Opportunity Information: Apply for RFA HD 12 207

  • The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Perinatally HIV Infected Youth In Africa and Asia (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Jun 9, 2011 and posted on Jun 9, 2011.
  • Applicants must submit their applications by Nov 17, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $600,000.00 in funding.
  • Eligible applicants include: Special district governments County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education State governments Native American tribal governments (Federally recognized) For profit organizations other than small businesses Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Small businesses.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:

The Perinatally HIV Infected Youth In Africa and Asia (R01) funding opportunity (RFA-HD-12-207) is a discretionary NIH research grant program issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Its central purpose is to support research that examines what happens to children who acquired HIV at birth (perinatal infection) as they increasingly survive into adolescence and young adulthood, particularly in Africa and Asia where the burden of pediatric HIV has been high and where long-term outcomes are still not as well characterized. The emphasis is on understanding the impact of HIV infection itself and the effects of HIV treatment over time in these young people, including the consequences of long-term antiretroviral therapy exposure that begins in infancy or childhood and continues through critical developmental stages.

This opportunity uses the R01 mechanism, meaning it is intended for well-developed, hypothesis-driven research projects with clear aims, rigorous methods, and the ability to generate strong, generalizable evidence. The overall focus is evaluative: applicants are expected to design studies that measure and analyze outcomes associated with perinatal HIV and its treatment as youth age, rather than only describing prevalence. In practical terms, this can include clinical outcomes, developmental and reproductive health issues, treatment response and complications, psychosocial and behavioral outcomes, and other adolescent-to-young-adult transition issues that are uniquely shaped by lifelong HIV infection and chronic medication exposure. The geographic scope is explicitly centered on Africa and Asia, reflecting both need and the scientific importance of studying youth in settings where health systems, co-infections, nutrition, stigma, and treatment access patterns may differ from high-income countries.

Financially, NIH estimated a total of about $4,000,000 in available funding under this announcement, with an award ceiling of $600,000. The announcement specifies that cost sharing or matching is not required, which is typical for many NIH research grants and lowers barriers for applicants who might not have access to non-federal co-funding. The funding activity category is listed under Health, Income Security, and Social Services, and the CFDA number is 93.865 (Child Health and Human Development Extramural Research), tying the program to NICHDs broader mission around child and adolescent health and development.

Eligibility is broad and includes a wide range of public, private, academic, governmental, and community-based entities. Eligible applicants include nonprofits (both 501(c)(3) and non-501(c)(3)), public and private institutions of higher education, for-profit organizations (other than small businesses), small businesses, state and local governments (including county, city/township, and special district governments), independent school districts, and public housing authorities/Indian housing authorities. The FOA also explicitly welcomes tribal governments and tribal organizations (both federally recognized and other than federally recognized), and it extends eligibility to a number of institution types that often serve underrepresented populations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribal Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions. Importantly for a program focused on Africa and Asia, non-U.S. entities (foreign organizations), regional organizations, U.S. territories or possessions, and foreign components of U.S. organizations are allowed, enabling on-the-ground research leadership and partnerships in the regions of interest.

Key dates indicate that the opportunity was posted and created on June 9, 2011, with an original and current closing date of November 17, 2011, and an archive date of December 18, 2011. While this means the specific FOA is now archived and no longer accepting applications, the summary details are still useful for understanding the type of research NICHD sought to stimulate at that time and for locating the full historical announcement and any related programmatic priorities that may have carried forward into later funding initiatives.

For additional details, the full announcement was made available through the NIH grants guide at the provided link (http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-12-207.html). The contact listed for access or technical issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, which is aimed at resolving problems with viewing or linking to the announcement rather than providing scientific/program guidance.

Frequently Asked Questions (FAQs)

What is this funding opportunity?

This opportunity is the Perinatally HIV Infected Youth In Africa and Asia (R01) funding opportunity announcement (FOA) RFA-HD-12-207. It is a discretionary NIH research grant program issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

What is the main purpose of RFA-HD-12-207?

