Opportunity Information: Apply for RFA HD 16 012

  • The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Pelvic Floor Disorders Network Clinical Sites (UG1)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Jul 31, 2015 and posted on Jul 31, 2015.
  • Applicants must submit their applications by Nov 10, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $2,200,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $180,000.00 in funding.
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities For profit organizations other than small businesses City or township governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Special district governments Small businesses County governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Public and State controlled institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:

The Pelvic Floor Disorders Network Clinical Sites (UG1) opportunity (Funding Opportunity Number RFA-HD-16-012) was a National Institutes of Health (NIH) cooperative agreement released through the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). It sought to fund clinical sites that would work as part of an ongoing, multicenter clinical research program focused on pelvic floor disorders in women. Rather than supporting isolated, single-institution studies, the intent was to build and maintain a coordinated network of participating sites that could enroll well-defined patient populations and contribute to shared protocols and multicenter trials under substantial NIH program involvement, which is a key feature of the UG1 cooperative agreement mechanism.

The scientific focus centered on common and burdensome pelvic floor disorders, specifically including urinary incontinence, fecal incontinence, pelvic organ prolapse, and other sensory and emptying problems affecting the lower urinary tract and gastrointestinal tract. The FOA emphasized research on real-world clinical and health aspects of these conditions. That included evaluating surgical and nonsurgical treatments, studying pharmacologic approaches, and measuring outcomes across the broad range of available therapies. It also explicitly welcomed work on social and behavioral factors that contribute to pelvic floor disorders or influence treatment success, as well as prevention strategies aimed at reducing incidence, severity, or recurrence.

A notable aspect of the announcement was that it allowed translational components when they strengthened the clinical mission. Applicants could incorporate studies exploring etiology and pathophysiology, particularly where the network setting and carefully characterized clinical populations made those questions more answerable. The overarching goal was practical and patient-centered: developing innovative solutions to persistent challenges faced by women with pelvic floor disorders, and ultimately reducing the burden on women and their families through better evidence, better care pathways, and improved outcomes.

Administratively, this was a discretionary funding opportunity in the Health activity area (CFDA 93.865, Child Health and Human Development Extramural Research). The FOA was posted July 31, 2015, with an original and final application due date of November 10, 2015, and it was later archived on December 11, 2015. The estimated total funding listed was $2,200,000, and the award ceiling was $180,000. Cost sharing or matching was not required.

Eligibility was broad across U.S.-based organizations and governments, including public and private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3)), for-profit entities (including small businesses and other for-profits), and various local, county, state, and tribal government entities, as well as public housing authorities and special district governments. The FOA also called out additional eligible applicant categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and other minority-serving institutions, along with faith-based or community-based organizations and eligible federal agencies. At the same time, it clearly excluded non-U.S. entities: foreign institutions could not apply, non-domestic components of U.S. organizations were not eligible, and foreign components as defined by NIH policy were not allowed.

In practical terms, institutions applying were being asked to function as active clinical network sites capable of participating in multicenter studies on pelvic floor disorders in women, contributing to standardized study implementation, and helping generate strong, generalizable evidence about treatments, outcomes, behavioral and social influences, and prevention, with optional translational work when it leveraged the network’s clinical cohorts. The full announcement was linked through the NIH grants guide at http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-16-012.html, and NIH’s Office of Extramural Research webmaster contacts were provided for access or technical issues.

Frequently Asked Questions (FAQs)

What is the Pelvic Floor Disorders Network Clinical Sites (UG1) opportunity?

It is an NIH cooperative agreement funding opportunity (UG1) released by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to support clinical sites participating in an ongoing, multicenter clinical research program focused on pelvic floor disorders in women.

What is the Funding Opportunity Number (FOA number)?

The Funding Opportunity Number is RFA-HD-16-012.

Which NIH institute released this funding opportunity?

The opportunity was released through NICHD (Eunice Kennedy Shriver National Institute of Child Health and Human Development), part of the National Institutes of Health (NIH).

What type of award mechanism is UG1, and what does that imply?

UG1 is a cooperative agreement mechanism. In this opportunity, it meant the clinical sites would participate in network-based, multicenter research with substantial NIH program involvement, rather than operating as isolated, single-institution research projects.

What is the overall purpose of funding clinical sites under this FOA?

The purpose was to build and maintain a coordinated network of participating clinical sites that can enroll well-defined patient populations and contribute to shared protocols and multicenter trials to generate strong, generalizable evidence on pelvic floor disorders in women.

Is this funding intended for single-institution studies?

No. The FOA emphasized a coordinated, multicenter network approach, with sites contributing to common protocols and multicenter clinical research rather than isolated studies.

What clinical conditions are included in the scientific focus?

The FOA focused on common and burdensome pelvic floor disorders in women, including urinary incontinence, fecal incontinence, pelvic organ prolapse, and other sensory and emptying problems affecting the lower urinary tract and gastrointestinal tract.

What kinds of research topics and approaches were encouraged?

The announcement emphasized real-world clinical and health aspects of pelvic floor disorders, including evaluation of surgical and nonsurgical treatments, pharmacologic approaches, and outcomes measurement across available therapies.

Does the FOA include social or behavioral research?

Yes. It explicitly welcomed work on social and behavioral factors that contribute to pelvic floor disorders or influence treatment success.

Were prevention strategies within scope?

Yes. The FOA welcomed prevention strategies aimed at reducing incidence, severity, or recurrence of pelvic floor disorders.

Could applicants include translational research components?

Yes, translational components were allowed when they strengthened the clinical mission. Examples described included studies exploring etiology and pathophysiology when the network setting and carefully characterized clinical populations made those questions more answerable.

What was the intended impact of the research supported by this network?

The stated goal was practical and patient-centered: developing innovative solutions to persistent challenges faced by women with pelvic floor disorders, improving evidence and care pathways, and reducing the burden on women and their families through better outcomes.

What activity area and CFDA number were associated with this opportunity?

This was in the Health activity area and listed under CFDA 93.865 (Child Health and Human Development Extramural Research).

When was the FOA posted, and what were the application due dates?

The FOA was posted on July 31, 2015. The original and final application due date was November 10, 2015.

Is this funding opportunity still open?

No. The FOA was later archived on December 11, 2015.

What was the estimated total funding amount?

The estimated total funding listed was $2,200,000.

What was the award ceiling?

The award ceiling was $180,000.

Was cost sharing or matching required?

No. Cost sharing or matching was not required.

Who was eligible to apply?

Eligibility was broad across U.S.-based organizations and governments, including public and private institutions of higher education, nonprofits (501(c)(3) and non-501(c)(3)), for-profit entities (including small businesses), and local, county, state, tribal, and other eligible government entities (including public housing authorities and special district governments). The FOA also highlighted eligibility for HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, other minority-serving institutions, faith-based or community-based organizations, and eligible federal agencies.

Are foreign institutions or non-U.S. components eligible?

No. The FOA excluded non-U.S. entities: foreign institutions could not apply, non-domestic components of U.S. organizations were not eligible, and foreign components (as defined by NIH policy) were not allowed.

What would an applying institution be expected to do as a funded clinical site?

Applicants were expected to function as active clinical network sites capable of participating in multicenter studies on pelvic floor disorders in women, contributing to standardized study implementation, enrolling well-defined patient populations, and supporting shared protocols and multicenter trials under NIH program involvement.

Where can the full funding announcement be found?

The full announcement was linked through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-16-012.html.

Who should be contacted for access or technical issues related to the announcement?

The announcement indicated that NIH Office of Extramural Research (OER) webmaster contacts were provided for access or technical issues.

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