Opportunity Information: Apply for RFA GM 15 002
Apply for RFA GM 15 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Pharmacogenomics Knowledge Base (R24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on May 7, 2014 and posted on May 7, 2014.
- Applicants must submit their applications by Oct 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,400,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,600,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Private institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) County governments For profit organizations other than small businesses City or township governments Small businesses Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Independent school districts Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Pharmacogenomics Knowledge Base (R24) funding opportunity (RFA-GM-15-002) is a National Institutes of Health (NIH) discretionary grant announcement focused on supporting a single, high-impact pharmacogenomics knowledge base that serves as a shared research resource for the entire scientific community. The goal is to maintain and advance a centralized, community-facing platform that collects, organizes, and delivers pharmacogenomics knowledge in ways that are broadly useful for research and, ultimately, improved understanding of how genetic variation influences drug response. A key point in the announcement is that an established resource already exists (PharmGKB), and the National Institute of General Medical Sciences (NIGMS) intends to continue funding one knowledge base; however, the competition is open, meaning any qualified applicant can propose to operate and enhance the resource. Because the project is meant to function as a major community infrastructure asset, the FOA strongly encourages prospective applicants to consult with program staff in advance to confirm that the proposed scope and plans align well with the opportunity.
In practical terms, this opportunity is about sustaining and improving a curated, accessible knowledge base that can be used across the pharmacogenomics field. While the short description does not list specific required components, the intent implies a robust, reliable, and widely accessible data and knowledge resource, likely involving ongoing acquisition of relevant evidence, careful curation and standardization, and user-friendly access for researchers. The emphasis on a “high impact†resource also signals expectations around broad utility, scientific rigor, and visibility, including the ability to support diverse users and use cases across biomedical research. The “R24†mechanism is commonly used for resource-related projects, reinforcing that the deliverable is infrastructure and community value rather than a narrow hypothesis-driven study.
The FOA was posted May 7, 2014, with an original and current closing date of October 7, 2014, and an archive date of November 7, 2014. NIH anticipated making one award under this announcement, underscoring the “continue one knowledge base†intention and the competitive selection of a single awardee to run the national-level resource. The estimated total funding level is $2.4 million, with an award ceiling of $1.6 million, and there is no cost sharing or matching requirement. The program is listed under CFDA 93.859 (Biomedical Research and Research Training), and the activity category is Health.
Eligibility is broad across U.S.-based organizational types, reflecting the infrastructure nature of the project and NIH’s interest in attracting strong teams regardless of institutional sector. Eligible applicants include public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities other than institutions of higher education), state and local governments (including county and city/township governments), special district governments, independent school districts, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations (including federally recognized tribal governments and certain other tribal entities). The FOA also explicitly notes additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as eligible federal agencies and faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. Non-U.S. (foreign) institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible to apply; however, foreign components (as NIH defines them in the NIH Grants Policy Statement) are allowed, which leaves room for certain types of international collaboration under NIH rules while keeping the applicant organization domestic.
For reference and further detail, NIH provided an additional information link to the full announcement (http://grants.nih.gov/grants/guide/rfa-files/RFA-GM-15-002.html). The contact information in the source notes the NIH Office of Extramural Research (OER) webmaster email for technical difficulties accessing or linking to the announcement (FBOWebmaster@OD.NIH.GOV). Overall, the opportunity is best understood as a competitive solicitation to operate and evolve the primary U.S. pharmacogenomics knowledge base resource, with expectations of strong community impact, continuity of an existing function, and close alignment with NIGMS program goals.
Frequently Asked Questions (FAQs)
What is the Pharmacogenomics Knowledge Base (R24) funding opportunity?
This is a National Institutes of Health (NIH) discretionary funding opportunity announcement (FOA) to support a single, high-impact pharmacogenomics knowledge base that serves as a shared research resource for the scientific community. The intent is to maintain and advance a centralized, community-facing platform that collects, organizes, and delivers pharmacogenomics knowledge for broad research use and, ultimately, improved understanding of how genetic variation influences drug response.
What is the FOA number for this opportunity?
The FOA number is RFA-GM-15-002.
What funding mechanism is being used?
The mechanism is an NIH R24, which is commonly used for resource-related projects. This reinforces that the deliverable is community infrastructure and broad utility rather than a narrow, hypothesis-driven research study.
