Opportunity Information: Apply for RFA HD 15 029
Apply for RFA HD 15 029
- The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "Pediatric HIV/AIDS Cohort Study (PHACS) Data and Operations Center (DOC) (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.173 Research Related to Deafness and Communication Disorders 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Oct 23, 2014 and posted on Oct 23, 2014.
- Applicants must submit their applications by Jan 2, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $17,975,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $17,975,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments Private institutions of higher education Independent school districts Public housing authorities/Indian housing authorities Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The Pediatric HIV/AIDS Cohort Study (PHACS) Data and Operations Center (DOC) (U01) funding opportunity (RFA-HD-15-029) is a National Institutes of Health (NIH) cooperative agreement meant to continue support for PHACS, a long-running U.S. research effort focused on understanding pediatric and adolescent outcomes related to HIV and antiretroviral exposure. The central scientific emphasis is twofold: first, to answer key questions about the clinical course and long-term health of adolescents and young adults who acquired HIV perinatally; and second, to evaluate the oral and broader systemic health consequences for children who were exposed to antiretroviral (ARV) medications in utero and during infancy. In practice, this means tracking and analyzing real-world, long-term outcomes in representative U.S. cohorts as children age into adolescence and adulthood, a period where chronic HIV management, comorbidities, and developmental issues often become more complex.
The award specifically supports a Data and Operations Center rather than individual clinical sites. The DOC is positioned as the coordinating hub responsible for keeping a multi-site cohort study running smoothly and consistently across locations. A major part of the role is coordinating clinical site activities, including organizing and supporting community advisory board participation and related community-facing activities. This reflects the expectation that PHACS continues to include meaningful stakeholder engagement, particularly important in pediatric HIV research where families, youth, and affected communities have distinct ethical, cultural, and practical concerns that can influence recruitment, retention, data quality, and dissemination.
Methodologically, the DOC is expected to provide study-wide analytical and statistical support, helping ensure that the research questions can be answered rigorously and that study procedures remain consistent across participating sites. Operationally, the DOC manages the core database infrastructure for PHACS and is responsible for database harmonization tasks, including reconciliation with collaborating databases. That reconciliation function is critical in large cohort programs because data often come from multiple sources (for example, clinical records, laboratory systems, specialized substudies, or external collaborating networks), and the value of the cohort depends on clean linkage, consistent definitions, and reliable longitudinal tracking.
This FOA is a discretionary funding opportunity using the cooperative agreement mechanism (U01), which typically indicates substantial NIH scientific and programmatic involvement during the project period compared with a standard research project grant. Only one award was expected. The estimated total funding amount is $17,975,000, and the award ceiling is also listed as $17,975,000, signaling the opportunity is essentially designed to fund a single DOC at that scale rather than multiple smaller awards.
Eligibility is broad and includes many types of U.S.-based organizations: state, local, county, and special district governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses; independent school districts; and eligible tribal entities and tribal colleges/universities. The announcement also explicitly includes a variety of designated institution types (for example, HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations). At the same time, it clearly restricts non-U.S. participation: non-domestic (non-U.S.) entities are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed. No cost sharing or matching is required.
From an administrative timeline standpoint, the opportunity was posted October 23, 2014, with an original and current closing date of January 2, 2015, and it was archived February 2, 2015. The activity categories listed span health and related social service domains, and multiple CFDA program numbers are cited, reflecting the cross-cutting nature of PHACS research, which can include infectious disease, child health and development, oral health, mental health, substance use, neuroscience, and related areas depending on the specific analyses and substudies supported through the cohort.
The primary deliverable implied by the FOA is a fully functioning, centralized operations and data backbone for PHACS that keeps sites aligned, supports consistent participant follow-up, ensures high-quality and well-governed data, and enables timely, rigorous analyses of the long-term outcomes of perinatal HIV infection and early-life ARV exposure in U.S. children as they mature. For full details, the announcement directs applicants to the NIH posting at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-15-029.html
Frequently Asked Questions (FAQs)
What is the funding opportunity called?
