Opportunity Information: Apply for PA 15 270
Apply for PA 15 270
- The National Institutes of Health in the education environment food and nutrition health income security and social services sector is offering a public funding opportunity titled "PHS 2015 02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR R41/R42)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.121 Oral Diseases and Disorders Research 93.172 Human Genome Research 93.173 Research Related to Deafness and Communication Disorders 93.213 Research and Training in Complementary and Integrative Health 93.233 National Center on Sleep Disorders Research 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.307 Minority Health and Health Disparities Research 93.350 National Center for Advancing Translational Sciences 93.351 Research Infrastructure Programs 93.361 Nursing Research 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.399 Cancer Control 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research 93.879 Medical Library Assistance.
- This funding opportunity was created on Jun 4, 2015 and posted on Jun 4, 2015.
- Applicants must submit their applications by Apr 5, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
- Other Eligible Applicants include the following Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, may be allowed.
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Opportunity Summary:
PHS 2015-02, the NIH Omnibus Solicitation for Small Business Technology Transfer (STTR) Grant Applications (Parent STTR R41/R42), is a broad NIH funding opportunity designed to help U.S. small businesses move promising early-stage biomedical, behavioral, and health-related technologies from research into development through a structured partnership with a U.S. research institution. The core idea of the STTR program is that innovation often comes from small companies, while key scientific expertise, specialized equipment, and complementary capabilities often sit within universities, medical centers, and nonprofit research organizations. This FOA invites eligible U.S. small business concerns to propose research and development projects that match the missions of participating NIH Institutes and Centers, covering a wide range of diseases, conditions, and enabling health technologies. Because it is an omnibus, “parent” solicitation, it is meant to be topic-flexible across NIH’s interests rather than limited to a narrow single disease area, as long as the proposal aligns with an NIH awarding component’s priorities.
This opportunity uses the STTR phased award structure under activity codes R41 (Phase I) and R42 (Phase II). In practical terms, Phase I typically supports proof-of-concept work, feasibility studies, and initial prototype development to demonstrate that the approach is technically sound and worth further investment. Phase II generally supports the heavier development work that follows successful Phase I results, such as advanced prototyping, preclinical validation, further engineering, software development and testing, product refinement, and other steps needed to position the technology for commercialization or broader adoption. NIH’s interest is not only scientific merit, but also whether the work can realistically lead to a product, process, or service that improves human health, so applicants are expected to frame the R and D plan with a clear pathway toward real-world impact.
The eligible applicant pool is limited to small businesses, reflecting the purpose of the STTR program. Foreign (non-U.S.) entities cannot apply as the small business applicant, and non-U.S. components of U.S. organizations are also not eligible to apply. However, the announcement notes that “foreign components,” as NIH defines them in the NIH Grants Policy Statement, may be allowable in some cases, meaning certain parts of the work might be performed abroad if they meet NIH policy requirements and are well-justified. There is no cost sharing or matching requirement, which lowers the barrier for early-stage companies that may not have substantial cash reserves. The funding instrument is a grant, categorized under discretionary funding, which typically means the agency has flexibility to make awards based on scientific and programmatic priorities and the availability of funds.
The scope of NIH areas covered is wide and is reflected in the CFDA program listings associated with the announcement. These include major research portfolios such as environmental health, oral health, human genome research, deafness and communication disorders, complementary and integrative health, sleep disorders, mental health, alcohol and substance use, drug abuse and addiction, minority health and health disparities, translational sciences, research infrastructure, nursing research, and a full range of cancer research areas (cause and prevention, detection and diagnosis, treatment, biology, and control). It also spans cardiovascular, lung, and blood diseases; arthritis and musculoskeletal/skin diseases; diabetes, digestive, and kidney diseases; neuroscience and neurological disorders; allergy and infectious diseases; microbiology and infectious diseases; general biomedical research and training; child health and human development; aging; vision research; and medical library assistance. In effect, if a small company is developing a biomedical device, diagnostic, therapeutic, digital health tool, research platform, data resource, or other health-relevant technology, there is a reasonable chance it can find a fit within one of these NIH missions, provided the application makes that alignment explicit.
Administratively, this FOA was posted and created on June 4, 2015, with an original and current closing date listed as April 5, 2016, and an archive date of May 6, 2016. That means it was an active solicitation during that period and is now archived, but it remains useful as a reference point for how NIH structures parent STTR opportunities and what kinds of eligibility and scope statements they use. Applicants were directed to the full announcement hosted by NIH (the grants.nih.gov “PA-15-270” page) for detailed instructions, requirements, and participating institute information. For technical issues accessing the full announcement or linking problems, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, the opportunity is best understood as a centralized entry point for small businesses that want NIH support to develop health-related technologies in collaboration with a research institution, using the Phase I/Phase II STTR structure to de-risk an innovation scientifically and technically while keeping commercialization and deployment as an explicit long-term objective.
Frequently Asked Questions (FAQs)
What is PHS 2015-02 / PA-15-270?
