Opportunity Information: Apply for RFA GH 16 005

  • The HHS-CDC-HHSCDCERA in the health sector is offering a public funding opportunity titled "Operations Research (Implementation Science) for Strengthening Program Implementation through the Presidents Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
  • This funding opportunity was created on Jan 07, 2016 and posted on Jan 07, 2016.
  • Applicants must submit their applications by Mar 25, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $500,000.00 in funding.
  • The number of recipients for this funding is limited to 5 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for RFA GH 16 005

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Opportunity Summary:

The grant opportunity titled "Operations Research (Implementation Science) for Strengthening Program Implementation through the President's Emergency Plan for AIDS Relief (PEPFAR)" (Funding Opportunity Number RFA GH 16 005) is a U.S. government funding announcement released by the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (HHS-CDC). It is a discretionary funding opportunity offered through a cooperative agreement, which typically means the CDC expects to have substantial involvement during the project period, such as collaborating on technical direction, monitoring progress, and supporting implementation and evaluation activities rather than acting only as a passive funder.

The core focus of the opportunity is operations research, also commonly described as implementation science, aimed at improving how HIV/AIDS programs are delivered in countries supported by PEPFAR. Rather than funding basic biomedical discovery, the intent is to support practical, real-world research that identifies what works, what does not, and why, when HIV prevention, care, and treatment services are rolled out at scale. The emphasis is on generating actionable evidence that can strengthen program implementation in selected priority areas across the HIV service continuum, with the end goal of optimizing service delivery and increasing population-level impact in PEPFAR-supported settings. In plain terms, the projects are expected to produce knowledge that helps programs run more effectively, reach more people, and achieve better outcomes using the resources already being invested.

This funding announcement is positioned within the health funding activity category (CFDA 93.067) and is designed to directly support investigators based at public institutions and nonprofit private institutions and agencies operating in PEPFAR-supported countries. The opportunity also lists a broad range of eligible applicant types, including various levels of U.S. government entities (state, county, city/township, special district), independent school districts, public and state-controlled colleges and universities, private institutions of higher education, federally recognized tribal governments and other tribal organizations, public housing authorities/Indian housing authorities, and nonprofits both with and without 501(c)(3) status. The eligibility language suggests that while the work is meant to benefit and be conducted in PEPFAR-supported countries, applicants can come from multiple organizational categories, with additional clarification presumably provided in the full FOA text.

In terms of funding scale and competitiveness, the announced award ceiling is $500,000 per award, with an expected total of five awards. That combination signals a relatively targeted competition intended to fund a small set of projects that are likely to be high-priority, policy-relevant, and capable of producing results that can be used to improve PEPFAR program performance. The opportunity was created and posted on January 7, 2016, and had an application closing date of March 25, 2016 (no change between the original and current close date in the provided data), indicating it was a time-limited solicitation for that funding cycle.

Overall, the opportunity is best understood as a mechanism for the CDC, working under PEPFAR, to fund applied research partnerships that test and refine strategies for delivering HIV services more efficiently and effectively in real program contexts. The expected outcome is not just academic publication, but practical evidence that can be translated into better implementation decisions, improved service coverage and quality, and stronger HIV prevention, care, and treatment results at scale in PEPFAR-supported countries.

Frequently Asked Questions (FAQs)

What is the title of this grant opportunity?

The opportunity is titled "Operations Research (Implementation Science) for Strengthening Program Implementation through the President's Emergency Plan for AIDS Relief (PEPFAR)."

What is the Funding Opportunity Number (FOA number)?

The Funding Opportunity Number listed is RFA GH 16 005.

Which U.S. government agency is offering this funding?

This is a U.S. government funding announcement from the U.S. Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC).

What type of funding mechanism is being used?

The announcement describes the award as a cooperative agreement, which generally means CDC expects substantial involvement during the project period (for example, collaborating on technical direction, monitoring progress, and supporting implementation and evaluation activities), rather than acting only as a passive funder.

What is the main purpose of this funding opportunity?

The core purpose is to support operations research (implementation science) to improve how HIV/AIDS programs are delivered in countries supported by PEPFAR. The intent is to generate practical, real-world evidence that helps strengthen program implementation across the HIV service continuum.

Is this funding intended for basic biomedical research?

No. The focus is not basic biomedical discovery. The emphasis is on applied, real-world research that examines what works, what does not, and why, when HIV prevention, care, and treatment services are implemented at scale.

What kinds of results are projects expected to produce?

Projects are expected to produce actionable evidence that can be used to strengthen program implementation, optimize service delivery, and increase population-level impact in PEPFAR-supported settings. The expected outcome is practical evidence that can inform implementation decisions, improve service coverage and quality, and strengthen HIV prevention, care, and treatment results at scale.

How does the opportunity define or describe "operations research" in this context?

The announcement frames operations research as implementation science focused on improving program delivery in real service settings, with an emphasis on identifying and explaining implementation successes and challenges during rollout at scale.

What program or initiative is this opportunity associated with?

The opportunity is associated with the President's Emergency Plan for AIDS Relief (PEPFAR).

What is the CFDA number and funding activity category?

The opportunity is positioned within the health funding activity category and lists CFDA 93.067.

Who is this opportunity designed to support?

It is designed to directly support investigators based at public institutions and nonprofit private institutions and agencies operating in PEPFAR-supported countries.

What types of organizations are eligible to apply (as listed)?

The eligible applicant types listed include:

  • Various levels of U.S. government entities (state, county, city/township, special district)
  • Independent school districts
  • Public and state-controlled colleges and universities
  • Private institutions of higher education
  • Federally recognized tribal governments and other tribal organizations
  • Public housing authorities/Indian housing authorities
  • Nonprofits with 501(c)(3) status
  • Nonprofits without 501(c)(3) status

Does the eligibility language suggest any geographic or operating context?

Yes. The description indicates the work is meant to benefit and be conducted in PEPFAR-supported countries, and it references institutions and agencies operating in those settings, while also listing a broad range of eligible applicant organization types.

What is the maximum award amount (award ceiling)?

The announced award ceiling is $500,000 per award.

How many awards are expected?

The opportunity indicates an expected total of five awards.

What does the award ceiling and expected number of awards suggest about competitiveness?

With a $500,000 ceiling and an expected five awards, the opportunity appears relatively targeted, aiming to support a small set of high-priority, policy-relevant projects expected to produce usable results for improving PEPFAR program performance.

When was the opportunity posted?

The opportunity was created and posted on January 7, 2016.

What was the application closing date?

The application closing date listed is March 25, 2016.

Did the closing date change?

No change is indicated between the original and current close date in the provided information.

What does "strengthening program implementation" mean in practical terms for this opportunity?

Based on the description provided, it means producing knowledge and evidence that helps HIV programs run more effectively, reach more people, and achieve better outcomes using resources already being invested in PEPFAR-supported settings.

What parts of HIV programming are included in the scope?

The description references selected priority areas across the HIV service continuum, including HIV prevention, care, and treatment services when rolled out at scale.

Is CDC expected to participate during the project period?

Yes. Because the mechanism is a cooperative agreement, CDC is expected to have substantial involvement during the project period, such as collaborating on technical direction, monitoring progress, and supporting implementation and evaluation activities.

Is the opportunity focused on producing publications or program improvements?

The description emphasizes that the expected outcome is not just academic publication, but practical evidence that can be translated into better implementation decisions and improved HIV program outcomes at scale in PEPFAR-supported countries.

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