Opportunity Information: Apply for RFA EB 15 003
Apply for RFA EB 15 003
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Pediatric Research Using Integrated Sensor Monitoring Systems (PRISMS) Network (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health.
- This funding opportunity was created on Mar 25, 2015 and posted on Mar 25, 2015.
- Applicants must submit their applications by Jun 1, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Eligible applicants include: State governments City or township governments Special district governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Private institutions of higher education Public and State controlled institutions of higher education For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Pediatric Research Using Integrated Sensor Monitoring Systems (PRISMS) Network (U54) funding opportunity (RFA-EB-15-003) is a National Institutes of Health (NIH) cooperative agreement that supports the creation of enabling informatics platforms for pediatric health monitoring research. The main goal is to build the data backbone needed to collect, manage, and interpret information coming from multiple kinds of sensors used with children, especially in studies focused on asthma. Rather than funding the sensor hardware itself, this particular announcement is aimed at the informatics layer that makes sensor data usable at scale: pulling data in from devices, integrating it across sources, processing and cleaning it, presenting it in ways researchers can understand, and securely transferring standardized outputs to a central coordinating hub.
This U54 opportunity is one part of a coordinated, three-component PRISMS Program that was designed to function as a tightly linked ecosystem. In the overall program structure, one companion funding announcement (RFA-EB-15-002) supports development of the environmental, physiological, and behavioral sensors themselves, while another (RFA-EB-15-004) supports a data and software coordination and integration center. The PRISMS Network (this FOA, RFA-EB-15-003) sits between those efforts. Its role is to ensure that data generated by the sensor developers can be reliably acquired and transformed into consistent, high-quality research-ready datasets, then securely uploaded to the central coordinating center. The emphasis on close collaboration across all three awards reflects the practical reality that sensor systems only become useful research tools when hardware, software, standards, and governance work together end-to-end.
From a scientific and public health standpoint, the PRISMS Program is framed around creating integrated, sensor-based health monitoring systems that can measure pediatric environmental exposures, physiological signals, and behaviors in real-world settings. The immediate application area highlighted is epidemiological studies of childhood asthma, where understanding triggers and daily variability often depends on continuous or frequent measurements taken outside the clinic. The program also signals an intent to expand beyond asthma over time to other chronic pediatric diseases, meaning the informatics solutions are expected to be extensible and adaptable rather than narrowly built for a single study design.
Because this is a cooperative agreement (U54), applicants should expect substantial NIH involvement compared with a standard research grant. In practice, that typically means the funded teams work in an organized network with shared milestones, coordinated technical decisions, and active collaboration with NIH staff and the companion awardees. The deliverables implied by the description include robust methods for multi-sensor data acquisition, tools and pipelines for integration and processing, visualization capabilities to support interpretation and quality control, and secure mechanisms for transmitting platform results to the central data/software coordination and integration center. Interoperability, data security, and consistent formatting are central themes, since the entire point is to make disparate sensor outputs function as a unified research resource.
Administratively, the opportunity is listed as a discretionary grant program under CFDA 93.286 (Discovery and Applied Research for Technological Innovations to Improve Human Health). NIH estimated total funding for this FOA at $3,000,000. The announcement was posted March 25, 2015, with an original and current closing date of June 1, 2015, and it was archived July 2, 2015. There is no cost sharing or matching requirement, which can simplify budgeting for institutions that do not have dedicated matching funds.
Eligibility is broad across public and private sectors, reflecting the interdisciplinary nature of sensor informatics work. Eligible applicants include a wide range of U.S.-based entities such as state, county, city/township, and special district governments; independent school districts; public housing authorities/Indian housing authorities; tribal governments and tribal organizations; public and private institutions of higher education; nonprofits with and without 501(c)(3) status (with the noted exception categories); and for-profit organizations (including small businesses, with other for-profits also eligible). The eligibility section also explicitly names categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, AANAPISIs, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Foreign institutions and non-U.S. organizational components are not eligible to apply, although foreign components as defined in the NIH Grants Policy Statement are allowed, which generally means limited, well-justified foreign participation can be included under a U.S. applicant when it is essential to the project.
In short, this PRISMS Network U54 opportunity was designed to fund the informatics infrastructure that turns pediatric sensor streams into secure, integrated, analyzable datasets suitable for large-scale epidemiological research. It prioritizes end-to-end functionality across device data capture, integration and processing, visualization, and secure submission to a central coordinating center, all within a coordinated multi-award program aimed first at asthma and later at broader chronic disease research in children.
Frequently Asked Questions (FAQs): Pediatric Research Using Integrated Sensor Monitoring Systems (PRISMS) Network (U54) - RFA-EB-15-003
1) What is the PRISMS Network (U54) funding opportunity?
The Pediatric Research Using Integrated Sensor Monitoring Systems (PRISMS) Network (U54) (RFA-EB-15-003) is a National Institutes of Health (NIH) cooperative agreement that supports the creation of enabling informatics platforms for pediatric health monitoring research. The focus is on building the informatics "data backbone" needed to make multi-sensor pediatric health monitoring studies work at scale.
2) What is the main purpose of this opportunity?
The main goal is to support informatics infrastructure that can collect, manage, integrate, process, interpret, and securely transmit data coming from multiple kinds of sensors used with children. The intent is to turn raw, disparate sensor streams into consistent, high-quality, research-ready datasets.
3) Does this funding support building or buying sensor hardware?
