Opportunity Information: Apply for RFA RM 08 025
Apply for RFA RM 08 025
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Patient Reported Outcomes Measurement Information System (PROMIS) Statistical Center (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Dec 4, 2008 and posted on Dec 4, 2008.
- Applicants must submit their applications by Mar 3, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $600,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Special district governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Small businesses County governments City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign Institutions are not eligible to apply as the primary applicant but they may enter into collaborations with a domestic institution that is the primary applicant.
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Opportunity Summary:
The Patient Reported Outcomes Measurement Information System (PROMIS) Statistical Center (PSC) (U54) funding opportunity (RFA-RM-08-025) is a National Institutes of Health initiative to create a dedicated statistical and psychometric coordinating center within the broader PROMIS Network. PROMIS is designed to serve as a shared national resource for the clinical research community by improving how patient-reported outcomes (PROs) are measured and used in clinical studies. In practical terms, this grant supports a central hub that helps ensure PROMIS measures are scientifically strong, comparable across studies, and easier for researchers to use when evaluating patient experiences like symptoms, functioning, and quality of life.
The core purpose of the PSC is to provide advanced statistical, psychometric, and data-coordination leadership for PROMIS. The center is expected to conduct collaborative research specifically focused on the statistical and measurement science challenges that come with PROs, such as item response theory modeling, calibration, validation, scoring, reliability, and cross-population comparability. Alongside that research mission, the PSC is responsible for coordinating data collection coming in from PROMIS Research Sites (PRS), monitoring and managing data quality, and helping organize general population sampling used to test and expand PROMIS item banks. The PSC is also expected to provide ongoing network-wide psychometric and statistical support so that the PROMIS sites and collaborators have consistent methods, documentation, and analytic guidance when developing or refining PROMIS domains.
Another major deliverable built into the announcement is support for translations. The PSC is tasked with developing PROMIS-approved translations for both new and existing domains, which signals an emphasis on making PROMIS tools usable across languages and populations while maintaining measurement equivalence. That typically implies attention to translation methodology, cultural adaptation, and statistical testing for differential item functioning and other forms of bias that can appear when instruments are used in different linguistic or cultural contexts.
This opportunity uses the U54 Research Center Cooperative Agreement mechanism, meaning the funded center would not operate as a standalone grantee working independently, but as a partner in a cooperative, NIH-guided program. Cooperative agreements generally involve substantial NIH programmatic involvement, and this announcement makes clear that the awardee will be joining an organized network of existing and new centers working collaboratively to advance technologies and methods for PROs in clinical research. The FOA also notes it runs in parallel with other related PROMIS funding announcements (two other U54s and one U01), indicating the PSC is one coordinated piece of a larger, multi-award program structure.
In terms of funding and scale, NIH anticipated a single award, with total funding for new awards under this initiative estimated at about $600,000 in total costs per year, and an expected award in FY2009. The opportunity was posted December 4, 2008, with an original and current closing date of March 3, 2009, and an archive date of April 3, 2009.
Eligibility is broad across U.S.-based organizations, reflecting the infrastructure and coordinating nature of the work. Eligible applicants include public and private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses), and multiple levels of government entities (state, county, city/township, special districts), as well as tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and independent school districts. The announcement also explicitly includes several categories of institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, U.S. territories or possessions, and eligible federal agencies. Foreign institutions are not eligible to apply as the primary applicant, but they may participate through collaborations with a U.S. domestic primary applicant. There is no cost sharing or matching requirement stated for this FOA.
Overall, the grant is aimed at building and operating the statistical, psychometric, and data-coordination backbone of PROMIS. The funded PSC would be expected to make PROMIS research sites more effective by standardizing data practices, strengthening measurement science, supporting large-scale sampling for item bank work, and expanding the accessibility of PROMIS through approved translations, all while functioning as an active collaborative partner within the NIH PROMIS Network.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is the Patient Reported Outcomes Measurement Information System (PROMIS) Statistical Center (PSC) (U54) funding opportunity under RFA-RM-08-025. It is an NIH initiative to create a dedicated statistical, psychometric, and data-coordination center within the broader PROMIS Network.
What is PROMIS and why does it matter for clinical research?
PROMIS is designed to serve as a shared national resource for the clinical research community by improving how patient-reported outcomes (PROs) are measured and used in clinical studies. In practical terms, it supports better, more comparable ways to evaluate patient experiences such as symptoms, functioning, and quality of life.
