Opportunity Information: Apply for PA 07 165

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Pathogenesis And Treatment Of Lymphedema And Lymphatic Diseases (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.396 Cancer Biology Research 93.837 Cardiovascular Diseases Research 93.839 Blood Diseases and Resources Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research.
  • This funding opportunity was created on Dec 5, 2008 and posted on Dec 14, 2006.
  • Applicants must submit their applications by Jan 7, 2010 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses State governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education County governments Special district governments Native American tribal organizations (other than Federally recognized tribal governments).
  • Foreign institutions are eligible to apply.
Apply for PA 07 165

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Opportunity Summary:

Pathogenesis And Treatment Of Lymphedema And Lymphatic Diseases (R01) is a National Institutes of Health funding opportunity (FOA number PA-07-165) that supports investigator-initiated research aimed at improving the scientific understanding of lymphatic biology and the causes and treatment of lymphedema and related lymphatic disorders. The announcement emphasizes that the lymphatic system is an understudied but essential part of human physiology, influencing the health and function of many body systems. Because of that broad impact, multiple NIH institutes and centers are participating, including NHLBI, NICHD, NIAMS, NCI, NINR, NIBIB, and NCCAM, reflecting interest that spans cardiovascular and blood-related research, cancer biology, musculoskeletal and skin disease, nursing research, biomedical imaging and engineering, and complementary and integrative health.

The core scientific focus is on identifying why lymphatic diseases occur and how they might be better treated. The FOA specifically calls for studies that uncover developmental, molecular, and cellular defects that lead to lymphedema, with attention to both primary lymphedema (typically linked to inherited or developmental abnormalities of the lymphatic system) and secondary lymphedema (often acquired, for example after cancer surgery, radiation, infection, or other injuries that disrupt lymphatic drainage). In practical terms, applicants are being encouraged to propose projects that can clarify disease mechanisms (pathogenesis) and translate that knowledge into improved therapeutic strategies, which could include novel interventions, improved disease models, better diagnostic or monitoring approaches, or other scientifically grounded treatment advances.

The funding mechanism is the NIH Research Project Grant (R01), meaning it is intended for discrete, hypothesis-driven research projects that can be led by an established investigative team and carried out over a multi-year period. The FOA does not set a single fixed award size or project length; instead, budgets and durations are expected to vary depending on what each proposed study requires. Similarly, NIH does not commit to a specific number of awards in the description provided. The total number of grants and total dollars awarded depend on the mix of applications received, their scientific quality, and the requested costs and timeframes.

From an eligibility standpoint, the opportunity is broadly open to many types of applicants. Eligible organizations include higher education institutions (public and private), nonprofit organizations (including 501(c)(3) entities as well as certain nonprofits without 501(c)(3) status), small businesses, for-profit organizations (including those that are not small businesses), and a wide range of government entities such as state, county, city or township governments, special district governments, independent school districts, public housing authorities, and federally recognized and other Native American tribal governments and organizations. Foreign institutions are also eligible to apply, which is notable because not all NIH opportunities allow foreign organizational applicants.

Administratively, it is categorized as a discretionary grant opportunity in the health and education domain and is linked to several CFDA program areas (including complementary and integrative health research, technological innovations to improve human health, cancer biology, cardiovascular and blood disease research, and arthritis/musculoskeletal/skin disease research). The opportunity was originally posted in December 2006, with multiple receipt dates for applications, and the announcement indicates a final closing window in early 2010 with an archive date in February 2010. While those dates reflect the historical lifecycle of this specific posting, the summary still captures what NIH was seeking to fund: rigorous R01 research projects that move the field of lymphatic biology forward and lead toward better prevention and treatment options for lymphedema and other lymphatic diseases.

For full details, the official announcement was hosted on the NIH grants site at http://grants.nih.gov/grants/guide/pa-files/PA-07-165.html, and NIH provided an Office of Extramural Research (OER) webmaster contact for access or linking issues (FBOWebmaster@OD.NIH.GOV).

FAQs: Pathogenesis And Treatment Of Lymphedema And Lymphatic Diseases (R01) (PA-07-165)

What is this funding opportunity?

This is a National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) titled Pathogenesis And Treatment Of Lymphedema And Lymphatic Diseases (R01), FOA number PA-07-165. It supports investigator-initiated research to improve scientific understanding of lymphatic biology and to advance the causes, prevention, monitoring, and treatment of lymphedema and related lymphatic disorders.

What type of grant mechanism does it use?

The FOA uses the NIH Research Project Grant (R01) mechanism. This mechanism is intended for discrete, hypothesis-driven research projects carried out by an investigative team over a multi-year period.

What is the main scientific goal of the FOA?