The central purpose is to support research on what happens to children who acquired HIV at birth (perinatal infection) as they increasingly survive into adolescence and young adulthood. The FOA emphasizes Africa and Asia, where pediatric HIV burden has been high and long-term outcomes have been less well characterized.

What populations are the focus of the research?

The focus is on youth who were infected with HIV perinatally (at birth) and who are now aging into adolescence and young adulthood, particularly in African and Asian settings.

Which regions does the FOA prioritize?

The geographic scope is explicitly centered on Africa and Asia.

Why does the FOA emphasize Africa and Asia?

The FOA highlights the scientific and public health importance of studying perinatally infected youth in settings where factors like health systems, co-infections, nutrition, stigma, and treatment access patterns may differ from high-income countries.

What types of research questions or outcomes are encouraged?

The FOA encourages studies that measure and analyze outcomes associated with perinatal HIV infection and its treatment as youth age. Examples of outcome areas mentioned include clinical outcomes, developmental outcomes, reproductive health issues, treatment response and complications, psychosocial and behavioral outcomes, and transition issues from adolescence to young adulthood shaped by lifelong HIV infection and chronic medication exposure.

Is the FOA focused on describing prevalence, or on evaluating outcomes?

The stated emphasis is evaluative. Applicants are expected to design studies that measure and analyze outcomes over time, rather than only describing prevalence.

What is the grant mechanism used for this opportunity?

This FOA uses the NIH R01 mechanism.

What does it mean that this is an R01 opportunity?

An R01 is intended for well-developed, hypothesis-driven research projects with clear aims, rigorous methods, and the ability to produce strong, generalizable evidence.

What role does HIV treatment play in the research emphasis?

The FOA emphasizes understanding both the impact of HIV infection itself and the effects of HIV treatment over time, including consequences of long-term antiretroviral therapy exposure that begins in infancy or childhood and continues through key developmental stages.

How much funding was expected to be available under this announcement?

NIH estimated a total of about $4,000,000 in available funding under this announcement.

What is the maximum award amount (award ceiling) mentioned?

The award ceiling listed in the summary is $600,000.

Is cost sharing or matching required?

No. The announcement specifies that cost sharing or matching is not required.

What is the funding activity category?

The funding activity category is listed under Health, Income Security, and Social Services.

What CFDA number is associated with this opportunity?

The CFDA number listed is 93.865, described as Child Health and Human Development Extramural Research.

Who is eligible to apply?

Eligibility is broad and includes many types of public, private, academic, governmental, and community-based entities. The summary explicitly includes nonprofits (501(c)(3) and non-501(c)(3)), public and private institutions of higher education, for-profit organizations (other than small businesses), small businesses, state and local governments (including county, city/township, and special district governments), independent school districts, and public housing authorities/Indian housing authorities.

Are tribal governments and tribal organizations eligible?

Yes. The summary explicitly welcomes tribal governments and tribal organizations, including both federally recognized and other than federally recognized entities.

Are institutions serving underrepresented populations explicitly included?

Yes. The FOA explicitly includes institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribal Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions.

Can non-U.S. organizations apply?

Yes. Non-U.S. entities (foreign organizations), regional organizations, U.S. territories or possessions, and foreign components of U.S. organizations are allowed, supporting leadership and partnerships in Africa and Asia.

When was this opportunity posted and created?

The key dates indicate it was posted and created on June 9, 2011.

What was the application closing date?

The original and current closing date listed is November 17, 2011.

Is this FOA still accepting applications?

No. The archive date is December 18, 2011, and the provided dates indicate the FOA is archived and no longer accepting applications.

If it is archived, why is the FOA information still useful?

The summary notes that, even though the FOA is no longer open, the details can still help users understand the kind of research NICHD sought to stimulate at the time and help locate the full historical announcement and any related programmatic priorities that may have continued in later initiatives.

Where can the full historical announcement be found?

The full announcement is available via the NIH Grants Guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-12-207.html

Who is listed as the contact for access or technical issues?

The contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

What type of help is the listed contact intended for?

The summary indicates this contact is aimed at resolving problems with viewing or linking to the announcement, rather than providing scientific or program guidance.

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Previous opportunity: Patient Safety Research During Neonatal Care (R21)

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