Opportunity Information: Apply for RFA AI 10 003

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Partnerships for Biodefense (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.856 Microbiology and Infectious Diseases Research.
  • This funding opportunity was created on Feb 18, 2010 and posted on Feb 18, 2010.
  • Applicants must submit their applications by May 20, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $20,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $300,000.00 in funding.
  • Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) City or township governments For profit organizations other than small businesses Small businesses Special district governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) County governments State governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The Partnerships for Biodefense (R01) opportunity (Funding Opportunity Number RFA-AI-10-003) is a discretionary NIH grant competition run through the National Institute of Allergy and Infectious Diseases (NIAID). Its main goal is to move promising biodefense countermeasures forward at the preclinical stage. In practical terms, NIAID is looking for research projects that can advance a lead candidate vaccine, therapeutic, adjuvant, or diagnostic aimed at biodefense-relevant pathogens and threats that fall under NIAID Category A, B, or C priority agents. The emphasis on "preclinical development" signals that the work is expected to go beyond basic discovery and into the kinds of studies that make a candidate more ready for later-stage development, such as optimization, proof-of-concept testing, performance characterization, and other non-clinical steps that strengthen the package for eventual translation.

The funding mechanism is the NIH R01, which is the standard investigator-initiated research project grant format, but here it is being used under a targeted Funding Opportunity Announcement focused specifically on biodefense partnerships and product-oriented development. The activity category is Health, and it is associated with CFDA 93.856 (Microbiology and Infectious Diseases Research). There is no cost sharing or matching requirement, meaning applicants are not required to contribute a defined share of project costs as a condition of the award.

NIAID projected a total commitment of $20,000,000 in FY2011 for this FOA, with an anticipated fifteen to twenty awards. The listed award ceiling is $300,000. Taken together, these details suggest NIAID intended to support a portfolio of multiple projects rather than a small number of very large awards, and to distribute support across several biodefense-related approaches and agent targets. The funding is framed as supporting "lead candidates," so applicants would generally be expected to have already identified a plausible candidate or platform and be proposing a clear plan to de-risk it through targeted preclinical work.

Eligibility is broad and includes many types of organizations. Eligible applicants include public and private institutions of higher education; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and a range of governmental entities such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The eligibility list also explicitly includes a number of additional organizational categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), tribal governments and tribal organizations (including those other than federally recognized), faith-based or community-based organizations, U.S. territories or possessions, regional organizations, and non-U.S. entities (foreign organizations). It also notes eligible agencies of the federal government, indicating federal entities could participate consistent with NIH rules for such applicants.

Key dates for this competition show it was posted and created on February 18, 2010, with an original and current closing date of May 20, 2010, and an archive date of June 20, 2010. In other words, this was a time-limited solicitation with a defined submission window, and it is now archived as an older funding announcement. The primary public link for the full announcement was provided through the NIH Grants Guide (http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-10-003.html), and technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contacts listed in the notice.

Overall, this FOA was designed to accelerate biodefense preparedness by funding preclinical, translationally oriented R01 projects that advance tangible medical countermeasure candidates (vaccines, therapeutics, adjuvants, and diagnostics) targeting high-priority NIAID biodefense agents across Categories A, B, and C, with substantial total program funding and a plan to make multiple awards to build a diversified development pipeline.

Frequently Asked Questions (FAQs)

What is the name of this grant opportunity?

The opportunity is titled "Partnerships for Biodefense (R01)."

What is the Funding Opportunity Number (FOA number)?

The Funding Opportunity Number is RFA-AI-10-003.

Which federal agency is running this competition?

This is an NIH grant competition run through the National Institute of Allergy and Infectious Diseases (NIAID).

What is the main purpose of this FOA?

The main goal is to move promising biodefense countermeasures forward at the preclinical stage by funding research projects that advance a lead candidate toward later-stage development.

What kinds of products or countermeasures does NIAID want to support under this FOA?

NIAID is looking for projects that can advance a lead candidate vaccine, therapeutic, adjuvant, or diagnostic aimed at biodefense-relevant pathogens and threats.

What types of biodefense threats or agents are in scope?

The FOA targets biodefense-relevant pathogens and threats that fall under NIAID Category A, B, or C priority agents.

What does "preclinical development" mean in the context of this opportunity?

It signals that the work is expected to go beyond basic discovery and include non-clinical studies that make a lead candidate more ready for later-stage development. Examples listed or implied include optimization, proof-of-concept testing, performance characterization, and other non-clinical steps that strengthen the package for eventual translation.

Is this FOA meant for early discovery research or later-stage development?

Based on the stated emphasis, it is geared toward preclinical, translationally oriented work rather than basic discovery. The FOA is framed around advancing "lead candidates," which implies a plausible candidate or platform should already be identified.

What grant mechanism is used for this funding?

The funding mechanism is the NIH R01 (Research Project Grant), used here under a targeted Funding Opportunity Announcement focused on biodefense partnerships and product-oriented development.

What is the activity category for this opportunity?

The activity category is Health.

What is the CFDA number associated with this opportunity?

It is associated with CFDA 93.856 (Microbiology and Infectious Diseases Research).

Is cost sharing or matching required?

No. The opportunity states there is no cost sharing or matching requirement.

How much total funding did NIAID plan to commit, and in what fiscal year?

NIAID projected a total commitment of $20,000,000 in FY2011 for this FOA.

How many awards were anticipated?

The FOA anticipated fifteen to twenty awards.

What is the award ceiling listed for this opportunity?

The listed award ceiling is $300,000.

What does the combination of the total program commitment, number of awards, and award ceiling suggest?

Taken together, it suggests NIAID intended to fund a portfolio of multiple projects (rather than a small number of very large awards) and distribute support across several biodefense-related approaches and agent targets.

Who is eligible to apply?

Eligibility is broad and includes many organizational types, including public and private institutions of higher education; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and various governmental entities.

Which governmental entities are listed as eligible applicants?

The eligibility list includes state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.

Are minority-serving and tribal institutions included in the eligibility list?

Yes. The eligibility list explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs).

Are tribal governments and tribal organizations eligible?

Yes. The eligibility list includes tribal governments and tribal organizations, including those other than federally recognized.

Are faith-based or community-based organizations eligible?

Yes. The eligibility list explicitly includes faith-based or community-based organizations.

Are U.S. territories or regional organizations eligible?

Yes. The eligibility list includes U.S. territories or possessions and regional organizations.

Are non-U.S. (foreign) organizations eligible to apply?

Yes. The eligibility list explicitly includes non-U.S. entities (foreign organizations).

Can federal government agencies apply?

The eligibility list notes eligible agencies of the federal government, indicating that federal entities could participate consistent with NIH rules for such applicants.

When was this FOA posted and created?

It was posted and created on February 18, 2010.

What was the closing (application due) date for this FOA?

The original and current closing date listed is May 20, 2010.

Is this funding opportunity still open?

No. The FOA is described as time-limited with a defined submission window, and it has an archive date of June 20, 2010.

Where was the full announcement publicly posted?

The primary public link was provided through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-10-003.html

Where were applicants directed for technical access issues?

Technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contacts listed in the notice.

In plain terms, what kind of projects would likely be competitive under this FOA (based on the description provided)?

Projects that start with an identified lead candidate or platform (vaccine, therapeutic, adjuvant, or diagnostic) and present a clear, product-oriented preclinical plan to de-risk and advance it through activities such as optimization, proof-of-concept testing, and performance characterization for NIAID Category A, B, or C biodefense agents.

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