Opportunity Information: Apply for PA 12 157
Apply for PA 12 157
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Pilot and Feasibility Clinical Research Grants in Diabetes, and Endocrine and Metabolic Diseases (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Apr 6, 2015 and posted on Apr 10, 2012.
- Applicants must submit their applications by Apr 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: County governments For profit organizations other than small businesses Native American tribal governments (Federally recognized) Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Small businesses City or township governments Private institutions of higher education State governments Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply.Non domestic (non U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement , are allowed
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Opportunity Summary:
The Pilot and Feasibility Clinical Research Grants in Diabetes, and Endocrine and Metabolic Diseases (R21) opportunity (Funding Opportunity Number PA 12 157) is a discretionary grant program from the National Institutes of Health, specifically the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It is designed to support early stage, exploratory clinical and behavioral research projects that address the prevention or treatment of diabetes, endocrine disorders, and genetic metabolic diseases. The core purpose is to give investigators a practical way to test promising new ideas quickly, without being held back by the heavy preliminary data expectations that often come with larger, later phase clinical research awards.
The program emphasizes pilot and feasibility studies, meaning the proposed work should be short term and focused on answering a targeted clinical question that could realistically lead to meaningful improvements in patient care. Projects are expected to be exploratory in nature, such as trying out a new prevention approach, evaluating a novel intervention, or studying an innovative combination of therapies that has not been adequately tested in humans. Because these are pilot style R21 projects, the grant is meant to help generate the early evidence needed to justify a more definitive clinical trial or a larger, more comprehensive research program later on. The opportunity also explicitly values behavioral studies when they are clinically relevant, reflecting the reality that disease prevention and treatment often depend on adherence, lifestyle factors, health behaviors, and real world implementation challenges.
A major priority running through the announcement is translation, specifically moving strong scientific developments from the laboratory into clinical practice. In other words, NIDDK is looking for projects that help bridge the gap between promising mechanistic or preclinical findings and tangible clinical applications that could change how diabetes, endocrine diseases, or genetic metabolic diseases are prevented or treated. The scope includes cystic fibrosis within the broader category of genetic metabolic diseases noted in the description, signaling that clinically focused pilot work in that area may also be responsive when aligned with NIDDK interests.
From a funding standpoint, the award ceiling listed for this opportunity is $200,000, and there is no cost sharing or matching requirement. The funding instrument type is a grant, and the activity category is listed under food and nutrition/health within the broader NIH cataloging system, with CFDA number 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research). The opportunity was posted April 10, 2012, and the included timeline fields indicate closing dates in 2015 (with an archive date of May 7, 2015), which is useful context if someone is reviewing the announcement historically or looking for updated, active successors to this FOA.
Eligibility is broad and includes many types of applicant organizations. Eligible applicants listed include federal recognized tribal governments and other tribal organizations, state and local governments (including county, city, township, and special district governments), independent school districts, public housing authorities/Indian housing authorities, public and state controlled institutions of higher education, private institutions of higher education, nonprofit organizations (both 501(c)(3) and non 501(c)(3), excluding higher education institutions where specified), and for profit organizations other than small businesses, as well as small businesses. The announcement also highlights additional eligible applicant categories such as historically black colleges and universities (HBCUs), Hispanic serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, faith based or community based organizations, regional organizations, U.S. territories or possessions, and importantly, non U.S. (foreign) institutions. It also allows non U.S. components of U.S. organizations and foreign components as defined under the NIH Grants Policy Statement, which can matter for studies involving international populations, specialized sites, or unique expertise outside the United States.
For anyone seeking the complete official language, requirements, and NIH specific instructions tied to this R21 FOA, the full announcement is linked at http://grants.nih.gov/grants/guide/pa-files/PA-12-157.html. The contact information provided in the source text points applicants to the NIH Office of Extramural Research (OER) webmaster emails for technical access or linking problems, which is mainly administrative support rather than scientific program guidance.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled Pilot and Feasibility Clinical Research Grants in Diabetes, and Endocrine and Metabolic Diseases (R21).
What is the Funding Opportunity Number (FOA)?
The Funding Opportunity Number is PA-12-157.
Which agency and institute sponsor this opportunity?
This is a discretionary grant program from the National Institutes of Health (NIH), specifically the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
What is the main purpose of this R21 program?
The purpose is to support early-stage, exploratory clinical and behavioral research that addresses the prevention or treatment of diabetes, endocrine disorders, and genetic metabolic diseases. It is intended to let investigators test promising ideas quickly, without the heavy preliminary data expectations typical of larger, later-phase clinical research awards.
What kinds of studies does the program emphasize?
The program emphasizes pilot and feasibility studies. Proposed work should be short term, focused, and designed to answer a targeted clinical question that could realistically lead to meaningful improvements in patient care.
What types of projects are considered responsive or appropriate?
Projects are expected to be exploratory in nature, such as:
- Trying out a new prevention approach
- Evaluating a novel intervention
- Studying an innovative combination of therapies that has not been adequately tested in humans
Are behavioral research projects included?
Yes. The opportunity explicitly values behavioral studies when they are clinically relevant, recognizing the importance of adherence, lifestyle factors, health behaviors, and real-world implementation challenges in prevention and treatment.
What does "translation" mean in the context of this announcement?
A major priority is translation, meaning moving strong scientific developments from the laboratory into clinical practice. NIDDK is looking for projects that help bridge the gap between mechanistic or preclinical findings and tangible clinical applications that could change prevention or treatment.
Does the scope include cystic fibrosis?
Yes. The scope includes cystic fibrosis within the broader category of genetic metabolic diseases noted in the description, suggesting that clinically focused pilot work in that area may be responsive when aligned with NIDDK interests.
