Opportunity Information: Apply for PA 13 058
Apply for PA 13 058
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Pain in Aging (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.866 Aging Research.
- This funding opportunity was created on Dec 20, 2012 and posted on Dec 20, 2012.
- Applicants must submit their applications by Jan 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public and State controlled institutions of higher education City or township governments Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Independent school districts State governments County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Pain in Aging (R01) funding opportunity (PA-13-058) is a National Institutes of Health (NIH) Research Project Grant announcement inviting applications that focus on pain specifically through an aging lens. The core idea is to support research that helps explain how pain develops, is experienced, is measured, and is treated in later life. Projects can center on older human populations, compare age groups to identify meaningful differences, or examine how pain-related biology and behavior change with age over time. The announcement is intentionally broad in scope, signaling interest in basic, translational, and clinical research that can improve understanding and care for pain in older adults.
A major emphasis of the FOA is on three priority areas. First, NIH is seeking studies that identify mechanisms and predictors of pain in aging. This can include uncovering why certain older adults experience more severe or persistent pain, what biological or psychosocial factors increase vulnerability, and how age-related changes in nervous system function, inflammation, or other physiological systems shape pain sensitivity and recovery. Second, it encourages the development and evaluation of pain assessment tools designed for older adults (or for older model organisms in preclinical research). This priority reflects real-world challenges in assessing pain in late life, such as sensory changes, cognitive impairment, communication barriers, atypical symptom presentation, or the need for measures validated in older cohorts rather than younger adults. Third, the FOA highlights research on pain management strategies for older adults, with specific attention to the complexity of treating pain in people with multiple chronic conditions. That focus includes the practical and safety challenges of polypharmacy, drug-disease interactions, functional limitations, and the need to balance pain relief with risks like falls, confusion, sedation, and reduced independence.
The opportunity explicitly welcomes a wide range of scientific approaches and outcomes. Studies may examine biological factors such as genetic, molecular, and neurobiological mechanisms, as well as clinical outcomes and behavioral, psychological, and social contributors to pain. This makes room for work spanning from bench science (for example, studying age-related changes in nociceptive pathways) to applied clinical and health services research (for example, evaluating tailored pain interventions in older patients with comorbidities). Both animal studies and human subjects research are considered appropriate, with the announcement calling particular attention to the value of animal models that use aged animals rather than only young adults, since aging itself may change pain mechanisms and treatment responses.
Administratively, this is an NIH discretionary grant opportunity using the R01 mechanism, meaning it supports investigator-initiated research projects that typically involve a well-developed, hypothesis-driven plan with clearly defined aims and a strong rationale. The funding opportunity was posted on December 20, 2012, and the original and final closing date listed is January 7, 2016, with an archive date of February 7, 2016, indicating it is no longer active as a current solicitation but remains accessible as a reference. The FOA lists multiple CFDA numbers associated with NIH programs that can intersect with pain and aging research, including Aging Research (93.866) and areas related to complementary and integrative health, alcohol research, and drug abuse and addiction research, reflecting the cross-cutting nature of pain science and its relevance to multiple NIH missions.
Eligibility is broad and includes a wide mix of applicant organizations. Eligible applicants include public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (other than small businesses, though small businesses are also listed separately), and various government entities such as state, county, city/township, special district governments, and independent school districts. The announcement also notes eligibility for tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and a range of institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISIs. It also allows non-U.S. (foreign) organizations and regional organizations, as well as U.S. territories or possessions, and includes faith-based or community-based organizations and eligible federal agencies. There is no cost sharing or matching requirement listed, which typically reduces barriers for applicants by not requiring institutional matching funds.
For reference and full administrative details, NIH provided an additional information link to the complete announcement on the NIH grants guide (PA-13-058). Contact support listed is the NIH Office of Extramural Research (OER) webmaster email for technical issues accessing or linking to the announcement, indicating that the provided contact is primarily for electronic access problems rather than scientific program guidance.
FAQs: Pain in Aging (R01) Funding Opportunity (PA-13-058)
What is the Pain in Aging (R01) funding opportunity (PA-13-058)?
PA-13-058 is a National Institutes of Health (NIH) Research Project Grant (R01) funding opportunity that invited research applications focused on pain specifically through an aging lens. It was designed to support studies that improve understanding of how pain develops, is experienced, is measured, and is treated in later life.
What is the main purpose or goal of this FOA?
The goal is to fund research that advances knowledge and care related to pain in older adults. The announcement is broad and supports basic, translational, and clinical research aimed at explaining pain processes in aging and improving assessment and management approaches for later life.
Is this opportunity still open for applications?
No. The FOA lists an original and final closing date of January 7, 2016, and an archive date of February 7, 2016. That indicates it is no longer active as a current solicitation, though it remains available as a reference in the NIH grants archive.
What grant mechanism does this opportunity use?
This opportunity uses the NIH R01 mechanism. An R01 generally supports investigator-initiated research projects with a well-developed, hypothesis-driven plan, clearly defined aims, and a strong scientific rationale.
What kinds of research topics does the FOA encourage?
The FOA encourages research that examines pain in later life, including how pain develops, how it is perceived and reported, how it can be measured accurately in older populations, and how it can be treated safely and effectively given the realities of aging and comorbidities.
What are the three main priority areas highlighted in the announcement?
The FOA emphasizes: (1) identifying mechanisms and predictors of pain in aging, (2) developing and evaluating pain assessment tools for older adults (or older model organisms), and (3) researching pain management strategies for older adults, including the complexity of treating pain alongside multiple chronic conditions.
What does “mechanisms and predictors of pain in aging” mean in this FOA?
