Operations Research (Implementation Science) for Strengthening Program Implementation through the Presidents Emergency Plan for AIDS Relief (PEPFAR) | Apply Online

Opportunity Summary:

The grant opportunity titled "Operations Research (Implementation Science) for Strengthening Program Implementation through the Presidents Emergency Plan for AIDS Relief (PEPFAR)" is a CDC funding announcement designed to strengthen HIV/AIDS programs in PEPFAR-supported countries by funding practical, real-world research that improves how services are delivered. Rather than focusing on basic science or early-stage product development, the emphasis is on operations research and implementation science, meaning studies that look at what works in routine program settings, why it works (or does not), and how to improve uptake, quality, efficiency, and impact. The overall aim is to generate usable evidence that helps programs optimize HIV prevention, care, and treatment services, ultimately improving population-level outcomes in countries supported by PEPFAR.

This funding opportunity (Funding Opportunity Number RFA GH 11 005) was offered as a discretionary cooperative agreement under the health funding activity category. A cooperative agreement typically means the CDC expects to have substantial involvement in the project, such as collaboration on technical approaches, monitoring progress, and ensuring findings can be translated into program improvements. The announcement anticipated about 35 awards, with an estimated total funding amount of $20,000,000. Individual awards were expected to fall between $200,000 (award floor) and $500,000 (award ceiling). There was no cost-sharing or matching requirement, which reduces the burden on applicants and makes it more feasible for local institutions to participate without needing additional non-federal funds to meet a matching threshold.

A central feature of this FOA is its focus on supporting host country investigators and institutions, described as "PEPFAR Local Partners." Eligibility is limited to local partners in countries that have CDC Global AIDS Program (GAP) offices and CDC GAP-supported projects. In practice, this restriction signals an intentional approach to build in-country research leadership and strengthen local capacity to identify implementation challenges, test solutions, and apply findings directly within national or subnational HIV programs. The eligible applicant types are described generally as "others" with clarification provided in the eligibility section: public and nonprofit private institutions and agencies working in PEPFAR-supported countries, connected to CDC GAP presence and programming. This keeps the applicant pool tightly aligned with places where CDC and PEPFAR programming infrastructure exists and where results can be rapidly integrated into ongoing service delivery systems.

The program purpose is explicitly tied to strengthening implementation across the HIV service continuum: prevention, care, and treatment. The types of research supported under an implementation science framing commonly include studies that evaluate barriers to service access, strategies to improve linkage to care, retention and adherence interventions, models for task shifting and workforce optimization, approaches to improve the quality and timeliness of HIV testing and ART initiation, methods to strengthen supply chains and clinic workflows, and improvements in monitoring systems and data use for decision-making. While the FOA text provided does not list specific priority research questions, it is clear that CDC is seeking projects that address operational bottlenecks and help programs deliver higher-quality services at scale. The standard of success is not only publication or academic output, but concrete knowledge that can improve program performance and maximize the impact of PEPFAR investments on HIV outcomes at the population level.

Key administrative details show that this was a time-limited competition posted on February 10, 2011, created on April 21, 2011, and originally due April 11, 2011, with the closing date extended to April 29, 2011. The archive date is April 30, 2011, meaning the announcement is no longer active. The CFDA number associated with the opportunity is 93.067 (Global AIDS), confirming that the work sits within the U.S. government global HIV/AIDS assistance portfolio.

For applicants or institutions trying to locate the full requirements, the notice indicates that the complete announcement had to be accessed through the "Full Announcement" section of the posting rather than a direct external link. For technical issues obtaining the full announcement, the contact listed is the CDC Procurement and Grants Office (PGO), Technical Information Management Section (TIMS), at 770-488-2700. Overall, the opportunity can be understood as CDC support for locally led, program-embedded research in PEPFAR countries, with the practical objective of improving how HIV services are implemented so that prevention, care, and treatment programs achieve greater reach, quality, and measurable public health impact.

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