Opportunity Information: Apply for PAR 14 239
Apply for PAR 14 239
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Oncology Models Forum (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research.
- This funding opportunity was created on Feb 20, 2015 and posted on May 30, 2014.
- Applicants must submit their applications by Feb 20, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses County governments Special district governments Small businesses State governments Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply.Non domestic (non U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Oncology Models Forum (U24) funding opportunity (PAR-14-239) is a National Institutes of Health (NIH), National Cancer Institute (NCI) cooperative agreement designed to create a centralized, community-facing resource for translational cancer researchers who rely on mouse models and human-in-mouse systems. The core problem the FOA is trying to solve is that, even though these models are widely used and increasingly important for preclinical and translational work, NCI-supported investigators lack a single, comprehensive place to find practical guidance and shared knowledge on how to generate new models, validate and credential them properly, understand when and how to use specific models, and keep pace with evolving modeling technologies. In addition, researchers need a clearer view of what model resources already exist, including catalogs of available models, programs, services, and related support infrastructure.
The funded project is expected to establish and maintain an "Oncology Models Forum" that functions as an ongoing hub for information sharing, standards and best practices, collaboration, and education around the effective and reliable use of mice, mouse models, and human-in-mouse models for translational cancer research. While the emphasis is on these model systems, the FOA also leaves room for the forum to address other mouse modeling needs as they are identified by the broader scientific community, meaning the scope is meant to be responsive and shaped by real-world user demand rather than locked to a narrow initial topic list.
A defining feature of this award is that the Forum is expected to be built on an online infrastructure using an existing platform called the NCIP Hub. The announcement highlights that NCIP Hub can support interactive, real-time collaboration and sharing of complex research assets, not just static documents. Examples given include shared mouse model datasets alongside human molecular and genomic datasets, plus analytical tools suited to cross-species comparisons. The FOA also specifically calls out imaging-intensive data types and workflows that are common in oncology modeling, such as radiology image files and pathology whole slide images, as well as software capabilities for image analysis and annotation. Beyond data and tools, the platform is also meant to host and deliver educational content, including training materials and videos, reinforcing that the Forum is not just a repository but also a training and community-building mechanism.
Because this is a cooperative agreement (U24), the relationship between the awardee and NCI is intended to be collaborative rather than hands-off. NCI explicitly states it will assist awardees in leveraging and enhancing the community-building, research collaboration, and education capabilities of the NCIP Hub. In practical terms, applicants should expect substantial programmatic involvement from NCI compared with a standard grant mechanism, with the shared goal of making the Forum broadly useful to NCI-supported investigators and the wider translational cancer research community.
From an administrative standpoint, this opportunity falls under discretionary funding and is categorized in the health and education activity areas, with relevance across multiple NCI CFDA listings (93.393 through 93.396) spanning cancer cause and prevention, detection and diagnosis, treatment, and cancer biology research. The award ceiling listed is $750,000, and there is no cost sharing or matching requirement, which means applicants are not required to provide non-federal matching funds as a condition of award.
Eligibility is broad and includes many U.S.-based public and private higher education institutions, nonprofits (with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations (including small businesses, excluding certain constraints that may be specified in the full FOA), and a range of governmental entities (city/township, county, state, special districts, and certain public housing authorities). The FOA also enumerates eligibility for several mission-relevant institution types and community-oriented organizations, including HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and AANAPISIS institutions, as well as faith-based and community-based organizations and eligible federal agencies. Foreign organizations and foreign institutions are stated as not eligible to apply as the applicant organization; however, foreign components, as defined under NIH policy, are allowed, and non-U.S. components of U.S. organizations may be eligible, which is an important nuance for teams with international collaborations or distributed operations.
Key dates in the posted record include an original posted date of May 30, 2014, with the record showing creation on February 20, 2015, and an archive date of March 20, 2015. The listing indicates an original closing date of May 1, 2015, and also shows February 20, 2015 as a "current closing date" in the source data, reflecting the way archived FOAs are sometimes represented in databases after the opportunity has closed. For full application instructions, required components, and cooperative agreement expectations, the FOA points to the NIH Grants Guide link: http://grants.nih.gov/grants/guide/pa-files/PAR-14-239.html.
FAQs: Oncology Models Forum (U24) - PAR-14-239
What is the Oncology Models Forum (U24) funding opportunity?
The Oncology Models Forum (U24), PAR-14-239, is an NIH National Cancer Institute (NCI) cooperative agreement intended to fund the creation and maintenance of a centralized, community-facing resource for translational cancer researchers who use mouse models and human-in-mouse systems.
What problem is this funding opportunity trying to solve?
