Opportunity Information: Apply for RFA HL 15 012
Apply for RFA HL 15 012
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Pediatric Cardiac Genomics Consortium (UM1)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jul 8, 2014 and posted on Jul 8, 2014.
- Applicants must submit their applications by Oct 15, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,300,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $269,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Independent school districts Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) State governments County governments Private institutions of higher education Special district governments Native American tribal governments (Federally recognized) For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign Institutions Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Pediatric Cardiac Genomics Consortium (PCGC) (UM1) funding opportunity (RFA-HL-15-012) was a National Institutes of Health (NIH) cooperative agreement designed to support a small number of multi-center Research Centers that would work together as part of the PCGC. The overall goal of the consortium is to discover genetic causes of human congenital heart disease (CHD) and to connect specific genetic variants found in children with CHD to clinical features and longer-term outcomes. In practice, this means building and studying well-characterized patient cohorts, generating and analyzing genomic data, and integrating genetics with detailed clinical information so the field can better understand why CHD occurs and how genetic differences influence disease severity, treatment response, and prognosis.
A key feature of this opportunity is that it sits inside a broader collaborative structure called the Bench to Bassinet (B2B) Program. Under B2B, the PCGC is intended to operate in close coordination with the basic-science Cardiovascular Development Consortium (CvDC) and with the Pediatric Heart Network (PHN), which is oriented toward clinical research in pediatric cardiology. The design encourages a translational pipeline where genetic discoveries and mechanistic insights from developmental biology can inform clinically meaningful studies, and where clinical observations and outcomes data can guide genetic analyses and experimental follow-up. The announcement explicitly encourages sites that were not already members of the PCGC to apply, with an emphasis on proposing new scientific directions or capabilities that would strengthen and expand the consortium.
Mechanistically, the award uses the UM1 activity code, meaning it is a cooperative agreement rather than a traditional investigator-initiated grant. That signals substantial NIH programmatic involvement and coordination, reflecting the expectation of active collaboration across funded sites, shared protocols or harmonized approaches where appropriate, and participation in consortium-wide studies and governance. The opportunity was positioned within NIH program areas tied to cardiovascular disease research and child health and human development, consistent with the focus on pediatric congenital heart disease and genomics.
In terms of scale and timing, the FOA anticipated making about five awards, with an estimated total funding amount of approximately $2.3 million and an award ceiling listed at $269,000. It did not require cost sharing or matching. The announcement was posted July 8, 2014, with an original and current closing date of October 15, 2014, and it was archived November 15, 2014, indicating it was a time-limited competition rather than an open-ended, continuously available program.
Eligibility was broad and included many types of U.S.-based organizations and governmental entities, such as public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations other than small businesses (with small businesses also eligible), and various levels of government (state, county, city or township, special district). The eligible applicant list also encompassed tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and a range of mission-serving institutions, including HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities, and Asian American and Native American Pacific Islander-serving institutions. Foreign institutions and other non-U.S. entities were not eligible to apply, and non-U.S. components of U.S. organizations were not eligible; however, foreign components as defined by the NIH Grants Policy Statement were allowed, which typically means limited, well-justified international elements can be included under NIH rules even when the prime applicant must be domestic.
Overall, this opportunity funded collaborative centers focused on pediatric CHD genomics, with a strong emphasis on consortium science, shared infrastructure and data-driven discovery, and linking genetic findings to clinical outcomes in a way that bridges basic developmental biology and clinical pediatric cardiology through the Bench to Bassinet Program. For full details, NIH directed applicants to the official FOA webpage (http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-15-012.html) and provided NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues.
Frequently Asked Questions (FAQs)
What is the Pediatric Cardiac Genomics Consortium (PCGC) UM1 funding opportunity?
This opportunity (RFA-HL-15-012) was an NIH cooperative agreement (UM1) intended to fund a small number of multi-center Research Centers that would work together as part of the Pediatric Cardiac Genomics Consortium (PCGC).
What is the main goal of the PCGC?
