Opportunity Information: Apply for RFA HD 15 027
Apply for RFA HD 15 027
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Pediatric HIV/AIDS Cohort Study (PHACS) Coordinating Center (CC) (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Oct 23, 2014 and posted on Oct 23, 2014.
- Applicants must submit their applications by Jan 2, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,100,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,100,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: For profit organizations other than small businesses Private institutions of higher education Independent school districts Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Native American tribal governments (Federally recognized) County governments Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The Pediatric HIV/AIDS Cohort Study (PHACS) Coordinating Center (CC) (U01) opportunity (Funding Opportunity Number RFA-HD-15-027) is a National Institutes of Health (NIH) cooperative agreement designed to support the central infrastructure that keeps the PHACS research program running in a coordinated, scientifically rigorous way. The main goal of the announcement is to continue progress on two long-running, high-impact research priorities in pediatric HIV: first, understanding the clinical course and outcomes of adolescents who acquired HIV perinatally (meaning transmission around the time of birth), and second, clarifying the oral and broader systemic health effects in children who were exposed to antiretroviral (ARV) medications in utero and during infancy but may not themselves be HIV-infected. In practical terms, the FOA is about sustaining representative U.S. cohorts of children and adolescents and ensuring the program can answer these questions with consistent methods, high-quality data, and coordinated scientific direction across multiple disciplines.
A key feature of this FOA is that it funds a Coordinating Center rather than individual clinical sites. The Coordinating Center is expected to provide the operational backbone for PHACS, including maintaining and supporting the Scientific Leadership Group (SLG). The SLG is not just an advisory panel; it is meant to drive scientific decision-making and ensure that the cohort studies, protocols, and substudies are developed and implemented effectively. The FOA specifies that the CC must maintain the SLG through performance-based subcontracts, which signals that the Coordinating Center will be responsible for managing subcontracted activities, monitoring deliverables, and ensuring that leadership functions are met to agreed standards. The SLG is also expected to continue operating through scientific specialty working groups, reflecting the interdisciplinary nature of pediatric HIV research. Those working groups typically span clinical medicine, epidemiology, biostatistics, oral health, pharmacology/toxicology, adolescent health and development, mental health and neurodevelopment, and other areas needed to execute complex cohort protocols and ancillary studies.
Because the funding instrument is a U01 cooperative agreement, the award structure implies substantial NIH involvement compared to a standard grant. A cooperative agreement usually means NIH program staff will have an active role in oversight, coordination, and collaboration on milestones and overall direction, rather than simply providing funds and receiving periodic reports. The activity category is listed under Health, Income Security, and Social Services, and the CFDA number associated with this opportunity is 93.865 (Child Health and Human Development Extramural Research), aligning it with NICHD-related extramural research support within NIH.
The announcement anticipated making a single award (Expected Awards: 1), meaning the intent was to select one Coordinating Center to serve as the hub for the entire PHACS network. The estimated total funding and award ceiling were both listed as $1,100,000, and there is no cost-sharing or matching requirement. The opportunity was posted on October 23, 2014, with an original and current closing date of January 2, 2015, and an archive date of February 2, 2015, indicating this is a past, time-limited competition rather than an open, recurring solicitation.
Eligibility is broad across U.S.-based organizational types, spanning public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), for-profit entities (including small businesses), and various government entities (state, county, city/township, special district). It also explicitly includes a range of mission-driven institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions, as well as faith-based and community-based organizations and eligible federal agencies. At the same time, the FOA clearly restricts foreign participation: non-U.S. entities (foreign organizations and foreign institutions) are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components as defined by the NIH Grants Policy Statement are not allowed.
Overall, this FOA is best understood as an infrastructure and leadership award meant to keep a major national pediatric HIV cohort enterprise cohesive and productive. Rather than focusing on a single narrow hypothesis, it supports the coordination, governance, and interdisciplinary scientific working structure needed to run multiple protocols and substudies that track long-term outcomes for adolescents living with perinatally acquired HIV and for children exposed early in life to antiretroviral therapies. For reference, the full announcement was available through the NIH Grants Guide page linked in the opportunity record (http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-15-027.html), and the NIH Office of Extramural Research webmaster contact was provided for access or linking issues.
Frequently Asked Questions (FAQs): PHACS Coordinating Center (U01) - RFA-HD-15-027
What is this funding opportunity?
This opportunity is the Pediatric HIV/AIDS Cohort Study (PHACS) Coordinating Center (CC) (U01) funding announcement, Funding Opportunity Number RFA-HD-15-027. It is a National Institutes of Health (NIH) cooperative agreement intended to support the central coordinating infrastructure for the PHACS research program.
What is the main purpose of the PHACS Coordinating Center award?
