Opportunity Information: Apply for PAR 07 378
Apply for PAR 07 378
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Omics and Variable Responses to CAM Secondary Analysis of CAM Clinical Trials (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health 93.393 Cancer Cause and Prevention Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Jun 6, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Private institutions of higher education Public and State controlled institutions of higher education For profit organizations other than small businesses State governments Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities City or township governments Small businesses Independent school districts.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The NIH funding opportunity titled "Omics and Variable Responses to CAM Secondary Analysis of CAM Clinical Trials (R21)" (Funding Opportunity Number PAR-07-378) supports exploratory, secondary analyses that try to explain why people respond differently to complementary and alternative medicine (CAM) interventions or to bioactive food component interventions. The central idea is to use modern "omics" approaches, such as genomics, proteomics, metabolomics, and related platforms, to identify biological differences among participants that may account for variability in treatment response. Rather than funding brand-new clinical trials, this announcement focuses on leveraging samples and data that already exist from ongoing or completed clinical studies, which makes it well-suited for investigators who can ask new mechanistic or responder/non-responder questions using archived specimens and trial datasets.
This FOA uses the NIH R21 mechanism, which is generally intended for early-stage, high-impact, or innovative projects where the goal is to establish feasibility, generate preliminary signals, or test a novel analytic approach. In parallel, NIH offered a companion announcement with the same scientific scope under the R01 mechanism (PAR-07-377), which would typically be used for more mature projects that require a larger scope or longer-term support. Under PAR-07-378 specifically, the award ceiling is listed as $200,000, reinforcing the smaller, exploratory nature of an R21 compared with an R01.
From a research content perspective, the projects envisioned here are about disentangling heterogeneous responses in CAM and nutrition-related interventions by connecting clinical outcomes to molecular profiles. That can include looking for biomarkers that predict who benefits, who does not, and who might experience adverse effects, as well as exploring biological pathways that could plausibly explain observed outcome differences. Because the work is secondary analysis, the key resource is access to well-characterized clinical trial samples (for example, blood, tissue, urine, or other biospecimens collected during the parent study) and the corresponding trial data needed to relate omics patterns to endpoints. The emphasis is on using these existing materials to produce new insight, rather than repeating primary data collection.
The opportunity is categorized as a discretionary grant and falls under health-related research and training programs, with CFDA numbers 93.213 (Research and Training in Complementary and Integrative Health) and 93.393 (Cancer Cause and Prevention Research). While the detailed scientific fit would depend on the parent clinical trial and the intervention being analyzed, the involvement of NCCAM (now known as NCCIH) and NCI signals strong interest in CAM-related interventions and bioactive food components, including those relevant to cancer prevention, causation, or supportive care contexts where such interventions are commonly studied.
Eligibility is broad and includes many domestic organization types, such as public and private institutions of higher education, nonprofits (including 501(c)(3) organizations), state and local governments, tribal governments and tribal organizations, special district governments, independent school districts, public housing authorities/Indian housing authorities, and for-profit organizations (including small businesses and other for-profits). The listing also notes that foreign institutions are eligible to apply, eligible federal agencies may apply, and faith-based or community-based organizations can apply, which is consistent with NIH’s wide applicant pool when the scientific and administrative requirements can be met. Cost sharing or matching is not required.
In terms of timing and administration, the FOA was posted June 6, 2007, with multiple receipt dates (meaning applications were accepted on more than one deadline, as specified in the full announcement). It was later archived on September 14, 2009, so it is not an active funding opportunity today, but it remains a useful reference point for the kind of NIH-supported work that combines clinical trial datasets with omics-driven secondary analyses to explain variable responses. The full announcement was hosted on the NIH Grants Guide website, and NIH provided standard webmaster contacts for technical access issues.
FAQs: Omics and Variable Responses to CAM Secondary Analysis of CAM Clinical Trials (R21) (PAR-07-378)
What is this NIH funding opportunity?
This NIH Funding Opportunity Announcement (FOA) is titled "Omics and Variable Responses to CAM Secondary Analysis of CAM Clinical Trials (R21)" and has the Funding Opportunity Number PAR-07-378. It supports exploratory research that uses existing clinical trial data and samples to study why people respond differently to complementary and alternative medicine (CAM) interventions or bioactive food component interventions.
What is the main goal of the FOA?
The main goal is to explain variable treatment responses (for example, responder vs. non-responder differences, and differences in adverse effects) by linking clinical outcomes from CAM or bioactive food component trials to modern molecular profiling ("omics") data. The intent is to identify biological differences among participants that may account for different outcomes.
What kinds of studies does it fund: new clinical trials or secondary analysis?
This FOA focuses on secondary analyses of existing or ongoing clinical studies. It is designed to leverage archived specimens and already-collected trial datasets rather than funding brand-new clinical trials or primary sample/data collection.
What does "omics" mean in the context of this FOA?
What is the R21 mechanism and what does it imply about project scope?
The FOA uses the NIH R21 mechanism, which is generally intended for exploratory, early-stage, innovative, or high-impact projects. Under an R21, the expectation is often to establish feasibility, generate preliminary signals, or test a novel analytic strategy rather than conduct a large, definitive program of work.
What is the award ceiling for this R21 opportunity?
The award ceiling listed for PAR-07-378 is $200,000, consistent with an R21 being smaller and more exploratory than many other NIH mechanisms.
Is there a related funding announcement for larger or more mature projects?
Yes. NIH offered a companion announcement with the same scientific scope under the R01 mechanism: PAR-07-377. The R01 is typically used for more mature projects that require a larger scope or longer-term support than an R21.
What research questions are considered a fit for this FOA?
