Opportunity Information: Apply for PAR 11 083
Apply for PAR 11 083
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Pathophysiology and Clinical Studies of Osteonecrosis of the Jaw (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Dec 22, 2010 and posted on Dec 22, 2010.
- Applicants must submit their applications by Jan 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: City or township governments Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) State governments County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education Special district governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Small businesses Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The funding opportunity titled "Pathophysiology and Clinical Studies of Osteonecrosis of the Jaw (R21)" (Funding Opportunity Number PAR-11-083) is a discretionary grant program released by the National Institute of Dental and Craniofacial Research (NIDCR) within the National Institutes of Health (NIH). It uses the NIH Exploratory/Developmental Research Grant mechanism (R21), which is designed to support early-stage, innovative, or high-impact projects that can open new directions rather than requiring an extensive body of preliminary data. The overall purpose of this announcement is to stimulate research that clarifies what drives osteonecrosis of the jaw (ONJ), how and why it develops in certain patients, and what evidence-based approaches might prevent or treat it.
The scientific focus is explicitly clinical and translational in nature, centering on four main goals. First, it seeks studies on the underlying pathophysiology of ONJ, meaning investigations into the biological mechanisms that lead to bone tissue death in the jaw, the local oral environment and microbial factors that may contribute, and systemic influences that affect bone remodeling, vascular supply, inflammation, and wound healing. Second, the announcement emphasizes identifying risk factors, which can include medication exposures, comorbid diseases, dental procedures, demographic and genetic factors, and treatment histories that increase the likelihood of ONJ. Third, it calls for work that establishes the natural history of the disease, supporting efforts to characterize how ONJ begins, progresses, and resolves (or fails to resolve) over time, including staging, clinical trajectories, and outcomes that matter to patients and clinicians. Fourth, it encourages generation of evidence for treatment, supporting the collection of data that can inform clinical decision-making, guide best practices, and strengthen the evidence base around therapeutic strategies.
Administratively, this opportunity falls under the Health funding activity category and is associated with CFDA number 93.121 (Oral Diseases and Disorders Research). The award ceiling is listed as 200,000, and there is no cost sharing or matching requirement. The program was posted and created on December 22, 2010, with an original and current closing date of January 7, 2014, and an archive date of February 7, 2014, indicating the opportunity is historical rather than currently open for applications.
Eligibility is broad and includes a wide range of organizations. Eligible applicants listed include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with or without 501(c)(3) status (excluding higher education institutions in those nonprofit categories as specified); for-profit organizations other than small businesses; and small businesses. It also includes Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments), as well as public housing authorities/Indian housing authorities. Additional eligible applicants noted include Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and non-U.S. entities (foreign organizations), reflecting NIH's willingness to consider a wide range of institutional settings capable of conducting relevant research.
For applicants looking for the full official announcement and detailed requirements, NIH provided an additional information link to the FOA on the NIH grants website: http://grants.nih.gov/grants/guide/pa-files/PAR-11-083.html. For technical issues accessing or linking to the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
FAQs: Pathophysiology and Clinical Studies of Osteonecrosis of the Jaw (R21) - PAR-11-083
What is the title and funding opportunity number for this grant?
The opportunity is titled "Pathophysiology and Clinical Studies of Osteonecrosis of the Jaw (R21)" and the Funding Opportunity Number (FOA) is PAR-11-083.
Which agency and institute released this opportunity?
This is a National Institutes of Health (NIH) discretionary grant opportunity released by the National Institute of Dental and Craniofacial Research (NIDCR).
What grant mechanism does this opportunity use?
The program uses the NIH Exploratory/Developmental Research Grant mechanism (R21).
What is the intent of the R21 mechanism in this announcement?
The R21 mechanism is intended to support early-stage, innovative, or potentially high-impact projects that can open new research directions, rather than requiring an extensive body of preliminary data.
What is the overall purpose of this funding opportunity?
The purpose is to stimulate research that clarifies what drives osteonecrosis of the jaw (ONJ), how and why it develops in certain patients, and what evidence-based approaches might prevent or treat it.
What type of research does this FOA emphasize?
The scientific focus is explicitly clinical and translational, concentrating on human-relevant mechanisms, patient risk, disease course, and evidence that can inform clinical practice.
What are the main scientific goals highlighted in the announcement?
The FOA centers on four goals: (1) understanding underlying pathophysiology, (2) identifying risk factors, (3) establishing the natural history of ONJ, and (4) generating evidence for treatment to strengthen clinical decision-making.
What does the FOA mean by studying the pathophysiology of ONJ?
Pathophysiology studies include investigations of biological mechanisms that lead to bone tissue death in the jaw, including local oral environment and microbial factors, as well as systemic influences affecting bone remodeling, vascular supply, inflammation, and wound healing.
What kinds of risk factors does the FOA call out?
Examples of risk factors include medication exposures, comorbid diseases, dental procedures, demographic and genetic factors, and treatment histories that may increase the likelihood of ONJ.
What does "natural history" mean in the context of this FOA?
Natural history refers to characterizing how ONJ begins, progresses, and resolves (or fails to resolve) over time, including staging, clinical trajectories, and outcomes that matter to patients and clinicians.
What does the FOA mean by generating evidence for treatment?
It encourages collecting data that can inform clinical decision-making, guide best practices, and strengthen the evidence base for therapeutic strategies used to prevent or treat ONJ.
What funding activity category is associated with this opportunity?
The funding activity category is Health.
What CFDA number is associated with this program?
The opportunity is associated with CFDA 93.121, "Oral Diseases and Disorders Research."
What is the award ceiling listed for this opportunity?
The award ceiling is listed as 200,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
When was this opportunity posted and created?
It was posted and created on December 22, 2010.
What were the closing dates for applications?
The original and current closing date listed is January 7, 2014.
Is this opportunity currently open?
No. The archive date is February 7, 2014, which indicates the opportunity is historical rather than currently open for applications.
Who is eligible to apply?
Eligibility is broad and includes many organization types such as governments (state, county, city or township, special district), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (with or without 501(c)(3) status, excluding higher education institutions in those nonprofit categories as specified), for-profit organizations other than small businesses, and small businesses.
Are tribal governments and tribal organizations eligible?
Yes. Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments) are included as eligible applicants.
Are public housing authorities eligible to apply?
Yes. Public housing authorities and Indian housing authorities are listed as eligible.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The eligible applicants list includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly included as eligible applicants.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are listed as eligible applicants.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included in the eligibility list.
Are regional organizations eligible?
Yes. Regional organizations are listed among eligible applicants.
Can non-U.S. (foreign) organizations apply?
Yes. Non-U.S. entities (foreign organizations) are listed as eligible.
Where can applicants find the official FOA with full details and requirements?
The official announcement is available on the NIH grants website at: http://grants.nih.gov/grants/guide/pa-files/PAR-11-083.html.
Who should be contacted for technical issues accessing or linking to the announcement?
Technical issues can be directed to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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