PHS 2015-02 refers to the NIH Omnibus Solicitation for Small Business Technology Transfer (STTR) Grant Applications, also described as the Parent STTR R41/R42 funding opportunity. It is a broad NIH funding opportunity (posted as PA-15-270 on grants.nih.gov) intended to support early-stage biomedical, behavioral, and health-related technology research and development by U.S. small businesses working in partnership with a U.S. research institution.
What is the main purpose of this STTR opportunity?
The purpose is to help U.S. small businesses move promising early-stage technologies from research into development through a structured collaboration with a U.S. research institution (such as a university, medical center, or nonprofit research organization). The underlying idea is to combine small business innovation with research-institution expertise, specialized equipment, and complementary capabilities to advance technologies toward real-world health impact.
Who is eligible to apply as the applicant organization?
The eligible applicant pool is limited to U.S. small business concerns. Foreign (non-U.S.) entities cannot apply as the small business applicant, and non-U.S. components of U.S. organizations are also not eligible to apply as the applicant.
Is a partnership required, and what kind of partner is expected?
Yes. This STTR opportunity is built around a structured partnership between the small business and a U.S. research institution. The description highlights universities, medical centers, and nonprofit research organizations as the types of institutions that often provide key expertise, specialized equipment, and capabilities that complement the small business.
What kinds of projects does NIH want to fund under this parent STTR solicitation?
The solicitation invites research and development projects that align with the missions of participating NIH Institutes and Centers. It is meant to be topic-flexible across NIH interests (rather than limited to a single disease area) as long as the proposal clearly matches an NIH awarding component's priorities. Examples of relevant projects include biomedical devices, diagnostics, therapeutics, digital health tools, research platforms, data resources, and other health-relevant technologies.
What does it mean that this is an "omnibus" or "parent" solicitation?
It means the opportunity is designed to be broadly applicable across NIH's missions and is not restricted to a narrow, single topic. Applicants are expected to make the alignment to a participating NIH Institute or Center explicit, but the overall solicitation is intentionally wide in scope.
What are the award phases and activity codes used in this program?
This opportunity uses the STTR phased award structure under activity codes R41 (Phase I) and R42 (Phase II).
What is typically supported in Phase I (R41)?
Phase I typically supports proof-of-concept work, feasibility studies, and initial prototype development. The goal is to demonstrate the approach is technically sound and worthy of further investment.
What is typically supported in Phase II (R42)?
Phase II generally supports more substantial development work that builds on successful Phase I results. Examples described include advanced prototyping, preclinical validation, further engineering, software development and testing, product refinement, and other steps needed to position the technology for commercialization or broader adoption.
Does NIH care only about scientific merit, or also about commercialization and real-world impact?
Based on the description, NIH is interested in both scientific merit and whether the work can realistically lead to a product, process, or service that improves human health. Applicants are expected to present an R&D plan with a clear pathway toward real-world impact, including commercialization or broader adoption where appropriate.
Are foreign organizations allowed to apply?
No. Foreign (non-U.S.) entities cannot apply as the small business applicant, and non-U.S. components of U.S. organizations are also not eligible to apply.
Can any part of the work be performed outside the United States?
The announcement notes that "foreign components," as NIH defines them in the NIH Grants Policy Statement, may be allowable in some cases. This suggests that certain parts of the work might be performed abroad if they meet NIH policy requirements and are well-justified.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
What type of funding instrument is used?
The funding instrument is a grant, categorized under discretionary funding.
What NIH topic areas or missions are included in the scope described?
The described scope is wide and reflected in associated CFDA program listings. Areas mentioned include (among others) environmental health; oral health; human genome research; deafness and communication disorders; complementary and integrative health; sleep disorders; mental health; alcohol and substance use; drug abuse and addiction; minority health and health disparities; translational sciences; research infrastructure; nursing research; multiple cancer research areas; cardiovascular, lung, and blood diseases; arthritis and musculoskeletal/skin diseases; diabetes, digestive, and kidney diseases; neuroscience and neurological disorders; allergy and infectious diseases; microbiology and infectious diseases; general biomedical research and training; child health and human development; aging; vision research; and medical library assistance.
Do applicants need to connect their proposal to a specific NIH Institute or Center?
Yes. The description indicates that proposals should match the missions of participating NIH Institutes and Centers, and that applicants should make that alignment explicit.
When was this funding opportunity posted, and what were the key dates?
The FOA was posted and created on June 4, 2015. The original and current closing date listed was April 5, 2016, and the archive date was May 6, 2016.
Is this opportunity still open?
No. The information provided indicates it is archived (archive date May 6, 2016), meaning it was active during the listed period and is no longer an open solicitation.
Where were applicants directed for the full official instructions?
Applicants were directed to the full announcement hosted by NIH on grants.nih.gov (the PA-15-270 page) for detailed instructions, requirements, and participating institute information.
Who is the contact for technical issues with the announcement link or access?
For technical issues accessing the full announcement or linking problems, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the overall takeaway for a small business considering this type of NIH STTR opportunity?
It functions as a centralized entry point for U.S. small businesses seeking NIH support to develop health-related technologies in collaboration with a research institution. The Phase I/Phase II STTR structure is intended to de-risk innovations through R&D while keeping a pathway to commercialization or deployment as an explicit long-term objective.
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