What is the main goal of the project being funded?
The goal is to sustain and improve a curated, accessible pharmacogenomics knowledge base that can be used across the field, functioning as major community infrastructure. The platform is expected to collect, organize, and deliver pharmacogenomics knowledge in ways that are broadly useful to diverse users and use cases across biomedical research.
Is NIH planning to fund more than one knowledge base?
No. NIH anticipated making one award under this announcement and indicated an intention to continue funding one knowledge base, with a competitive selection process to choose a single awardee to operate and enhance the national-level resource.
Does an existing pharmacogenomics knowledge base already exist?
Yes. The announcement notes that an established resource already exists (PharmGKB), and the National Institute of General Medical Sciences (NIGMS) intends to continue funding one knowledge base. However, the competition is open, meaning any qualified applicant can propose to operate and enhance the resource.
Is the competition open to new applicants, or only to the current operator?
The competition is open. Even though an established resource exists and NIH intends to continue one knowledge base, any qualified applicant may apply to propose operation and enhancement of the resource.
Which NIH institute is associated with the intent to continue funding the knowledge base?
The National Institute of General Medical Sciences (NIGMS) is identified as intending to continue funding one knowledge base under this opportunity.
What kinds of activities are implied for the knowledge base (based on the announcement summary)?
While specific required components are not listed in the short description, the intent implies a robust and widely accessible data and knowledge resource. This likely includes ongoing acquisition of relevant evidence, careful curation and standardization, and user-friendly access for researchers, with an emphasis on reliability, scientific rigor, broad utility, and visibility.
Why does the FOA encourage applicants to consult with program staff in advance?
Because the project is intended to function as a major community infrastructure asset, the FOA strongly encourages prospective applicants to consult with program staff ahead of submission to confirm that the proposed scope and plans align well with the opportunity.
When was the FOA posted?
The FOA was posted on May 7, 2014.
What was the application closing date?
The original and current closing date was October 7, 2014.
When was the FOA archived?
The archive date was November 7, 2014.
How many awards did NIH anticipate making?
NIH anticipated making one award.
What is the estimated total funding level for this opportunity?
The estimated total funding level is $2.4 million.
What is the award ceiling?
The award ceiling is $1.6 million.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement.
What CFDA number is associated with this program?
The program is listed under CFDA 93.859 (Biomedical Research and Research Training).
What is the activity category?
The activity category is Health.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizational types. Eligible applicants include public and private institutions of higher education; nonprofits (including 501(c)(3) and certain non-501(c)(3) entities other than institutions of higher education); state and local governments (including county and city/township governments); special district governments; independent school districts; public housing authorities/Indian housing authorities; and tribal governments and tribal organizations (including federally recognized tribal governments and certain other tribal entities).
Are minority-serving institutions explicitly included as eligible applicants?
Yes. The FOA explicitly notes additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are federal agencies eligible to apply?
Yes. The FOA notes eligible federal agencies among eligible applicants.
Are faith-based or community-based organizations eligible?
Yes. The FOA notes faith-based or community-based organizations as eligible applicants.
Are U.S. territories or possessions eligible?
Yes. The FOA includes U.S. territories or possessions among eligible applicants.
Are non-U.S. (foreign) institutions eligible to apply as the applicant organization?
No. Non-U.S. (foreign) institutions are not eligible to apply.
Can a U.S. organization include non-U.S. components?
No. Non-U.S. components of U.S. organizations are not eligible to apply. However, foreign components (as NIH defines them in the NIH Grants Policy Statement) are allowed, which can enable certain forms of international collaboration under NIH rules while keeping the applicant organization domestic.
Where can applicants find the full announcement?
NIH provided an additional information link to the full announcement at: http://grants.nih.gov/grants/guide/rfa-files/RFA-GM-15-002.html
Who should be contacted for technical difficulties accessing or linking to the announcement?
The source notes the NIH Office of Extramural Research (OER) webmaster email for technical difficulties: FBOWebmaster@OD.NIH.GOV
What is the overall purpose of funding a single knowledge base?
The opportunity is framed as sustaining and evolving the primary U.S. pharmacogenomics knowledge base resource as a shared community asset, with expectations of strong community impact, continuity of an existing function, and close alignment with NIGMS program goals.
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