The overall goal is to discover genetic causes of human congenital heart disease (CHD) and to link specific genetic variants found in children with CHD to clinical features and longer-term outcomes.
What kinds of activities and research approaches does the PCGC emphasize?
The description emphasizes building and studying well-characterized patient cohorts, generating and analyzing genomic data, and integrating genomic findings with detailed clinical information to better understand why CHD occurs and how genetic differences relate to disease severity, treatment response, and prognosis.
How does this opportunity fit into the Bench to Bassinet (B2B) Program?
The PCGC is part of a broader collaborative structure called the Bench to Bassinet (B2B) Program. Under B2B, the PCGC is intended to coordinate closely with the Cardiovascular Development Consortium (CvDC) and the Pediatric Heart Network (PHN).
What are the CvDC and PHN, and why do they matter for PCGC applicants?
Within the B2B structure, the CvDC is oriented toward basic-science cardiovascular development, while the PHN is oriented toward clinical research in pediatric cardiology. The design encourages a translational pipeline where genetic discoveries and developmental biology insights can inform clinically meaningful studies, and clinical observations and outcomes data can guide genetic analyses and follow-up work.
Are organizations that are not already part of the PCGC encouraged to apply?
Yes. The announcement explicitly encouraged sites that were not already members of the PCGC to apply, with an emphasis on proposing new scientific directions or capabilities that would strengthen and expand the consortium.
What does it mean that this award uses the UM1 activity code?
UM1 is a cooperative agreement mechanism rather than a traditional investigator-initiated grant. As described, that signals substantial NIH programmatic involvement and coordination and reflects expectations of active collaboration across funded sites, participation in consortium-wide studies and governance, and shared protocols or harmonized approaches where appropriate.
How many awards were expected under this FOA?
The FOA anticipated making about five awards.
What was the estimated total funding amount for this competition?
The estimated total funding amount was approximately $2.3 million.
What was the listed award ceiling?
The award ceiling was listed at $269,000.
Was cost sharing or matching required?
No. The FOA did not require cost sharing or matching.
When was the opportunity posted, and what was the application deadline?
The announcement was posted on July 8, 2014. The original and current closing date was October 15, 2014.
Is this funding opportunity still open?
No. The FOA was archived on November 15, 2014, indicating it was a time-limited competition rather than an open-ended program.
What types of organizations were eligible to apply?
Eligibility was broad for U.S.-based organizations and governmental entities, including public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses), and various levels of government (state, county, city or township, and special district).
Are tribal governments and tribal organizations eligible?
Yes. The eligible applicant list included tribal governments and tribal organizations.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities were included as eligible applicants.
Are mission-serving institutions (such as HBCUs and Hispanic-serving institutions) eligible?
Yes. The eligible applicant list included HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities, and Asian American and Native American Pacific Islander-serving institutions.
Are foreign institutions allowed to apply as the primary applicant?
No. Foreign institutions and other non-U.S. entities were not eligible to apply as the prime applicant.
Are non-U.S. components of U.S. organizations eligible?
No. Non-U.S. components of U.S. organizations were not eligible, as described in the opportunity summary.
Are any international elements allowed at all?
Yes, limited international involvement was possible: foreign components (as defined by the NIH Grants Policy Statement) were allowed, meaning well-justified international elements could be included under NIH rules even though the prime applicant had to be domestic.
What NIH program areas does this opportunity relate to?
The opportunity was positioned within NIH program areas tied to cardiovascular disease research and child health and human development, consistent with the pediatric congenital heart disease and genomics focus.
What is the intended impact of linking genetic variants to clinical features and outcomes?
The intent is to help the field understand why CHD occurs and how genetic differences influence disease severity, treatment response, and prognosis by integrating genomic data with detailed clinical information and longer-term outcome data.
Where can applicants find the official FOA details?
NIH directed applicants to the official FOA webpage: http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-15-012.html
Who was listed for help with access or linking issues?
The opportunity summary notes that NIH provided NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues.
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