Paul Calabresi Career Development Award for Clinical Oncology (K12) | Apply Online

Opportunity Summary:

The Paul Calabresi Career Development Award for Clinical Oncology (K12), listed as Funding Opportunity Number PAR-10-155, is a National Cancer Institute (NCI) program designed to help institutions build structured, mentored career development pipelines for people who will lead cancer therapeutic clinical trials. The focus is on translational and patient-oriented research, especially the kind that moves discoveries from the lab and early concepts into real-world testing in humans through carefully designed, hypothesis-driven clinical trials. Rather than funding a single trainee directly, this opportunity funds an institutional program (a K12) that then supports multiple scholars under a common training and mentoring framework.

At its core, the program aims to increase the number of investigators who can design, launch, and run cancer therapeutic clinical trials across the full spectrum of early and later stage testing, including pilot studies and Phase I, Phase II, and Phase III trials. It is intended for clinicians such as M.D.s, D.O.s, and Pharm.D.s, and it can also include Ph.D.-level basic research scientists (or equivalents) when the institution proposes a dual-track model. In a single-track program, the K12 supports clinician career development only. In a dual-track program, both clinicians and Ph.D. scientists are developed in parallel, with a strong expectation that they will work together in team-based research environments. The idea is to speed translation by ensuring that clinicians and scientists interact closely and collaborate in ways that directly advance patient-oriented therapeutic studies.

A key boundary of this FOA is what it does not support. While it values basic science as a driver of translation, the award is not meant to train laboratory-based researchers whose work will be primarily centered on animal models or other non-human model systems without a clear and direct link to patient-oriented therapeutic cancer research and clinical trials. In other words, the training emphasis is on investigators who will be active participants and leaders in human therapeutic trials and the translational steps needed to make those trials possible.

The mechanism used is the NIH Institutional Research Career Development Award (K12). This means the applicant organization develops the program structure, mentorship approach, scholar selection process, and research career development experiences, and then appoints scholars to the program under the award. An important administrative feature noted in the announcement is that K12 programs are institutional and may not be transferred from one institution to another. The FOA also notes that awards are renewable, which signals that successful programs may be continued through competitive renewals, depending on NIH policies and review outcomes.

Funding levels and the number of awards are not specified as fixed amounts in the summary text. Instead, NCI indicates that the total amount awarded and the number of awards will depend on the number of applications submitted, their quality, the proposed project durations, and the requested budgets. This is typical of many NIH program announcements where the institute retains flexibility and makes decisions based on peer review and program priorities.

Eligibility is broad and includes many types of organizations that can host an institutional career development program. Eligible applicants include public and private institutions of higher education, public or state-controlled institutions of higher education, certain nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities outside of higher education), and for-profit organizations other than small businesses. The eligibility listing also highlights multiple categories of mission-focused and historically underrepresented-serving institutions, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and U.S. territories or possessions. The opportunity does not require cost sharing or matching.

From an administrative standpoint, the opportunity is categorized as a discretionary grant with activity categories spanning education and health, and it is associated with CFDA numbers 93.395 (Cancer Treatment Research) and 93.398 (Cancer Research Manpower). The opportunity was posted and created on March 26, 2010, with dates indicating the announcement period and archival timing as listed in the source details. A full announcement link is provided through the NIH Grants Guide, and technical access questions are directed to the NIH Office of Extramural Research (OER) webmaster contacts included in the notice.

In practical terms, an institution applying to PAR-10-155 would be proposing a comprehensive clinical oncology career development program that identifies promising early-career clinician investigators (and optionally Ph.D. scientists), pairs them with strong mentorship, and gives them the protected time, resources, and structured training needed to become independent, trial-capable translational researchers. The expected outcome is a stronger workforce of investigators who can turn scientific ideas into well-run therapeutic cancer trials and, ultimately, improved patient care options.

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