Opportunity Information: Apply for PA 06 387
Apply for PA 06 387
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Pilot and Feasibility Clinical Research Grants in Diabetes, Endocrine and Metabolic Diseases (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Dec 5, 2008 and posted on May 5, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities For profit organizations other than small businesses Private institutions of higher education City or township governments Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education State governments County governments Native American tribal organizations (other than Federally recognized tribal governments).
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Pilot and Feasibility Clinical Research Grants in Diabetes, Endocrine and Metabolic Diseases (R21) opportunity (Funding Opportunity Number PA 06-387) is an NIH discretionary grant program run through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), specifically its Division of Diabetes, Endocrinology, and Metabolic Diseases. The program is built to fund short-term, early-stage clinical research that helps move promising ideas from the laboratory toward real-world clinical use. In practical terms, it supports pilot clinical studies as well as planning activities that make it possible to test whether a new concept, tool, or approach is ready for more definitive clinical trials later on.
The scientific focus is broad but clearly tied to NIDDKs mission areas in diabetes, endocrinology, and metabolism. The announcement emphasizes exploratory and developmental work that applies novel technologies, creates or refines research tools, develops biomarkers, builds new model systems, and tests innovative concepts with potential diagnostic or therapeutic value. Examples of included disease areas specifically named in the announcement include diabetes and its complications, obesity, endocrine disorders such as osteoporosis, and inborn errors of metabolism, with cystic fibrosis mentioned as a relevant example within that category. The overall theme is high-potential, translationally oriented clinical research that is still at a stage where feasibility, initial signals, and method development need to be established.
This opportunity uses the NIH R21 mechanism, which is meant for exploratory or early concept projects rather than large, mature programs of research. The idea is to give investigators room to pursue new directions, gather preliminary clinical data, validate an emerging biomarker, pilot a new diagnostic or therapeutic approach, or carry out the kind of planning and proof-of-concept work that reduces risk and supports future, larger-scale studies. Because R21 projects can vary widely in what they are trying to demonstrate, the program notes that award size and project structure may differ across funded applications, and the final number of awards depends on application quality, proposed duration, and budget.
The maximum project period is two years. Direct costs are capped at $275,000 total across the two-year project, and no more than $200,000 in direct costs may be requested in any single year. Budgets are submitted in modular format, in $25,000 modules, up to the total allowable direct-cost limit. A key constraint for planning purposes is that the R21 mechanism under this announcement is not renewable, so applicants should treat it as a one-time, time-limited award intended to generate momentum, feasibility evidence, and a strong foundation for subsequent grant applications rather than long-term program support.
Eligibility is broad and includes both U.S. and non-U.S. institutions. Eligible applicant organizations span for-profit and non-profit entities, public and private institutions such as universities, colleges, hospitals, and laboratories, and units of state and local government. Federal agencies may also apply, and the announcement explicitly includes Indian/Native American Tribal Governments (both federally recognized and other than federally recognized) and Indian/Native American tribally designated organizations. The provided eligibility notes also indicate that faith-based and community-based organizations may apply where appropriate. The opportunity listing further enumerates a wide range of applicant types, including public and state-controlled institutions of higher education, private institutions of higher education, various government entities (city/township, county, state, special district), public housing authorities/Indian housing authorities, independent school districts, and non-profits with or without 501(c)(3) status (with the stated caveat that some categories have exclusions or clarifications in the full announcement).
On the investigator side, the program is open to any individual with the skills, knowledge, and resources needed to carry out the proposed research, which aligns with standard NIH policy language encouraging broad participation. Multiple applications may be submitted by the same applicant as long as they are scientifically distinct, allowing teams to propose different pilot concepts rather than trying to force multiple aims into a single exploratory project.
From an administrative standpoint, the opportunity is categorized under Health, with CFDA number 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research). There is no cost-sharing or matching requirement. The announcement originally posted May 5, 2006, lists multiple receipt dates rather than a single deadline, with applicants directed to the full NIH program announcement for the specific schedule and instructions. The central purpose remains consistent throughout the document: to catalyze early clinical translation in diabetes, endocrine, and metabolic disease research by funding focused, time-limited pilot and feasibility efforts that can de-risk and accelerate the path to larger clinical studies.
FAQs: Pilot and Feasibility Clinical Research Grants in Diabetes, Endocrine and Metabolic Diseases (R21) (PA-06-387)
What is this grant opportunity?
