetic and epigenetic factors, but they should also explain why the findings matter for patient-centered management. For example, a mechanistic study might be strengthened by showing how a biological pathway affects symptom burden, exercise tolerance, responsiveness to medications, or the ability to follow recommended management behaviors, and how that knowledge could inform better education, clinical guidance, or tailored interventions.
Intervention research is another priority area. NIH explicitly welcomes intervention studies that target asthma or obesity and then assess the effects on the other condition, along with plausible mechanisms of action and impacts on behavior. This could involve testing weight-management approaches to see whether asthma symptoms, exacerbations, lung function, or medication needs improve, or asthma-focused interventions to see whether better respiratory control supports physical activity and healthier weight outcomes. Importantly, the opportunity highlights interest in understanding how interventions work, not just whether they work, including behavioral mechanisms such as improved self-efficacy, better adherence, changes in health literacy, reduced barriers to exercise, or improved engagement with care plans.
From an administrative standpoint, this is an NIH R01 mechanism, which generally supports substantial, hypothesis-driven research projects and can accommodate a wide range of study designs, from observational cohorts to clinical or community-based interventions, as long as the work is rigorous and aligned with the program purpose. The opportunity falls under the health and education-related funding activity categories and is associated with CFDA 93.361 (Nursing Research). There is no cost-sharing or matching requirement listed, which means applicants are not expected to contribute non-federal matching funds as a condition of award.
Eligibility for this announcement is broad, reflecting NIH’s typical openness to many types of research institutions and organizations. Eligible applicants include public and private institutions of higher education, nonprofits (including 501(c)(3) organizations and certain nonprofits without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), and a wide range of government entities such as state governments, counties, cities or townships, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The eligibility listing also explicitly includes federally recognized tribal governments and other tribal organizations, U.S. territories or possessions, and a variety of mission-specific institutions and community-based organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). The announcement also notes eligibility for certain non-U.S. entities (foreign organizations) and regional organizations, which is relevant for teams studying asthma and obesity across diverse populations and settings.
The opportunity was posted on August 8, 2014, with an original and current closing date of September 7, 2017, and an archive date of October 8, 2017, indicating it is no longer open for new applications under that specific announcement. The full archived announcement is referenced via the NIH grants guide link (http://grants.nih.gov/grants/guide/pa-files/PA-14-316.html). For technical issues accessing the announcement, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, PA 14-316 is best understood as a call for research that connects the dots between biology, behavior, and real-world management in people affected by both asthma and obesity, with special emphasis on how these conditions develop from early life and how interventions can improve outcomes by addressing both physiological mechanisms and self-management behaviors.
Frequently Asked Questions (FAQs)
What is the Obesity and Asthma Awareness and Self Management (R01) opportunity (PA 14-316)?
PA 14-316 is an NIH research grant funding opportunity using the R01 mechanism. It was designed to stimulate new research on how asthma and obesity are connected, and how that connection affects day-to-day self-management and the ability to achieve good disease control.
What is the main purpose of this funding announcement?
The main purpose is to move research beyond simply showing that asthma and obesity occur together. NIH sought studies that explain underlying mechanisms and practical implications, especially those related to self-care behaviors and real-world disease management.
What kinds of self-management topics does the announcement emphasize?
The announcement emphasizes research tied to patient behavior and self-care routines, including symptom monitoring, medication adherence, lifestyle choices, and broader self-management skills that influence asthma control and weight-related outcomes.
Why does NIH focus on the asthma-obesity connection in this opportunity?
The opportunity is based on the observation that both asthma and obesity have increased substantially over recent decades and frequently co-occur. NIH highlighted that the reasons for this link remain unclear and called for research that clarifies why and how the connection occurs and what it means for managing health day to day.
Does the announcement encourage research from a life-course perspective?
Yes. A key theme is a life-course perspective, recognizing that asthma and obesity often begin early in life. The announcement encourages studies that examine shared early-life exposures and developmental pathways and how these factors influence disease progression and self-management from childhood through adulthood.