No. This announcement is aimed at the informatics layer rather than the sensor hardware itself. It emphasizes the software, standards, pipelines, and secure data handling needed to make sensor outputs usable for research at scale.
4) What kinds of sensor data does the PRISMS Network focus on?
The PRISMS Program is framed around integrated sensor-based health monitoring systems that can measure pediatric environmental exposures, physiological signals, and behaviors in real-world settings. This U54 focuses on the informatics needed to acquire and work with data from multiple sensor sources.
5) What disease area is highlighted for the initial application?
The immediate application area highlighted is epidemiological studies of childhood asthma, where understanding triggers and day-to-day variability often depends on continuous or frequent measurements taken outside of clinical settings.
6) Is the PRISMS Network limited to asthma research only?
No. While asthma is the initial focus area highlighted, the program signals an intent to expand over time to other chronic pediatric diseases. Informatics solutions are therefore expected to be extensible and adaptable rather than built only for a single study design.
7) What does it mean that this award mechanism is a cooperative agreement (U54)?
Because this is a cooperative agreement (U54), applicants should expect substantial NIH involvement compared with a standard research grant. In practice, this typically includes organized network participation, shared milestones, coordinated technical decisions, and active collaboration with NIH staff and companion awardees.
8) What are the expected informatics functions or deliverables supported by this FOA?
Based on the description, the informatics platform work includes robust methods for multi-sensor data acquisition; tools and pipelines for integration, processing, and cleaning; visualization capabilities to support interpretation and quality control; and secure mechanisms for transmitting standardized outputs to the central coordinating hub.
9) What is meant by building a "data backbone" for pediatric sensor monitoring research?
In this context, a "data backbone" means the end-to-end informatics infrastructure that makes sensor data usable across studies and sites: pulling in data from devices, integrating data across sources, processing and cleaning it, presenting it in understandable ways, and securely transferring standardized outputs to a central coordinating center.
10) How does this PRISMS Network award fit into the overall PRISMS Program?
This U54 opportunity is one part of a coordinated, three-component PRISMS Program designed to function as a tightly linked ecosystem. One companion announcement (RFA-EB-15-002) supports development of the sensors themselves, and another (RFA-EB-15-004) supports a data and software coordination and integration center. The PRISMS Network (RFA-EB-15-003) sits between those efforts to ensure sensor data can be reliably acquired, transformed into consistent datasets, and securely uploaded to the central coordinating center.
11) Why is collaboration across multiple awards emphasized?
The program emphasizes close collaboration because sensor systems only become useful research tools when hardware, software, standards, and governance work together end-to-end. This FOA explicitly reflects the need for coordinated technical decisions and interoperability across the sensor developers, the network informatics platforms, and the central coordinating center.
12) Where does the PRISMS Network send its standardized data outputs?
The PRISMS Network is expected to securely transfer standardized outputs to a central coordinating hub, described as the data and software coordination and integration center supported under a companion funding announcement (RFA-EB-15-004).
13) What are the key themes emphasized for the informatics platform?
Interoperability, data security, and consistent formatting are central themes. The overall aim is to make disparate sensor outputs function as a unified research resource by standardizing, securing, and integrating the data end-to-end.
14) What is the CFDA number associated with this opportunity?
The opportunity is listed under CFDA 93.286 (Discovery and Applied Research for Technological Innovations to Improve Human Health).
15) What was the estimated total funding for this FOA?
NIH estimated total funding for this FOA at $3,000,000.
16) Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
17) When was the opportunity posted and when did it close?
The announcement was posted March 25, 2015. The original and current closing date listed is June 1, 2015.
18) Is this funding opportunity still active?
No. The opportunity was archived July 2, 2015.
19) Who is eligible to apply?
Eligibility is broad across public and private sectors and includes many U.S.-based entities: state, county, city/township, and special district governments; independent school districts; public housing authorities/Indian housing authorities; tribal governments and tribal organizations; public and private institutions of higher education; nonprofits with and without 501(c)(3) status (with noted exception categories); and for-profit organizations including small businesses (with other for-profits also eligible).
20) Are minority-serving institutions and community-based organizations included in the eligibility list?
Yes. The eligibility section explicitly names categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, AANAPISIs, faith-based or community-based organizations, and regional organizations, among others.
21) Are U.S. territories or eligible federal agencies allowed to apply?
Yes. The eligibility section explicitly includes U.S. territories or possessions and eligible federal agencies.
22) Are foreign institutions eligible to apply directly?
No. Foreign institutions and non-U.S. organizational components are not eligible to apply directly.
23) Can a U.S. applicant include foreign participation in the project?
Yes, limited foreign participation can be included under a U.S. applicant if it qualifies as a foreign component as defined in the NIH Grants Policy Statement. The description notes that foreign components are allowed, generally meaning well-justified foreign participation can be included when it is essential to the project.
24) What types of research settings are emphasized for the sensor monitoring systems?
The PRISMS Program emphasizes real-world settings, reflecting the need for continuous or frequent measurements taken outside the clinic, especially for conditions like asthma where triggers and variability often occur in day-to-day environments.
25) What is the practical role of the PRISMS Network within the three-part ecosystem?
The PRISMS Network is positioned as the bridge between sensor development and central coordination. Its practical role is to ensure sensor data can be reliably acquired and transformed into consistent, high-quality datasets and then securely uploaded to the central data/software coordination and integration center.
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