The main goal is to identify why lymphatic diseases occur (their pathogenesis) and how they can be better treated. The FOA emphasizes studies that uncover developmental, molecular, and cellular defects that lead to lymphedema and related lymphatic disorders, and encourages translating mechanistic understanding into improved therapeutic strategies.

Which diseases or conditions are the focus of this FOA?

The FOA focuses on lymphedema and other lymphatic diseases and disorders. It highlights both primary lymphedema and secondary lymphedema.

What is primary lymphedema in the context of this FOA?

Primary lymphedema is described as typically linked to inherited or developmental abnormalities of the lymphatic system.

What is secondary lymphedema in the context of this FOA?

Secondary lymphedema is described as acquired and may occur after events that disrupt lymphatic drainage, such as cancer surgery, radiation, infection, or other injuries.

What kinds of research projects does NIH encourage under this FOA?

Applicants are encouraged to propose projects that:

  • Clarify disease mechanisms (pathogenesis) by identifying developmental, molecular, or cellular defects.
  • Translate mechanistic insights into improved therapeutic strategies.
  • Support treatment advances through approaches such as novel interventions, improved disease models, and better diagnostic or monitoring approaches, or other scientifically grounded strategies.

Why does the FOA emphasize lymphatic biology?

The FOA states that the lymphatic system is understudied but essential to human physiology and influences the health and function of many body systems. Because of this broad impact, the FOA reflects interest across multiple areas of health and biomedical research.

Which NIH Institutes and Centers are participating?

Multiple NIH Institutes and Centers participate, including:

  • NHLBI
  • NICHD
  • NIAMS
  • NCI
  • NINR
  • NIBIB
  • NCCAM

This participation reflects cross-cutting interest spanning areas such as cardiovascular and blood-related research, cancer biology, musculoskeletal and skin disease, nursing research, biomedical imaging and engineering, and complementary and integrative health.

Is the award size fixed?

No. The FOA does not set a single fixed award size. Budgets are expected to vary depending on what each proposed study requires.

Is the project period (duration) fixed?

No. The FOA does not set a single fixed project length. Durations are expected to vary depending on the needs of the proposed project.

Does the FOA guarantee a certain number of awards?

No. The FOA does not commit to a specific number of awards in the description provided. The total number of grants and total dollars awarded depend on factors including the mix of applications received, scientific quality, requested costs, and requested timeframes.

Who is eligible to apply?

Eligibility is broad. Eligible applicants include many organization types, including higher education institutions, nonprofits, small businesses, for-profit organizations, government entities, and tribal governments and organizations. Foreign institutions are also eligible.

Are U.S. colleges and universities eligible?

Yes. Eligible applicants include higher education institutions, including public and private institutions.

Are nonprofit organizations eligible?

Yes. Eligible applicants include nonprofit organizations, including 501(c)(3) entities as well as certain nonprofits without 501(c)(3) status.

Are small businesses eligible?

Yes. Small businesses are included among the eligible applicants.

Are for-profit organizations eligible?

Yes. Eligible applicants include for-profit organizations, including those that are not small businesses.

Are government entities eligible?

Yes. Eligible government applicants include a wide range of entities such as state, county, city or township governments, special district governments, independent school districts, public housing authorities, and Native American tribal governments and organizations.

Are foreign organizations eligible to apply?

Yes. The FOA notes that foreign institutions are eligible to apply, which is notable because not all NIH opportunities allow foreign organizational applicants.

What category of opportunity is this?

It is categorized as a discretionary grant opportunity in the health and education domain.

Are there program areas (CFDA) associated with this FOA?

Yes. The opportunity is linked to several CFDA program areas, including (as described in the provided information):

  • Complementary and integrative health research
  • Technological innovations to improve human health
  • Cancer biology
  • Cardiovascular and blood disease research
  • Arthritis, musculoskeletal, and skin disease research

When was this FOA originally posted, and what is its historical timeline?

The FOA was originally posted in December 2006, had multiple application receipt dates, and indicated a final closing window in early 2010, with an archive date in February 2010.

Where can applicants find the official FOA text?

The official announcement was hosted on the NIH grants website at: http://grants.nih.gov/grants/guide/pa-files/PA-07-165.html

Who is listed as a contact for access or linking issues?

NIH provided an Office of Extramural Research (OER) webmaster contact for access or linking issues: FBOWebmaster@OD.NIH.GOV

What is NIH trying to achieve by funding projects under this FOA?

Based on the description provided, NIH is seeking to fund rigorous R01 research projects that advance the field of lymphatic biology and move toward better prevention and treatment options for lymphedema and other lymphatic diseases by improving understanding of underlying mechanisms and enabling scientifically grounded therapeutic advances.

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