This is the NIH Pilot and Feasibility Clinical Research Grants in Diabetes, Endocrine and Metabolic Diseases (R21) opportunity (Funding Opportunity Number PA 06-387). It is a discretionary grant program administered by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through its Division of Diabetes, Endocrinology, and Metabolic Diseases.
What is the main purpose of this program?
The program is designed to fund short-term, early-stage clinical research that helps move promising ideas from the laboratory toward real-world clinical use. It supports pilot clinical studies and planning or feasibility activities that determine whether a new concept, tool, or approach is ready for more definitive clinical trials later.
What type of research does it support?
It supports exploratory and developmental, translationally oriented clinical research. The emphasis is on work where feasibility, initial clinical signals, and method development still need to be established before larger studies can be justified.
What scientific areas are within scope?
The scope is broad but tied to NIDDK mission areas in diabetes, endocrinology, and metabolism. The announcement explicitly references diabetes (and its complications), obesity, endocrine disorders such as osteoporosis, and inborn errors of metabolism (with cystic fibrosis mentioned as a relevant example within that category).
What kinds of activities or outputs are emphasized?
The announcement emphasizes exploratory and developmental work that applies novel technologies, creates or refines research tools, develops biomarkers, builds new model systems, and tests innovative concepts with potential diagnostic or therapeutic value.
What does the R21 mechanism mean in this context?
The R21 is an NIH mechanism intended for exploratory or early concept projects rather than large, mature research programs. Under this opportunity, it is meant to give investigators room to pursue new directions, gather preliminary clinical data, validate an emerging biomarker, pilot a new diagnostic or therapeutic approach, or complete planning and proof-of-concept work that reduces risk for future larger-scale studies.
How long can the project last?
The maximum project period is two years.
What is the maximum budget allowed?
Direct costs are capped at $275,000 total across the two-year project period, and no more than $200,000 in direct costs may be requested in any single year.
How should the budget be submitted?
Budgets are submitted in modular format, using $25,000 modules, up to the total allowable direct-cost limit.
Is this award renewable?
No. The R21 mechanism under this announcement is not renewable. It is intended as a one-time, time-limited award to generate feasibility evidence and momentum for subsequent grant applications rather than long-term program support.
How many awards will be made?
The final number of awards depends on application quality, the proposed duration, and the budget. The announcement notes that award size and project structure may differ across funded applications.
Who is eligible to apply as an organization?
Eligibility is broad and includes both U.S. and non-U.S. institutions. Eligible applicant organizations include for-profit and non-profit entities and public and private institutions such as universities, colleges, hospitals, and laboratories, as well as units of state and local government.
Are federal agencies eligible to apply?
Yes. Federal agencies may apply under this opportunity.
Are Tribal governments and Tribal organizations eligible?
Yes. The announcement explicitly includes Indian/Native American Tribal Governments (federally recognized and other than federally recognized) and Indian/Native American tribally designated organizations.
Can faith-based or community-based organizations apply?
Yes. The eligibility notes indicate that faith-based and community-based organizations may apply where appropriate.
What other applicant organization types are specifically listed?
The opportunity listing enumerates a wide range of applicant types, including public and state-controlled institutions of higher education, private institutions of higher education, various government entities (city/township, county, state, special district), public housing authorities/Indian housing authorities, independent school districts, and non-profits with or without 501(c)(3) status (with the note that some categories may have exclusions or clarifications in the full announcement).
Who is eligible to serve as the project investigator?
Any individual with the skills, knowledge, and resources needed to carry out the proposed research may apply as an investigator. This follows standard NIH policy language encouraging broad participation.
Can an applicant submit more than one application?
Yes. Multiple applications may be submitted by the same applicant as long as they are scientifically distinct.
Is cost sharing or matching required?
No. There is no cost-sharing or matching requirement.
What is the CFDA number for this program?
The opportunity is listed under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
What is the general topic category for this opportunity?
The opportunity is categorized under Health.
When was the announcement posted?
The announcement was originally posted on May 5, 2006.
What are the application deadlines?
The announcement lists multiple receipt dates rather than a single deadline. Applicants are directed to the full NIH program announcement for the specific schedule and instructions.
What is the overall goal for applicants to keep in mind?
The central goal is to catalyze early clinical translation in diabetes, endocrine, and metabolic disease research by funding focused, time-limited pilot and feasibility efforts that de-risk and accelerate the path to larger clinical studies.
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