It refers to studies that investigate why some older adults experience more severe or persistent pain and what factors increase vulnerability. This can include biological contributors (such as nervous system function and inflammation) and psychosocial contributors that influence pain sensitivity, persistence, and recovery in older age.
Does the FOA support research on biological mechanisms of pain in aging?
Yes. The opportunity explicitly welcomes studies examining genetic, molecular, and neurobiological mechanisms relevant to pain in aging, including research that tracks how pain-related biology changes with age over time.
Does the FOA support behavioral, psychological, and social research related to pain in older adults?
Yes. In addition to biological factors, the announcement welcomes studies focused on behavioral, psychological, and social contributors to pain and related clinical outcomes in older populations.
Are clinical studies and health services research approaches within scope?
Yes. The FOA is intentionally broad and allows work ranging from bench science to applied clinical and health services research, such as evaluating tailored pain interventions for older patients with comorbidities.
Are studies required to focus only on older adults?
No. Projects can center on older human populations, compare age groups to identify meaningful differences, or examine age-related changes over time. The key is that pain is studied through an aging lens.
Does the FOA allow research that compares different age groups?
Yes. The announcement states that studies may compare age groups to identify meaningful differences in pain experience, mechanisms, measurement, or treatment response.
Does the FOA encourage longitudinal or over-time research on how pain changes with age?
Yes. The FOA notes interest in examining how pain-related biology and behavior change with age over time, which supports approaches that consider aging as a dynamic process.
What does the FOA say about pain assessment tools for older adults?
A major priority is the development and evaluation of pain assessment tools designed for older adults (and, in preclinical work, for older model organisms). This reflects the challenges of assessing pain in late life and the need for measures validated in older cohorts.
Why does the FOA emphasize pain assessment challenges in later life?
The FOA highlights real-world barriers to accurate pain assessment in older adults, including sensory changes, cognitive impairment, communication barriers, atypical symptom presentation, and the need to validate measures in older cohorts rather than relying on tools built primarily on younger adult data.
What pain management issues in older adults are highlighted by the FOA?
The FOA highlights the complexity of managing pain in people with multiple chronic conditions. It calls attention to issues like polypharmacy, drug-disease interactions, functional limitations, and the need to balance pain relief with risks such as falls, confusion, sedation, and reduced independence.
Does the FOA mention safety and practical concerns related to treatment in older adults?
Yes. It specifically flags concerns such as polypharmacy and medication interactions, as well as clinical risks like falls, confusion, sedation, and impacts on independence when treating pain in older adults.
Are both human subjects research and animal studies allowed?
Yes. The announcement states that both animal studies and human subjects research are appropriate.
Does the FOA encourage use of aged animals in preclinical pain research?
Yes. The FOA calls particular attention to the value of animal models that use aged animals rather than only young adults, because aging itself may change pain mechanisms and treatment responses.
Is the FOA limited to basic science, or does it include translational and clinical research?
It includes all of these. The FOA signals interest in basic, translational, and clinical research, as long as the work advances understanding and care related to pain in older adults.
Who is eligible to apply?
Eligibility is broad and includes many organization types: public and private institutions of higher education; nonprofits (including 501(c)(3) and certain non-501(c)(3) entities); for-profit organizations (other than small businesses, though small businesses are also listed separately); and numerous government entities.
What types of government entities are eligible?
The FOA lists eligibility for state, county, city/township, special district governments, and independent school districts, among others.
Are tribal governments and tribal organizations eligible to apply?
Yes. The announcement includes tribal governments and tribal organizations as eligible applicants.
Are U.S. territories or possessions eligible?
Yes. The eligibility list includes U.S. territories or possessions.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The announcement allows non-U.S. (foreign) organizations and regional organizations.
Are minority-serving institutions included in the eligible applicant types?
Yes. The FOA lists multiple institution categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISIs.
Are faith-based or community-based organizations eligible?
Yes. The opportunity includes faith-based or community-based organizations among eligible applicants.
Are eligible federal agencies allowed to apply?
Yes. The eligibility list includes eligible federal agencies.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement, meaning applicants are not required to provide institutional matching funds for this opportunity.
What CFDA numbers are associated with this FOA?
The FOA lists multiple CFDA numbers connected to NIH programs that intersect with pain and aging research, including Aging Research (93.866), and other areas related to complementary and integrative health, alcohol research, and drug abuse and addiction research.
Why does the FOA list multiple CFDA numbers?
The listing reflects that pain science is cross-cutting and relevant to multiple NIH missions and program areas, including aging and other domains that intersect with pain research.
Where can someone find the full announcement and administrative details?
NIH provided a link to the complete announcement in the NIH grants guide under PA-13-058, which contains full administrative requirements and details.
What contact support is provided in the FOA?
The contact listed is the NIH Office of Extramural Research (OER) webmaster email for technical issues accessing or linking to the announcement. The provided contact is described as support for electronic access problems rather than scientific program guidance.
Does the provided contact serve as scientific guidance for project fit?
Based on the information provided, the listed contact is for technical issues (accessing or linking to the announcement) and is not described as a scientific or programmatic point of contact.
When was this FOA posted?
The FOA was posted on December 20, 2012.
What does it mean that the FOA is “broad in scope”?
It means the announcement welcomes a wide range of approaches and outcomes, spanning basic mechanisms, translational work, clinical studies, and research addressing measurement and management of pain in older adults.
What does it mean to study pain “through an aging lens”?
In the context of this FOA, it means designing the research around aging-related questions such as how pain processes, reporting, measurement validity, biological mechanisms, and treatment risks and benefits may differ in later life compared with younger populations.
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| Pain in Aging (R21) Apply for PA 13 059 Funding Number: PA 13 059 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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