Opportunity Information: Apply for PA 06 501

The National Institute of Dental and Craniofacial Research, along with other institutes, is offering an Exploratory/Developmental (R21) grant opportunity focused on the pathophysiology of osteonecrosis of the jaw (ONJ), which is linked to bisphosphonate use. Researchers are encouraged to propose projects that explore the biological mechanisms behind impaired bone healing leading to ONJ. This funding opportunity aligns with two other grant mechanisms, R01 and R03, that address similar scientific topics. Funding is dependent on available resources and the quality of applications received.

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Pathophysiology of Bisphosphonates associated Osteonecrosis of the Jaw (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.395 Cancer Treatment Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research.
  • This funding opportunity was created on Dec 5, 2008 and posted on Jul 31, 2006.
  • Applicants must submit their applications by Sep 7, 2009 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2025.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: State governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) County governments Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Special district governments Small businesses.
  • Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply. Applicants may submit more than one application, provided each application is scientifically distinct. Projects must focus on studying oral bone homeostasis, healing response or repair capacity in the presence or absence of bisphosphonates rather than on the broad effects of bisphosphonates on bone quality. Projects that examine the effects of bisphosphonates on skeletal biology will not be considered unless the experimental design includes analysis of oral bones. Projects may study the effects of bisphosphonates on other physiological processes such as angiogenesis but only within the context that perturbation of these processes may compromise oral bone homeostasis and healing. Projects that examine the pharmacology of bisphosphonates will be considered non responsive unless the projects propose to test whether genetic variations alter the pharmacokinetics or pharmacodynamics of bisphosphonates. Epidemiological studies are non responsive.
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