Opportunity Information: Apply for RFA HD 14 013
Apply for RFA HD 14 013
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Obstetric Fetal Pharmacology Research Centers (OPRC) (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Aug 14, 2014 and posted on Jul 15, 2014.
- Applicants must submit their applications by Dec 9, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,800,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $4,800,000.00 in funding.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments State governments County governments Special district governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Private institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The Obstetric Fetal Pharmacology Research Centers (OPRC) (U54) funding opportunity (RFA-HD-14-013) is a National Institutes of Health (NIH) cooperative agreement run through the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Its central aim is to support a small number of specialized, multicenter research centers focused on obstetric pharmacology, with a strong emphasis on translational work that connects basic science discoveries to real-world clinical use in pregnancy. The program is designed to bring together multidisciplinary teams, typically spanning basic scientists and clinical investigators, to build high-quality research programs that improve how medications are studied, selected, dosed, and monitored in pregnant women.
A defining feature of this opportunity is that awardees are expected to operate not just as individual centers, but as parts of a coordinated national network. The centers are meant to serve as national resources for clinical pharmacology research in women during both normal and complicated pregnancies. In practice, this means generating evidence that helps clinicians understand how pregnancy changes drug exposure and response, how medications affect the mother and the fetus, and how to use therapies more safely and effectively. The FOA highlights the full translational pathway: moving insights from the laboratory toward new treatments and improved therapeutic strategies, and also ensuring that findings from clinical studies and trials are translated into routine practice to ultimately improve maternal and fetal outcomes.
Because this is a U54 cooperative agreement rather than a standard grant, NICHD staff have an active role alongside the funded investigators. Center teams are expected to work closely with NICHD to facilitate collaborations and to encourage interaction within and among centers, which is intended to speed progress, reduce duplication, and help create shared approaches and resources across the network. The structure is meant to support collaboration-heavy research where coordinated planning, common protocols, and cross-site synergy can substantially increase impact compared with isolated projects.
From an administrative and funding standpoint, the opportunity was posted July 15, 2014, created August 14, 2014, with an original closing date of September 15, 2014, later extended to December 9, 2014, and an archive date of January 8, 2015. The estimated total funding listed is $4,800,000, with an award ceiling also noted as $4,800,000, and there is no cost-sharing or matching requirement. The CFDA number associated with this program is 93.865 (Child Health and Human Development Extramural Research). As an NIH opportunity in the health, income security, and social services activity category, it sits squarely in the biomedical and clinical research domain, specifically targeting gaps in evidence for medication use during pregnancy.
Eligibility is broad across U.S.-based organizations, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including 501(c)(3) and other nonprofits), small businesses, and certain governmental entities such as state, county, city or township governments, special district governments, public housing authorities/Indian housing authorities, and independent school districts. It also explicitly includes a range of institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and eligible federal agencies. At the same time, the FOA is clear that non-U.S. (foreign) organizations and foreign institutions are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed.
Overall, the OPRC (U54) opportunity is aimed at building a small, high-impact set of NICHD-partnered centers that can function collectively as a national engine for obstetric and fetal pharmacology research. The intended outcome is better evidence and better clinical decision-making around medication use in pregnancy, leading to safer and more effective treatments for pregnant patients and improved protection for fetal health. For full details, NIH provided an additional information link to the archived FOA at http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-14-013.html, with technical access issues directed to the NIH OER Webmaster (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs) - Obstetric Fetal Pharmacology Research Centers (OPRC) (U54)
What is the OPRC (U54) funding opportunity?
The Obstetric Fetal Pharmacology Research Centers (OPRC) (U54) opportunity (RFA-HD-14-013) is an NIH cooperative agreement run through the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). It supports a small number of specialized, multicenter research centers focused on obstetric pharmacology, with an emphasis on translational research related to medication use in pregnancy.
Which NIH Institute runs this program?
This program is run through NICHD (the Eunice Kennedy Shriver National Institute of Child Health and Human Development), part of the National Institutes of Health (NIH).
What is the main goal of the OPRC program?