What is the PROMIS Statistical Center (PSC)?
The PSC is a central hub that provides advanced statistical and psychometric leadership and coordinates data-related activities across the PROMIS Network. Its role is to help ensure PROMIS measures are scientifically strong, comparable across studies, and easier for researchers to use.
What are the main goals of the PSC under this FOA?
The core purpose is to provide advanced statistical, psychometric, and data-coordination leadership for PROMIS. This includes collaborative research on measurement challenges for PROs, network-wide support to ensure consistent methods and guidance, and operational responsibilities related to data collection and quality.
What types of scientific and technical work is the PSC expected to perform?
The PSC is expected to conduct collaborative research focused on statistical and measurement science challenges related to PROs, including item response theory modeling, calibration, validation, scoring, reliability, and cross-population comparability.
Does the PSC coordinate data coming from other PROMIS sites?
Yes. A central responsibility of the PSC is coordinating data collection from PROMIS Research Sites (PRS), along with monitoring and managing data quality to support network-wide consistency.
What is the PSC role in general population sampling?
The PSC is expected to help organize general population sampling used to test and expand PROMIS item banks. This supports the development and refinement of PROMIS measures as broadly useful tools.
What kind of support does the PSC provide to PROMIS Research Sites and collaborators?
The PSC is expected to provide ongoing network-wide psychometric and statistical support so PROMIS sites and collaborators can rely on consistent methods, documentation, and analytic guidance when developing or refining PROMIS domains.
Are translations part of the required deliverables?
Yes. A major deliverable described in the announcement is support for translations. The PSC is tasked with developing PROMIS-approved translations for both new and existing domains.
Why does the FOA emphasize PROMIS-approved translations?
The emphasis signals a focus on making PROMIS tools usable across languages and populations while maintaining measurement equivalence. The description also implies attention to translation methodology, cultural adaptation, and statistical testing approaches that can identify bias when instruments are used across linguistic or cultural contexts.
What award mechanism is used for this opportunity?
This opportunity uses the U54 Research Center Cooperative Agreement mechanism.
What does a U54 cooperative agreement imply for how the center operates?
A cooperative agreement indicates the funded center would function as a partner in an NIH-guided program rather than operating independently as a standalone grantee. The FOA indicates substantial NIH programmatic involvement and emphasizes collaborative operation within an organized network.
Is this grant part of a larger PROMIS program structure?
Yes. The FOA notes it runs in parallel with other related PROMIS funding announcements (two other U54s and one U01), indicating the PSC is one coordinated component of a larger multi-award program.
How many awards did NIH anticipate making?
NIH anticipated a single award for this initiative.
What is the expected funding level for the PSC?
Total funding for new awards under this initiative was estimated at about $600,000 in total costs per year.
When was the expected award year?
The expected award was in FY2009.
When was the opportunity posted and when did it close?
The opportunity was posted on December 4, 2008. The original and current closing date was March 3, 2009. The archive date was April 3, 2009.
Who is eligible to apply?
Eligibility is broad for U.S.-based organizations. Eligible applicants include public and private institutions of higher education; nonprofits (501(c)(3) and non-501(c)(3)); for-profit organizations (including small businesses); state, county, city/township, and special district governments; tribal governments and tribal organizations; public housing authorities/Indian housing authorities; and independent school districts. The FOA also explicitly includes HBCUs, Hispanic-serving institutions, TCCUs, Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, U.S. territories or possessions, and eligible federal agencies.
Are foreign institutions eligible to apply as the primary applicant?
No. Foreign institutions are not eligible to apply as the primary applicant for this FOA.
Can foreign organizations participate in the project in any way?
Yes. Foreign institutions may participate through collaborations with a U.S. domestic primary applicant.
Is cost sharing or matching required?
No cost sharing or matching requirement is stated for this FOA.
What is a PROMIS Research Site (PRS) in the context of this FOA?
In the context provided, PROMIS Research Sites (PRS) are the sites generating and submitting data to the PROMIS Network. The PSC is responsible for coordinating incoming data from these sites and supporting them with statistical and psychometric guidance.
What is the overall purpose of funding the PSC?
The overall purpose is to build and operate the statistical, psychometric, and data-coordination backbone of PROMIS. The PSC is intended to make PROMIS research sites more effective by standardizing data practices, strengthening measurement science, supporting large-scale sampling for item bank work, and expanding accessibility through approved translations, while operating as a collaborative partner within the NIH PROMIS Network.
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