PHS 2016-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42]) | Apply Online

Opportunity Summary:

PHS 2016-02 is an NIH omnibus (broad, multi-topic) solicitation that supports Small Business Technology Transfer (STTR) grant applications under the Parent STTR mechanisms R41 (Phase I) and R42 (Phase II). The opportunity is run by the U.S. Department of Health and Human Services, National Institutes of Health (HHS-NIH), and it is designed specifically for eligible U.S. small business concerns that want to develop and translate innovations that align with NIH research and development priorities. In practical terms, this FOA is a front door into NIH-supported technology development for small companies that are prepared to do rigorous R and D and can connect their proposed work to one or more NIH Institute or Center missions and topic areas referenced in the associated PHS 2016-2 SBIR/STTR Program Descriptions and Research Topics.

The core purpose of the STTR program reflected in this announcement is to fund early-stage to mid-stage R and D that has clear potential for commercialization while also advancing biomedical and behavioral science. Unlike some small business programs that fund only internal company work, STTR is structured around a formal collaboration between a small business and a U.S. research institution (commonly a university, medical center, nonprofit research institute, or federally funded R and D center). The small business is the applicant and the primary awardee, but the research institution partner is an essential part of the model because STTR is meant to move promising science out of the research environment and into a development pathway that can lead to products, services, or platforms that improve health outcomes.

This specific solicitation is labeled a "parent" FOA, which generally indicates that it is not limited to a single disease area or one narrow technology type. Instead, it can cover a wide range of NIH-relevant projects as long as applicants anchor their proposal to the topics and program interests laid out in the NIH SBIR/STTR topic document referenced by the announcement. The activity categories listed for the opportunity span areas such as health (the central theme given NIH), but also intersect with education, environment, food and nutrition, income security, and social services, reflecting the broad ways NIH-supported innovations can touch public health and health-related systems.

From an administrative standpoint, the opportunity is classified as discretionary funding and uses the grant funding instrument. It was posted and created on June 3, 2016, under Funding Opportunity Number PA 16 303, with an original and current closing date of April 5, 2017. The eligible applicant type is small businesses, and the sponsoring agency is identified as HHS-NIH11. A long list of CFDA program numbers is associated with the solicitation, which signals that multiple NIH components and program areas can make awards under this umbrella announcement and that awards may be tracked under different NIH assistance listing categories depending on the Institute/Center and scientific area.

In terms of what an applicant is expected to do, the solicitation is aimed at small businesses that can demonstrate both technical capability and a credible development plan. Phase I (R41) is typically used to establish feasibility and generate key proof-of-concept data, reducing scientific and technical risk. Phase II (R42) is generally oriented toward full R and D efforts that build on Phase I results and move the technology closer to commercialization readiness, such as prototype refinement, validation studies, advanced testing, or other milestone-driven development work appropriate to the field. Because this is an NIH STTR parent opportunity, the proposed aims usually need to be framed in a way that clearly fits NIH priorities, articulates the unmet need, and shows how the innovation could realistically reach users or patients, whether through a regulated product pathway, adoption by healthcare systems, licensing, or other commercialization routes.

Overall, this FOA is best understood as a broad NIH funding channel for U.S. small businesses that are ready to partner with a research institution to develop NIH-relevant technologies. It supports the translation of scientific advances into real-world applications by funding structured, phased R and D projects that connect technical milestones to downstream commercial potential, while being flexible enough to encompass many research topics across the NIH landscape.

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