Partnerships for Complementary Alternative Medicine (CAM) Clinical Translational Research (PCCTR) (U19) | Apply Online

Opportunity Summary:

The Partnerships for Complementary and Alternative Medicine (CAM) Clinical Translational Research (PCCTR) (U19) funding opportunity (PAR 09-066) is an NIH cooperative agreement program created by the National Center for Complementary and Alternative Medicine (NCCAM) to strengthen the scientific foundation of clinical research in complementary and alternative medicine. The central aim is not simply to run isolated clinical trials, but to develop practical, reusable translational tools, approaches, and methodologies that make CAM clinical research more rigorous, reproducible, and informative. A key theme throughout the announcement is building lasting clinical research capacity and leadership within CAM institutions while also advancing the broader field of CAM research.

PCCTR is designed around partnerships, specifically pairing CAM institutions and practitioners with highly research-intensive conventional institutions. The idea is that CAM practitioners and CAM-facing institutions bring real-world clinical insight, access to widely used practices, and understanding of how interventions are delivered in practice, while research-intensive partners contribute advanced methodology, infrastructure, and experience in rigorous clinical investigation. By requiring this kind of collaboration, the program aims to produce work that neither partner could accomplish as effectively alone, and to make sure that research questions and methods are grounded both in clinical reality and in strong scientific design.

Applications are expected to be organized as a U19 cooperative agreement, which generally means NIH has a more substantial programmatic role compared with a standard research grant. The funded effort is structured as a “center-like” partnership with an administrative framework and a small set of integrated research projects. Each PCCTR must include at least two and no more than three research projects over the funding period, encouraging focus and coherence rather than a large collection of unrelated studies. The program places clear emphasis on synergy across projects, meaning applicants should show how the projects connect, share resources or methods, and jointly contribute to the overall goal of creating translational tools for CAM clinical research.

The types of outcomes NIH is seeking here are clinical research translational tools that can move the field forward in concrete ways. In practice, that can include improved research methods for studying complex CAM interventions, better measurement strategies, optimized trial designs, standardized protocols, validated outcomes or biomarkers where appropriate, and other methodological advances that enable more credible evaluation of CAM practices already used widely by the public. The opportunity also reflects an underlying concern that CAM research faces unique challenges (such as practitioner-dependent interventions, individualized treatment approaches, difficulties with blinding, and variability in dosing or delivery), and that targeted methodological development is needed to address those challenges rather than forcing CAM research into ill-fitting conventional models.

From an eligibility and administrative standpoint, the opportunity falls under the NIH health research category (CFDA 93.213, Research and Training in Complementary and Integrative Health) and allows applications from a broad range of organization types. Eligible applicants include public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations), small businesses, for-profit organizations other than small businesses, and Native American tribal governments and organizations (including federally recognized tribal governments). The listing indicates no cost-sharing or matching requirement. The funding announcement was originally posted December 30, 2008, with later administrative updates reflected in the record, and it ultimately closed October 19, 2011, with an archive date of November 19, 2011. The award ceiling is listed as 0, which typically signals that a fixed maximum was not specified in the summary record and applicants would need to consult the full FOA text for budget expectations, limits, and NIH guidance.

Overall, PAR 09-066 supports multi-project, tightly coordinated CAM clinical translational research partnerships intended to raise the quality and impact of clinical CAM studies. It is built to develop methods and tools that the field can reuse, while also cultivating stronger clinical research expertise and leadership at CAM institutions through meaningful collaboration with research-intensive partners. For full requirements, cooperative agreement details, and application instructions, the announcement points applicants to the NIH Grants Guide page for PAR 09-066 and provides NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues.

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