Opportunity Information: Apply for RFA AI 15 057
Apply for RFA AI 15 057
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Pediatric Diagnostic Biomarkers for Active Pulmonary TB Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855, 93.856,.
- This funding opportunity was created on Nov 24, 2015 and posted on Nov 24, 2015.
- Applicants must submit their applications by Mar 11, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
This funding opportunity, titled "Pediatric Diagnostic Biomarkers for Active Pulmonary TB Disease (R01)" (Funding Opportunity Number RFA AI 15-057), is a discretionary grant announcement from the U.S. Department of Health and Human Services, National Institutes of Health (NIH) under the health funding activity category. It supports research projects that aim to discover, evaluate, and/or validate biomarkers or combinations of biomarkers that can improve the diagnosis of active pulmonary tuberculosis (TB) in children. A central emphasis is placed on pediatric populations where diagnosis is especially difficult, including children living with HIV infection, who often have atypical disease presentations and for whom existing diagnostic approaches may perform poorly.
The scientific focus of the announcement is on moving pediatric TB diagnostics beyond current limitations by identifying biological signals that reliably distinguish active pulmonary TB disease from other conditions. In practice, this could include host-derived markers (such as immune or inflammatory signatures), pathogen-derived markers (such as components of Mycobacterium tuberculosis detectable in clinical specimens), or multi-marker panels that improve diagnostic accuracy when used together. The FOA is framed around improving diagnostic capability rather than treatment development, with the underlying goal of enabling earlier and more accurate identification of active pulmonary TB in children, a group in which microbiologic confirmation can be challenging due to lower bacterial loads and difficulties obtaining sputum.
The award mechanism is an NIH R01 research project grant, meaning applicants are expected to propose a well-developed, hypothesis-driven or milestone-driven research plan with clear aims, appropriate study design, and a pathway toward meaningful biomarker validation. While the provided excerpt does not list an award ceiling or the expected number of awards, it clearly establishes the intended use of funds: supporting rigorous research that yields candidate biomarkers with practical diagnostic value, particularly for pediatric and HIV-affected pediatric cases.
Eligibility for this FOA is broad and includes multiple types of domestic entities that commonly participate in NIH research funding. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofit organizations with 501(c)(3) status (excluding higher education institutions) and nonprofits without 501(c)(3) status (excluding higher education institutions); for-profit organizations other than small businesses; and small businesses. The listing also includes an "Others" category with a note to consult additional eligibility information in the full announcement for any clarifications or special conditions.
Key administrative details from the source data show that the announcement was created and posted on November 24, 2015, with an original and current closing date of March 11, 2016. The associated CFDA numbers are 93.855 and 93.856, and the sponsoring agency is listed as HHS-NIH11. Overall, the opportunity is aimed at strengthening the evidence base and practical toolkit for diagnosing pediatric pulmonary TB by funding projects that can generate and validate biomarker-based approaches that perform better than current diagnostic options, especially in children with HIV co-infection.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The funding opportunity is titled "Pediatric Diagnostic Biomarkers for Active Pulmonary TB Disease (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA AI 15-057.
Which federal agency is offering this grant?
This is a discretionary grant announcement from the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH). The sponsoring agency is listed as HHS-NIH11.
What type of grant mechanism is used?
The award mechanism is an NIH R01 research project grant. This generally implies a well-developed research plan with clear aims and an appropriate study design geared toward producing meaningful research outcomes, including biomarker evaluation and validation.
What is the main purpose of this opportunity?
The purpose is to support research projects that discover, evaluate, and/or validate biomarkers (or combinations of biomarkers) to improve the diagnosis of active pulmonary tuberculosis (TB) in children.
What specific TB condition is the FOA focused on?
The FOA is focused on improving diagnosis of active pulmonary TB disease in pediatric populations.
Why does this FOA emphasize pediatric TB diagnosis?
The announcement emphasizes children because diagnosing active pulmonary TB in children is often difficult. Challenges include lower bacterial loads and practical difficulties in obtaining sputum, which can make microbiologic confirmation harder than in adults.
Does the FOA prioritize any particular pediatric sub-populations?
Yes. A central emphasis is placed on pediatric populations where diagnosis is especially difficult, including children living with HIV infection. These children may have atypical disease presentations and existing diagnostic approaches may perform poorly for them.
What kinds of biomarkers are responsive to this FOA?
The FOA highlights several possible biomarker directions, including host-derived markers (for example, immune or inflammatory signatures), pathogen-derived markers (for example, components of Mycobacterium tuberculosis detectable in clinical specimens), and multi-marker panels that improve diagnostic accuracy when used together.
Is the goal to develop TB treatments?
No. The FOA is framed around improving diagnostic capability rather than treatment development. The underlying goal is earlier and more accurate identification of active pulmonary TB in children.
What is meant by improving diagnostics "beyond current limitations"?
As described, the scientific focus is on identifying biological signals that reliably distinguish active pulmonary TB disease from other conditions, aiming for better performance than existing approaches, especially in children and in children with HIV co-infection.
What stage of research is this grant intended to support?
Based on the description, the grant supports rigorous research that yields candidate biomarkers with practical diagnostic value, with an emphasis on discovery, evaluation, and/or validation and a pathway toward meaningful biomarker validation.
What is the funding activity category?
The funding activity category is health.
Who is eligible to apply?
Eligibility is broad and includes many domestic entity types, such as government entities, educational institutions, tribal entities and organizations, nonprofits, for-profits (other than small businesses), and small businesses.
Which government entities are eligible?
Eligible government applicants include state governments; county governments; city or township governments; special district governments; independent school districts; and public housing authorities/Indian housing authorities.
Are colleges and universities eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are tribal entities eligible?
Yes. The eligibility list includes federally recognized Native American tribal governments and Native American tribal organizations that are not federally recognized tribal governments.
Are nonprofit organizations eligible?
Yes. Eligible applicants include nonprofit organizations with 501(c)(3) status (excluding higher education institutions) and nonprofits without 501(c)(3) status (excluding higher education institutions).
Are for-profit organizations eligible?
Yes. The eligibility list includes for-profit organizations other than small businesses, and it separately includes small businesses as eligible applicants.
What does the "Others" eligibility category mean?
The listing includes an "Others" category with a note to consult additional eligibility information in the full announcement for clarifications or special conditions.
When was this FOA posted?
The announcement was created and posted on November 24, 2015.
What is the application closing date?
The original and current closing date listed is March 11, 2016.
Are the award ceiling or the number of awards specified?
No. The provided information does not list an award ceiling or the expected number of awards.
What are the CFDA numbers associated with this opportunity?
The associated CFDA numbers are 93.855 and 93.856.
What outcome is this FOA ultimately trying to enable?
The FOA aims to strengthen the evidence base and practical toolkit for diagnosing pediatric pulmonary TB by funding projects that can generate and validate biomarker-based approaches that perform better than current diagnostic options, particularly for children with HIV co-infection.
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