The main goal is to build high-quality, collaborative research centers that improve how medications are studied, selected, dosed, and monitored in pregnant women, ultimately improving maternal and fetal outcomes.
What type of grant mechanism is this (U54), and what does that imply?
This opportunity uses the U54 cooperative agreement mechanism. Unlike a standard grant, NICHD staff are expected to have an active role alongside funded investigators, with close coordination intended to accelerate progress, reduce duplication, and support shared approaches and resources across the network.
What does "cooperative agreement" mean for how the project will be run?
Based on the FOA description, awardees are expected to work closely with NICHD to facilitate collaborations and encourage interaction within and among centers. The structure is designed for collaboration-heavy research where coordinated planning, common protocols, and cross-site synergy increase impact.
Is this meant to fund individual projects or coordinated centers?
It is intended to fund specialized research centers that operate as parts of a coordinated national network, not isolated projects. Centers are expected to function collectively and serve as national resources for clinical pharmacology research in pregnancy.
Is this opportunity focused on basic science, clinical research, or both?
Both. The program emphasizes translational work that connects basic science discoveries to clinical use in pregnancy, and also emphasizes translating clinical study and trial findings into routine practice.
What does the FOA mean by covering the "full translational pathway"?
The FOA highlights moving laboratory insights toward new treatments and improved therapeutic strategies, and also ensuring findings from clinical studies and trials are translated into routine practice to improve maternal and fetal outcomes.
What kinds of research questions is this program designed to address?
The program is designed to generate evidence on how pregnancy changes drug exposure and response, how medications affect the mother and the fetus, and how therapies can be used more safely and effectively during normal and complicated pregnancies.
What does it mean that the centers are "national resources"?
It means the centers are intended to support and strengthen clinical pharmacology research in pregnant women at a national level, operating as part of a coordinated network rather than functioning only for a local or single-institution purpose.
What kinds of teams are expected to apply?
The FOA emphasizes multidisciplinary teams, typically spanning basic scientists and clinical investigators, organized into specialized multicenter research centers.
What is the estimated total funding amount for this opportunity?
The estimated total funding listed is $4,800,000.
What is the award ceiling for this opportunity?
The award ceiling is noted as $4,800,000.
Is cost-sharing or matching required?
No. The opportunity states there is no cost-sharing or matching requirement.
What is the CFDA number for this program?
The CFDA number associated with this program is 93.865 (Child Health and Human Development Extramural Research).
How is this opportunity categorized in terms of activity area?
It is listed in the health, income security, and social services activity category, and the FOA content places it within biomedical and clinical research focused on medication use during pregnancy.
When was this funding opportunity posted?
It was posted on July 15, 2014.
When was the opportunity created?
It was created on August 14, 2014.
What was the original closing date and was it extended?
The original closing date was September 15, 2014, and it was later extended to December 9, 2014.
When was the opportunity archived?
The archive date is January 8, 2015.
Are non-U.S. (foreign) organizations eligible to apply?
No. The FOA states that non-U.S. (foreign) organizations and foreign institutions are not eligible to apply.
Are non-U.S. components of U.S. organizations eligible?
No. The FOA states that non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed under NIH policy?
No. The FOA indicates that foreign components (as defined by NIH policy) are not allowed.
What types of U.S.-based organizations are eligible?
Eligibility includes U.S.-based organizations such as public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including 501(c)(3) and other nonprofits), small businesses, and certain governmental entities (state, county, city or township governments, special district governments, public housing authorities/Indian housing authorities, and independent school districts).
Are minority-serving institutions specifically included as eligible?
Yes. The FOA explicitly includes institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly includes faith-based or community-based organizations among eligible applicants.
Are federal agencies eligible to apply?
Yes. The FOA notes that eligible federal agencies are included among eligible applicants.
Where can applicants find the full archived FOA text?
NIH provided an additional information link to the archived FOA at http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-14-013.html.
Who should be contacted for technical access issues related to the FOA?
Technical access issues are directed to the NIH OER Webmaster at FBOWebmaster@OD.NIH.GOV.
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