Paul Calabresi Career Development Award for Clinical Oncology (K12) | Apply Online

Opportunity Summary:

The Paul Calabresi Career Development Award for Clinical Oncology (K12) is a National Institutes of Health (NIH) funding opportunity that supports institutional career development programs focused on building the next generation of clinical trials researchers in oncology and related clinical therapeutic research areas. Rather than funding a single individual, this K12 mechanism is designed to help an eligible organization create and run a structured training and mentored career development program that recruits, supports, and develops multiple early-career scholars over time. The overall intent is to strengthen the national pipeline of investigators who can design, implement, and evaluate clinical therapeutic research protocols in real-world clinical trial environments.

At its core, the program targets the training of professionals who will lead or substantially contribute to clinical trials across the spectrum of trial phases, including pilot and Phase I studies (often emphasizing safety, dosing, and feasibility), Phase II trials (typically focused on preliminary efficacy and further safety), and Phase III trials (larger, comparative studies that can change standards of care). The emphasis is on clinical therapeutic research, meaning the award is geared toward preparing investigators to test interventions and treatments in patients through well-designed clinical research protocols, not just observational studies. The aim is practical and workforce-oriented: increasing the number of highly trained clinical trials researchers who can move promising therapies through rigorous testing and ultimately improve patient outcomes.

The FOA specifically highlights a broad range of potential scholar backgrounds, reflecting how multidisciplinary clinical trials work has become. It is intended to support clinicians such as M.D.s and D.O.s, Pharm.D.s involved in therapeutic development and evaluation, and nurses who hold Ph.D.s or equivalent research doctorates, alongside non-clinician postdoctoral researchers whose work is directly relevant to clinical therapeutic trials. In other words, the program is not limited to physicians; it recognizes that modern clinical trials require expertise spanning clinical care, pharmacology, nursing science, biostatistics, trial operations, ethics, regulatory compliance, and translational research, and it encourages institutional programs that can nurture talent across those domains.

Administrative details in the source indicate this is a discretionary grant opportunity offered by HHS/NIH (listed as HHS-NIH11) under the Funding Opportunity Number PAR-16-189. The activity sits in the education and health category and is associated with CFDA numbers 93.398 (and also lists 93.398 again in the data provided). The opportunity was posted on April 14, 2016, with an original and current closing date shown as June 15, 2018. While the listing does not provide an award ceiling, expected award counts, or other budget figures in the fields shown, the key takeaway is that institutions apply to establish or maintain a formal K12 program that provides mentored career development support to multiple trainees.

Eligibility is intentionally broad and includes many types of organizations that can plausibly host a high-quality clinical trials training environment. Eligible applicants include public and private institutions of higher education; state, county, city, township, and special district governments; independent school districts; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education where specified); for-profit organizations other than small businesses; and small businesses, with a note that “Others” may be eligible depending on the additional eligibility text in the full announcement. This breadth suggests NIH’s interest in enabling a variety of research ecosystems to build capacity, so long as they can credibly provide the mentoring, clinical trial infrastructure, and research environment needed for scholars to develop into independent clinical trials investigators.

In practical terms, a competitive application under this FOA would be expected to describe a coherent institutional program for career development in clinical trials research: how scholars will be selected, what structured training they will receive (for example, trial design, biostatistics, regulatory requirements, ethics, data safety monitoring, recruitment and retention, and protocol development), how mentoring teams will be organized, and how the institution will ensure scholars gain hands-on experience in designing and conducting clinical therapeutic trials. The spirit of the program is to turn promising early-career researchers into investigators who can not only participate in trials, but also originate strong clinical questions, build feasible and ethical protocols, manage trial conduct, analyze outcomes, and ultimately compete successfully for independent research funding in clinical oncology and therapeutic research.

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