What early-life or developmental factors are mentioned as relevant?
Examples mentioned include environmental exposures, family and community contexts, social determinants, diet and activity patterns, stress, sleep, infections, allergen exposures, and other factors that may shape respiratory health, weight trajectories, and the habits or constraints that affect chronic disease management over time.
Are biological or mechanistic studies allowed under this opportunity?
Yes. The announcement encourages mechanistic research (molecular and physiological pathways) that may link obesity and asthma, as long as the proposal clearly connects those mechanisms to self-management and disease control.
What kinds of biological mechanisms are specifically mentioned?
Examples include inflammation, metabolic changes, immune responses, hormonal signaling, airway mechanics, microbiome influences, and genetic or epigenetic factors. The announcement stresses that these mechanisms should be tied to patient-centered management relevance.
How should mechanistic findings be connected to patient outcomes or management?
The announcement suggests strengthening mechanistic studies by explaining how a pathway affects symptom burden, exercise tolerance, responsiveness to medications, or the ability to follow recommended management behaviors, and how this knowledge could inform education, clinical guidance, or tailored interventions.
Does NIH welcome intervention research in this program?
Yes. NIH explicitly welcomes intervention studies that target asthma or obesity and assess effects on the other condition, along with plausible mechanisms of action and impacts on behavior.
What are examples of intervention approaches described in the announcement?
Examples include testing weight-management approaches to see whether asthma symptoms, exacerbations, lung function, or medication needs improve, and testing asthma-focused interventions to see whether better respiratory control supports physical activity and healthier weight outcomes.
Is the program interested only in whether an intervention works?
No. The opportunity highlights interest in understanding how interventions work, not just whether they work. This includes investigating behavioral mechanisms such as self-efficacy, adherence, health literacy, barriers to exercise, or engagement with care plans.
What funding mechanism is used for PA 14-316?
This opportunity uses the NIH R01 mechanism, which typically supports substantial, hypothesis-driven research projects and can accommodate a wide range of rigorous study designs aligned with the program’s purpose.
What kinds of study designs can fit under an NIH R01 for this topic?
Based on the announcement description, projects could include observational cohorts as well as clinical or community-based interventions, provided they are rigorous and clearly aligned with connecting obesity, asthma, and self-management/disease control.
What funding activity categories are associated with this opportunity?
The opportunity falls under health and education-related funding activity categories.
What CFDA number is associated with this announcement?
The opportunity is associated with CFDA 93.361 (Nursing Research).
Is cost-sharing or matching required?
No. The listing indicates there is no cost-sharing or matching requirement, meaning applicants were not expected to provide non-federal matching funds as a condition of award.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include public and private institutions of higher education; nonprofits (including 501(c)(3) organizations and certain nonprofits without 501(c)(3) status); for-profit organizations (including small businesses and other for-profits); and many government entities.
Which government entities are included in the eligibility list?
The eligibility list includes state governments, counties, cities or townships, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. The eligibility description explicitly includes federally recognized tribal governments and other tribal organizations.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included in the eligibility listing.
Are mission-specific institutions such as HBCUs and HSIs included?
Yes. The eligibility listing explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), among other community-based organizations.
Are foreign organizations eligible to apply?
The announcement notes eligibility for certain non-U.S. entities (foreign organizations) and regional organizations.
Is this funding opportunity still open?
No. The opportunity was posted on August 8, 2014, with a closing date of September 7, 2017, and an archive date of October 8, 2017. That indicates it is no longer open for new applications under this specific announcement.
Where can the archived announcement be found?
The archived announcement is referenced via the NIH Grants Guide link: http://grants.nih.gov/grants/guide/pa-files/PA-14-316.html
Who should be contacted for technical issues accessing the announcement?
For technical issues accessing the announcement, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What is the overall research emphasis of PA 14-316?
Overall, it is a call for research that connects biology, behavior, and real-world management among people affected by both asthma and obesity, emphasizing early-life development and intervention approaches that address physiological mechanisms alongside self-management behaviors.
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