Opportunity Information: Apply for RFA AI 10 010
Apply for RFA AI 10 010
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Partnerships for Development of New Therapeutic Classes for Select Viral and Bacterial Pathogens (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on May 3, 2010 and posted on May 3, 2010.
- Applicants must submit their applications by Jul 8, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Special district governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) County governments Private institutions of higher education City or township governments Independent school districts Public and State controlled institutions of higher education Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Partnerships for Development of New Therapeutic Classes for Select Viral and Bacterial Pathogens (R01) funding opportunity (RFA-AI-10-010) was a discretionary NIH grant program run through the National Institute of Allergy and Infectious Diseases (NIAID). Its main goal was to move promising anti-infective ideas closer to real-world use by supporting preclinical development work on lead therapeutic candidates. The FOA focused on three specific, high-priority pathogens: Neisseria gonorrhoeae (the cause of gonorrhea, with growing drug resistance concerns), Hepatitis B virus (a major chronic viral infection with significant global disease burden), and Clostridium difficile (a serious cause of antibiotic-associated diarrhea and colitis, especially in healthcare settings). In practical terms, the program aimed to fund projects that would help create or advance new classes of therapeutics, meaning approaches that are meaningfully different from existing drugs and that could expand the pipeline beyond incremental tweaks to older agents.
The award mechanism was the NIH R01, which is the standard research project grant intended to support a defined, hypothesis-driven or milestone-driven research plan led by an investigator team. Here, the emphasis was clearly on translational, preclinical development activities rather than basic discovery alone. That typically implies work such as optimizing lead compounds or biologics, characterizing mechanism of action, demonstrating efficacy in relevant in vitro systems and animal models, assessing preliminary pharmacology and toxicology considerations, developing assays that can support candidate selection, and generating the kinds of data needed to justify later-stage development. The word "partnerships" in the title also signals that NIAID was encouraging collaborative structures that bring together complementary expertise, for example, academic labs working with industry partners, medicinal chemistry groups, pharmacology teams, or product-development specialists.
NIAID planned to commit about $6 million in total costs in fiscal year 2011 for this FOA, with an expectation of supporting roughly 6 to 10 awards. The opportunity listed an award ceiling of $300,000, indicating that budgets were expected to stay at or below that cap (as presented in the source listing). The program did not require cost sharing or matching funds, which is typical for many NIH research grants and reduces barriers for academic and nonprofit applicants while still allowing industry participation.
Eligibility was broad and included a wide range of organization types: public and private institutions of higher education; nonprofit organizations both with and without 501(c)(3) status; for-profit organizations (including small businesses and other for-profits); local and state governments; tribal governments and tribally controlled institutions; U.S. territories or possessions; and certain non-U.S. entities (foreign organizations) and regional organizations. The FOA also explicitly included categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations, reflecting NIH's general openness to diverse institutional applicants as long as the proposed work meets the scientific and programmatic goals.
Key administrative details reflect that this was a time-limited competition. The FOA was posted on May 3, 2010, with an original and current closing date of July 8, 2010, and it was archived on August 8, 2010. The Catalog of Federal Domestic Assistance (CFDA) number associated with the program was 93.856 (Microbiology and Infectious Diseases Research), aligning it with NIAID's infectious disease research portfolio. Applicants seeking the full official announcement were directed to the NIH Grants Guide link provided in the listing, and NIH Office of Extramural Research (OER) webmaster contact information was included for access or technical issues.
Overall, this opportunity was designed to accelerate the preclinical pipeline for urgently needed therapeutics targeting gonorrhea, hepatitis B, and C. difficile by funding R01-scale projects that could produce strong lead-candidate packages and de-risk future development steps.
FAQs: Partnerships for Development of New Therapeutic Classes for Select Viral and Bacterial Pathogens (R01) (RFA-AI-10-010)
What is this funding opportunity?
This was a discretionary NIH grant program titled "Partnerships for Development of New Therapeutic Classes for Select Viral and Bacterial Pathogens (R01)" under funding opportunity number RFA-AI-10-010, run through the National Institute of Allergy and Infectious Diseases (NIAID).
What was the main purpose of the program?
The main goal was to move promising anti-infective ideas closer to real-world use by supporting preclinical development work on lead therapeutic candidates, with an emphasis on advancing new therapeutic classes rather than incremental modifications of existing drugs.
Which pathogens were specifically targeted by this FOA?
The FOA focused on three high-priority pathogens: Neisseria gonorrhoeae (gonorrhea), Hepatitis B virus, and Clostridium difficile.
Why were these pathogens considered high priority?
Neisseria gonorrhoeae was highlighted due to growing drug resistance concerns; Hepatitis B virus due to major chronic infection and significant global disease burden; and Clostridium difficile due to its role in serious antibiotic-associated diarrhea and colitis, especially in healthcare settings.
What does "new therapeutic classes" mean in the context of this opportunity?
It referred to therapeutic approaches that are meaningfully different from existing drugs and that would expand the development pipeline beyond incremental tweaks to older agents.
What grant mechanism was used?
The award mechanism was the NIH R01, the standard research project grant intended to support a defined, investigator-led research plan.
What type of work was the FOA trying to support (basic research vs. translational work)?
The emphasis was on translational, preclinical development activities rather than basic discovery alone.
What are examples of the kinds of preclinical development activities this program supported?
Examples included optimizing lead compounds or biologics, characterizing mechanism of action, demonstrating efficacy in relevant in vitro systems and animal models, assessing preliminary pharmacology and toxicology considerations, developing assays to support candidate selection, and generating data to justify later-stage development.
Why does the title include the word "Partnerships"?
The program encouraged collaborative structures that combine complementary expertise, such as academic teams working with industry partners, medicinal chemistry groups, pharmacology teams, or product-development specialists.
How much total funding did NIAID plan to commit?
NIAID planned to commit about $6 million in total costs in fiscal year 2011 for this FOA.
How many awards were expected?
The program expected to support roughly 6 to 10 awards.
Was there an award ceiling or budget cap?
Yes. The opportunity listed an award ceiling of $300,000, indicating budgets were expected to stay at or below that cap (as presented in the source listing).
Did the program require cost sharing or matching funds?
No. The program did not require cost sharing or matching funds.
What types of organizations were eligible to apply?
Eligibility was broad and included public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (including small businesses); local and state governments; tribal governments and tribally controlled institutions; U.S. territories or possessions; and certain non-U.S. entities (foreign organizations) and regional organizations.
Were minority-serving institutions and community-based organizations included in the eligibility language?
Yes. The FOA explicitly included categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations.
Who was the sponsoring NIH institute?
The opportunity was run through the National Institute of Allergy and Infectious Diseases (NIAID).
What is the CFDA number associated with this opportunity?
The CFDA number was 93.856, titled "Microbiology and Infectious Diseases Research."
When was the FOA posted and when did it close?
The FOA was posted on May 3, 2010. The original and current closing date was July 8, 2010.
Is this opportunity still open?
No. It was a time-limited competition and was archived on August 8, 2010.
Where were applicants directed to find the full official announcement?
Applicants were directed to the NIH Grants Guide link provided in the listing to access the full official announcement.
Who was listed for help with access or technical issues?
NIH Office of Extramural Research (OER) webmaster contact information was included for access or technical issues.
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