The opportunity is the Pediatric HIV/AIDS Cohort Study (PHACS) Data and Operations Center (DOC) (U01) funding opportunity, listed as RFA-HD-15-029.
Which federal agency is offering this opportunity?
This is a National Institutes of Health (NIH) funding opportunity.
What type of award mechanism is being used?
The announcement uses a cooperative agreement mechanism (U01). A cooperative agreement generally indicates substantial NIH scientific and programmatic involvement during the project period compared with a standard research project grant.
What is PHACS?
PHACS is a long-running U.S. research effort focused on understanding pediatric and adolescent outcomes related to HIV and antiretroviral exposure, using representative U.S. cohorts followed over time.
What is the central scientific emphasis of this opportunity?
The scientific focus is twofold: (1) answering key questions about the clinical course and long-term health of adolescents and young adults who acquired HIV perinatally, and (2) evaluating oral and broader systemic health consequences for children exposed to antiretroviral (ARV) medications in utero and during infancy.
Does this opportunity fund clinical sites or a coordinating center?
This opportunity specifically supports a Data and Operations Center (DOC), not individual clinical sites. The DOC is intended to serve as the coordinating hub for a multi-site cohort study.
What is the role of the PHACS Data and Operations Center (DOC)?
The DOC is responsible for keeping the multi-site cohort study running smoothly and consistently across locations. Responsibilities described include coordinating clinical site activities, providing study-wide analytical and statistical support, and managing the core database infrastructure and harmonization functions for PHACS.
What community or stakeholder engagement activities are expected?
The DOC is expected to coordinate clinical site activities that include organizing and supporting community advisory board participation and related community-facing activities. The FOA emphasizes meaningful stakeholder engagement, particularly given the ethical, cultural, and practical considerations in pediatric HIV research.
What analytical and statistical support is the DOC expected to provide?
The DOC is expected to provide study-wide analytical and statistical support to help ensure research questions can be answered rigorously and that study procedures remain consistent across participating sites.
What database and data management responsibilities are included?
The DOC is responsible for managing PHACS core database infrastructure and performing database harmonization, including reconciliation with collaborating databases. This includes linking and aligning data that may come from multiple sources and ensuring consistent definitions and reliable longitudinal tracking.
How many awards were expected to be made?
Only one award was expected.
What is the estimated total funding amount?
The estimated total funding amount is $17,975,000.
What is the award ceiling for this opportunity?
The award ceiling is listed as $17,975,000, which indicates the opportunity is designed to fund a single DOC at that overall scale.
Is cost sharing or matching required?
No cost sharing or matching is required.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S.-based organizations, including state, local, county, and special district governments; public and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses) as well as small businesses; independent school districts; and eligible tribal entities and tribal colleges/universities.
Are specific institution types explicitly included?
Yes. The announcement explicitly includes a variety of designated institution types, including HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations.
Are non-U.S. (foreign) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities are not eligible to apply.
Can a U.S. organization apply if it has a non-domestic component?
No. Non-domestic components of U.S. organizations are not eligible under this opportunity.
Are foreign components allowed under NIH policy?
No. Foreign components (as defined by NIH policy) are not allowed for this FOA.
When was the opportunity posted?
The opportunity was posted on October 23, 2014.
What was the closing date for applications?
The original and current closing date listed is January 2, 2015.
Has the opportunity been archived?
Yes. It was archived on February 2, 2015.
What topic areas or domains does the opportunity cover?
The activity categories span health and related social service domains. The description notes that PHACS research can be cross-cutting and may include areas such as infectious disease, child health and development, oral health, mental health, substance use, neuroscience, and related topics depending on analyses and substudies supported through the cohort.
What is the primary deliverable implied by the FOA?
The implied primary deliverable is a fully functioning, centralized operations and data backbone for PHACS that keeps sites aligned, supports consistent participant follow-up, ensures high-quality and well-governed data, and enables timely, rigorous analyses of long-term outcomes of perinatal HIV infection and early-life ARV exposure as participants mature.
Where can applicants find the full official announcement?
The FOA directs applicants to the NIH posting at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-15-029.html
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