What is the maximum award amount listed for this opportunity?
The award ceiling listed is $200,000.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement listed.
What is the funding instrument type?
The funding instrument type is a grant.
How is this opportunity categorized in NIH systems?
The activity category is listed under food and nutrition/health within NIH cataloging, and the CFDA number is 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
When was this opportunity posted?
The opportunity was posted on April 10, 2012.
Is this FOA still active based on the dates provided?
The timeline fields included indicate closing dates in 2015, with an archive date of May 7, 2015. This is useful for historical reference or for identifying updated, active successor announcements.
Who is eligible to apply?
Eligibility is broad and includes many types of applicant organizations, including:
- Federally recognized tribal governments and other tribal organizations
- State governments
- Local governments (county, city, township, and special district governments)
- Independent school districts
- Public housing authorities/Indian housing authorities
- Public and state controlled institutions of higher education
- Private institutions of higher education
- Nonprofit organizations (501(c)(3) and non-501(c)(3), excluding higher education institutions where specified)
- For-profit organizations other than small businesses
- Small businesses
Are certain institution types specifically highlighted as eligible?
Yes. The announcement highlights additional eligible applicant categories such as:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian-serving institutions
- Faith-based or community-based organizations
- Regional organizations
- U.S. territories or possessions
Are non-U.S. (foreign) institutions eligible?
Yes. The eligible applicant list includes non-U.S. (foreign) institutions.
Can a U.S. organization include a non-U.S. component in the project?
Yes. The opportunity allows non-U.S. components of U.S. organizations and also foreign components as defined under the NIH Grants Policy Statement.
Why might foreign components matter for this FOA?
The text notes this can matter for studies involving international populations, specialized sites, or unique expertise outside the United States.
What is the intent of using an R21 mechanism for these projects?
Because these are pilot-style R21 projects, the grant is meant to help generate early evidence needed to justify a more definitive clinical trial or a larger, more comprehensive research program later on.
Where can applicants find the complete official announcement language and requirements?
The full announcement is available at: http://grants.nih.gov/grants/guide/pa-files/PA-12-157.html
What contact information is provided for help?
The contact information provided points to the NIH Office of Extramural Research (OER) webmaster emails for technical access or linking problems. This is described as administrative support rather than scientific program guidance.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 12 157) also looked into and applied for these:
| Funding Opportunity |
|---|
| Translational Research to Improve Obesity and Diabetes Outcomes (R18) Apply for PAR 12 172 Funding Number: PAR 12 172 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Planning Grants for Translational Research to Improve Obesity and Diabetes Outcomes (R34) Apply for PAR 12 173 Funding Number: PAR 12 173 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $150,000 |
| Promoting Organ and Tissue Donation Among Diverse Populations (R01) Apply for RFA DK 12 006 Funding Number: RFA DK 12 006 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $150,000 |
| Limited Competition for the Continuation of the Halt Polycystic Kidney Disease Trials Data Coordinating Center (DCC) (U01) Apply for RFA DK 12 505 Funding Number: RFA DK 12 505 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of Look AHEAD (Action for Health in Diabetes) Consortium (U01) Apply for RFA DK 12 502 Funding Number: RFA DK 12 502 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Renal Function and Chronic Kidney Disease in Aging (R01) Apply for PA 12 211 Funding Number: PA 12 211 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| George M. OBrien Kidney Research Core Centers (P30) Apply for RFA DK 12 008 Funding Number: RFA DK 12 008 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $750,000 |
| Research Enhancement for NIDDK Hematology Grantees (Admin Supp) Apply for PA 12 242 Funding Number: PA 12 242 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| New Technologies for the Study of Lymphatics in the Digestive and Urinary Systems (R43/R44) Apply for PA 12 258 Funding Number: PA 12 258 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $150,000 |
| Lymphatics in Health and Disease in the Digestive, Urinary, Cardiovascular and Pulmonary Systems (R01) Apply for PAR 12 259 Funding Number: PAR 12 259 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $250,000 |
| Lymphatics in Health and Disease in the Digestive, Cardiovascular and Pulmonary Systems (R21) Apply for PAR 12 260 Funding Number: PAR 12 260 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $125,000 |
| Ancillary Studies to Major Ongoing Clinical Research Studies to Advance Areas of Scientific Interest within the Mission of the NIDDK (R01) Apply for PAR 12 265 Funding Number: PAR 12 265 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Assessment, Serial Evaluation and Subsequent Sequelae of Acute Kidney Injury (ASSESS AKI) Study (U01) Apply for RFA DK 12 509 Funding Number: RFA DK 12 509 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Pilot Studies of Candidate Therapies for Chronic Kidney Disease (CKD) (U01) Apply for RFA DK 12 016 Funding Number: RFA DK 12 016 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Expansion of Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) (U01) Apply for RFA DK 12 017 Funding Number: RFA DK 12 017 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the Chronic Renal Insufficiency Cohort (CRIC) Study (U01) Apply for RFA DK 12 508 Funding Number: RFA DK 12 508 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Advancing Clinical Research in Primary Glomerular Diseases (UM1) Apply for RFA DK 12 014 Funding Number: RFA DK 12 014 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Novel Interventions to Reduce Morbidity and Mortality of Hemodialysis Patients Safety and Other Early Phase Studies (U01) Apply for RFA DK 12 010 Funding Number: RFA DK 12 010 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Multidisciplinary K12 Urologic Research (KURe) Career Development Program Apply for RFA DK 12 013 Funding Number: RFA DK 12 013 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $600,000 |
| Limited Competition Small Grant Program for NIDDK K01/K08/K23 Recipients (R03) Apply for PAR 12 285 Funding Number: PAR 12 285 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $50,000 |
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