Projects envisioned under this FOA focus on disentangling heterogeneous responses in CAM and nutrition-related interventions by connecting clinical endpoints to molecular profiles. Examples of fit-for-purpose question types described include identifying biomarkers that predict benefit or lack of benefit, identifying predictors of adverse effects, and exploring biological pathways that could plausibly explain observed differences in outcomes.
What kind of data and materials do applicants generally need to have?
Because the work is secondary analysis, a key requirement is access to well-characterized clinical trial samples and the corresponding trial data needed to relate omics patterns to clinical endpoints. The FOA gives examples of biospecimens such as blood, tissue, urine, or other biospecimens collected during the parent study.
Does the FOA emphasize generating new insight or repeating data collection?
The emphasis is on using existing samples and datasets to produce new insight. The FOA frames the work as leveraging archived materials and data to ask new mechanistic or responder/non-responder questions rather than repeating primary data collection.
What kinds of interventions are in scope?
The FOA targets complementary and alternative medicine (CAM) interventions and bioactive food component interventions, specifically in the context of analyzing variable responses observed in clinical trial settings.
Which NIH institutes or centers are associated with this opportunity?
The description notes the involvement of NCCAM (now known as NCCIH) and NCI. This signals interest in CAM-related interventions and bioactive food components, including those relevant to cancer prevention, causation, or supportive care contexts where such interventions are commonly studied.
What is the program category and CFDA numbers associated with the opportunity?
The opportunity is categorized as a discretionary grant and falls under health-related research and training programs. The CFDA numbers listed are 93.213 (Research and Training in Complementary and Integrative Health) and 93.393 (Cancer Cause and Prevention Research).
Who is eligible to apply?
Eligibility is broad. The listing includes domestic applicants across many organization types, including public and private institutions of higher education, nonprofit organizations (including 501(c)(3) organizations), state and local governments, tribal governments and tribal organizations, special district governments, independent school districts, public housing authorities/Indian housing authorities, and for-profit organizations (including small businesses and other for-profits).
Are foreign institutions eligible to apply?
Yes. The listing notes that foreign institutions are eligible to apply.
Can federal agencies apply?
Yes. The listing indicates that eligible federal agencies may apply.
Are faith-based or community-based organizations eligible?
Yes. The listing notes that faith-based or community-based organizations can apply, consistent with NIH's broad applicant pool when scientific and administrative requirements can be met.
Is cost sharing or matching required?
No. Cost sharing or matching is not required for this opportunity.
When was the FOA posted and is it still active?
The FOA was posted on June 6, 2007. It was archived on September 14, 2009, meaning it is not an active funding opportunity today.
Did the FOA have multiple application due dates?
Yes. The FOA had multiple receipt dates, meaning applications were accepted on more than one deadline (as specified in the full announcement).
Where was the full announcement hosted?
The full announcement was hosted on the NIH Grants Guide website. NIH also provided standard webmaster contacts for technical access issues.
What makes this FOA a useful reference even though it is archived?
Even though the FOA is archived, it serves as a reference for NIH-supported work that combines clinical trial datasets and archived biospecimens with omics-driven secondary analyses to understand variable responses to CAM and bioactive food component interventions.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 07 378) also looked into and applied for these:
| Funding Opportunity |
|---|
| Nutrition and Alcohol Related Health Outcomes (R01) Apply for PA 07 403 Funding Number: PA 07 403 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Nutrition and Alcohol Related Health Outcomes (R03) Apply for PA 07 404 Funding Number: PA 07 404 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Genetic Epidemiology of Substance Use Disorders(R01) Apply for PA 07 413 Funding Number: PA 07 413 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Genetic Epidemiology of Substance Use Disorders (R03) Apply for PA 07 414 Funding Number: PA 07 414 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Genetic Epidemiology of Substance Use Disorders(R21) Apply for PA 07 415 Funding Number: PA 07 415 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Health Promotion Among Racial and Ethnic Minority Males (R21) Apply for PA 07 421 Funding Number: PA 07 421 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Health Promotion Among Racial and Ethnic Minority Males (R01) Apply for PA 07 422 Funding Number: PA 07 422 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Research on Malignancies in the Context of HIV/AIDS (R21) Apply for PA 07 454 Funding Number: PA 07 454 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Research on Malignancies in the Context of HIV/AIDS (R01) Apply for PA 07 455 Funding Number: PA 07 455 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Continued Development and Maintenance of Software (R01) Apply for PAR 08 010 Funding Number: PAR 08 010 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Angiogenesis in the Nervous System in Health and Disease (R01) Apply for PA 08 015 Funding Number: PA 08 015 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Angiogenesis in the Nervous System in Health and Disease (R21) Apply for PA 08 016 Funding Number: PA 08 016 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Quick Trials for Novel Cancer Therapies and Prevention Exploratory Grants (R21) Apply for PAR 08 025 Funding Number: PAR 08 025 Agency: National Institutes of Health Category: Education Health Funding Amount: $250,000 |
| Research on Co Morbid Mental and Other Physical Disorders (R01) Apply for PA 08 029 Funding Number: PA 08 029 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Exfoliated Cells, Bioactive Food Components, and Cancer (R01) Apply for PA 08 030 Funding Number: PA 08 030 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Exfoliated Cells, Bioactive Food Components, and Cancer (R21) Apply for PA 08 031 Funding Number: PA 08 031 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Molecular Approaches to Diet and Pancreatic Cancer Prevention (R01) Apply for PA 08 032 Funding Number: PA 08 032 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Thyroid in Aging (R01) Apply for PA 08 037 Funding Number: PA 08 037 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Thyroid in Aging (R21) Apply for PA 08 038 Funding Number: PA 08 038 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Thyroid in Aging (R03) Apply for PA 08 039 Funding Number: PA 08 039 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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