The FOA targets a gap in shared, practical guidance for NCI-supported investigators who rely on mouse and human-in-mouse models. Even though these models are widely used, investigators lack a single, comprehensive place to find guidance on generating new models, validating and credentialing them, choosing appropriate models for specific research questions, keeping up with evolving technologies, and understanding what model resources (catalogs, programs, services, infrastructure) already exist.
What is the main goal of the funded project?
The funded project is expected to establish and maintain an ongoing "Oncology Models Forum" that serves as a hub for information sharing, standards and best practices, collaboration, and education related to the effective and reliable use of mice, mouse models, and human-in-mouse models in translational cancer research.
Is the Forum limited only to mouse models and human-in-mouse systems?
Mouse models and human-in-mouse systems are the emphasis, but the FOA leaves room for the Forum to address other mouse modeling needs as they are identified by the broader scientific community. In other words, the scope is intended to be responsive to community demand rather than fixed to a narrow initial list of topics.
What is the required platform or infrastructure for the Forum?
A defining feature is that the Forum is expected to be built on an online infrastructure using an existing platform called the NCIP Hub.
What kinds of capabilities does the NCIP Hub support, according to the FOA?
The FOA highlights that NCIP Hub can support interactive, real-time collaboration and sharing of complex research assets, not just static documents. Examples mentioned include sharing mouse model datasets alongside human molecular and genomic datasets, as well as analytical tools suited to cross-species comparisons.
Does the FOA emphasize any specific data types or workflows?
Yes. The FOA specifically calls out imaging-intensive data types and workflows common in oncology modeling, including radiology image files and pathology whole slide images, along with software capabilities for image analysis and annotation.
Is the Forum expected to provide training or educational content?
Yes. Beyond data and tools, the platform is also meant to host and deliver educational content, including training materials and videos. The FOA frames the Forum as more than a repository; it is also intended to support training and community-building.
What does it mean that this is a cooperative agreement (U24)?
Because this is a U24 cooperative agreement, the award is intended to involve a collaborative relationship between the awardee and NCI rather than a hands-off approach. Applicants should expect substantial programmatic involvement from NCI compared with a standard grant mechanism.
How will NCI be involved during the project?
NCI explicitly states it will assist awardees in leveraging and enhancing the community-building, research collaboration, and education capabilities of the NCIP Hub, with the shared goal of making the Forum broadly useful to NCI-supported investigators and the wider translational cancer research community.
What is the award ceiling for this opportunity?
The award ceiling listed in the opportunity record is $750,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal matching funds as a condition of award.
What funding categories or activity areas are associated with this opportunity?
The opportunity is described as discretionary funding and categorized in the health and education activity areas.
Which NCI/NIH CFDA listings are relevant?
The listing notes relevance across multiple NCI CFDA listings (93.393 through 93.396), spanning cancer cause and prevention, detection and diagnosis, treatment, and cancer biology research.
Who is eligible to apply?
Eligibility is broad and includes many U.S.-based public and private higher education institutions; nonprofits (with and without 501(c)(3) status, other than institutions of higher education); for-profit organizations (including small businesses, subject to any constraints in the full FOA); and a range of governmental entities (city/township, county, state, special districts, and certain public housing authorities).
Are minority-serving institutions and community-oriented organizations eligible?
Yes. The FOA enumerates eligibility for mission-relevant institution types and community-oriented organizations, including HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and AANAPISIS institutions, as well as faith-based and community-based organizations.
Are federal agencies eligible to apply?
Yes. The FOA indicates eligible federal agencies are included among eligible applicants.
Are foreign organizations eligible to apply as the applicant organization?
No. Foreign organizations and foreign institutions are stated as not eligible to apply as the applicant organization.
Are any international or foreign project elements allowed?
Yes, with important nuance. The FOA states that foreign components, as defined under NIH policy, are allowed, and non-U.S. components of U.S. organizations may be eligible. This may matter for teams with international collaborations or distributed operations, even though the applicant organization itself must be eligible and not a foreign institution.
What key dates are shown in the opportunity record?
The posted record shows an original posted date of May 30, 2014; creation on February 20, 2015; an archive date of March 20, 2015; and an original closing date of May 1, 2015. The record also shows February 20, 2015 as a "current closing date" in the source data, reflecting how archived FOAs can appear in databases after the opportunity has closed.
Where can applicants find the full FOA and official application instructions?
The FOA directs applicants to the NIH Grants Guide page for PAR-14-239 at http://grants.nih.gov/grants/guide/pa-files/PAR-14-239.html for full application instructions, required components, and cooperative agreement expectations.
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