The award is designed to sustain the central operations, coordination, and scientific leadership needed to keep the PHACS program running in a consistent, rigorous, and coordinated way across multiple disciplines and activities. It emphasizes infrastructure and governance rather than funding individual clinical sites.
What are the core research priorities this FOA aims to advance?
The announcement focuses on continuing progress in two major pediatric HIV research priorities:
- Understanding the clinical course and outcomes of adolescents who acquired HIV perinatally (transmission around the time of birth).
- Clarifying oral health and broader systemic health effects in children exposed to antiretroviral (ARV) medications in utero and during infancy, including children who may not be HIV-infected.
Does this FOA fund individual clinical sites or a central hub?
It funds a central Coordinating Center, not individual clinical sites. The Coordinating Center is intended to act as the operational backbone and coordinating hub for the PHACS network.
What is the funding mechanism and what does "U01 cooperative agreement" imply?
The mechanism is a U01 cooperative agreement. Compared with a standard grant, a cooperative agreement typically indicates substantial NIH involvement in oversight, coordination, and collaboration related to milestones and overall program direction.
What are the key responsibilities of the Coordinating Center under this FOA?
Based on the description provided, the Coordinating Center is expected to provide the central infrastructure for PHACS and to maintain and support the Scientific Leadership Group (SLG). This includes managing subcontracted activities tied to SLG functions, monitoring deliverables, and ensuring leadership activities meet agreed performance standards.
What is the Scientific Leadership Group (SLG) and what role does it play?
The SLG is described as a group that drives scientific decision-making for PHACS. It is not framed as only an advisory body; it is expected to guide scientific direction and ensure cohort studies, protocols, and substudies are developed and implemented effectively.
How is the SLG expected to be supported and maintained?
The FOA specifies that the Coordinating Center must maintain the SLG through performance-based subcontracts. This signals an expectation that the Coordinating Center will manage subcontracted leadership activities and track performance and deliverables.
Are scientific working groups part of the PHACS structure supported by this FOA?
Yes. The SLG is expected to continue operating through scientific specialty working groups, reflecting the interdisciplinary nature of the PHACS program.
What kinds of disciplines are referenced for the working groups?
The working groups typically span multiple specialties, including clinical medicine, epidemiology, biostatistics, oral health, pharmacology/toxicology, adolescent health and development, mental health and neurodevelopment, and other areas needed to carry out complex cohort protocols and related substudies.
What types of populations and cohorts does PHACS emphasize in this announcement?
The FOA is about sustaining representative U.S. cohorts of children and adolescents to support long-term research on adolescents living with perinatally acquired HIV and on children exposed to ARV medications early in life (in utero and during infancy), including those who may not be HIV-infected.
How many awards were expected to be made?
The announcement anticipated a single award (Expected Awards: 1), meaning one Coordinating Center was intended to serve as the hub for the PHACS network.
What is the estimated funding level for this opportunity?
The estimated total funding and the award ceiling were both listed as $1,100,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost-sharing or matching requirement.
When was this opportunity posted and what were the key dates?
The opportunity was posted on October 23, 2014. The original and current closing date was January 2, 2015, and the archive date was February 2, 2015.
Is this an open opportunity right now?
No. The listed closing and archive dates indicate this was a past, time-limited competition rather than an open solicitation.
What is the CFDA number associated with this opportunity?
The CFDA number associated with this opportunity is 93.865, identified as Child Health and Human Development Extramural Research.
What activity category is associated with this announcement?
The activity category is listed as Health, Income Security, and Social Services.
What organizations were eligible to apply?
Eligibility is broad across U.S.-based organizations, including public and private institutions of higher education, nonprofits (with and without 501(c)(3) status), for-profit entities (including small businesses), and government entities such as state, county, city/township, and special district governments. The eligibility description also explicitly includes mission-driven institutional categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, Asian American Native American Pacific Islander-serving institutions, as well as faith-based and community-based organizations and eligible federal agencies.
Are foreign (non-U.S.) organizations eligible to apply?
No. Non-U.S. entities (foreign organizations and foreign institutions) are not eligible to apply.
Can a U.S. organization include non-U.S. components in its application?
No. The FOA states that non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by the NIH Grants Policy Statement) are not allowed.
What does this FOA fund in practical terms?
In practical terms, it funds the infrastructure, coordination, governance, and interdisciplinary scientific leadership needed to support multiple cohort protocols and substudies. The emphasis is on consistent methods, high-quality data, and coordinated scientific direction across the program.
Where could applicants find the full announcement?
The full announcement was available via the NIH Grants Guide page at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-15-027.html
Who was listed as a contact for access or linking issues?
The NIH Office of Extramural Research webmaster contact was provided for access or linking issues related to the announcement page.
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