Opportunity Information: Apply for PAR 11 352
Apply for PAR 11 352
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Pilot and Feasibility Clinical Research Grants in Kidney or Urologic Diseases (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Mar 27, 2015 and posted on Sep 30, 2011.
- Applicants must submit their applications by Mar 27, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Public and State controlled institutions of higher education Small businesses County governments City or township governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) State governments Public housing authorities/Indian housing authorities Special district governments Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply.Non domestic (non U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Pilot and Feasibility Clinical Research Grants in Kidney or Urologic Diseases (R21) opportunity (Funding Opportunity Number PAR-11-352) is a National Institutes of Health program administered by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It is designed to fund early-stage, exploratory clinical and translational studies focused on kidney and urologic diseases. The intent is to help investigators generate the preliminary human data, operational experience, and proof-of-concept evidence needed to justify and successfully launch larger, definitive clinical research efforts later on. In practice, this means the program targets smaller, well-justified projects that can answer high-value clinical questions or test promising approaches in a way that is realistic within a limited budget and timeframe.
The scope of projects emphasized in this announcement includes small-scale clinical and translational studies, and it explicitly allows epidemiological studies and clinical trials when they are appropriate for a pilot or feasibility format. Proposed studies are expected to focus on important clinical and translational questions and to have clear potential for meaningful clinical or public health impact. A central theme is feasibility: projects should help determine whether an approach is workable, whether recruitment and retention are achievable, whether outcome measures perform as expected, whether a diagnostic strategy is practical in real-world settings, or whether there are early signals that justify scaling up. NIDDK also signals that many successful R21 projects are expected to become stepping-stones to full-scale research, such as larger epidemiologic investigations, development and validation of diagnostic strategies, or randomized clinical trials addressing diagnosis, prevention, or treatment in kidney or urologic conditions.
This is an R21 Exploratory/Developmental Research Grant, which generally aligns with NIH’s goal for the mechanism: supporting innovative, early-stage work where substantial preliminary data may not yet exist, but where the idea is compelling and the study can produce actionable next-step evidence. The award information in the source data lists an award ceiling of $200,000, reinforcing that the program is meant for focused pilot efforts rather than large, multi-year definitive trials. There is no cost-sharing or matching requirement, which lowers the barrier for organizations that may not have the ability or desire to commit non-federal funds.
Eligibility is broad and includes many types of domestic U.S. organizations as well as foreign institutions. Eligible applicants include public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations other than small businesses, small businesses, independent school districts, and multiple levels of government (city/township, county, state), plus special district governments and public housing authorities/Indian housing authorities. The announcement also highlights eligibility for a range of mission-driven and capacity-building institutions and organizations, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities, and other tribal organizations and regional organizations. Faith-based and community-based organizations are included as eligible applicants as well. For international participation, non-U.S. entities (foreign institutions) may apply, non-U.S. components of U.S. organizations are eligible, and foreign components as defined by the NIH Grants Policy Statement are allowed, which can be important for studies involving international cohorts, specialized expertise, or unique populations.
From a program positioning standpoint, this FOA sits within NIH’s broader extramural research portfolio under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research). While the activity category in the listing is labeled under broader health-related classifications, the scientific emphasis is clearly centered on kidney and urologic disease clinical and translational research. The anticipated outcome is not simply publication, but the de-risking of larger clinical research investments by producing concrete feasibility metrics, refined protocols, early safety or performance signals, and the groundwork needed to compete for subsequent larger grants or to mount full-scale clinical studies.
Administratively, the opportunity was posted September 30, 2011, and the listing shows a lifecycle that includes an original closing date of January 7, 2015, a current closing date of March 27, 2015, and an archive date of April 27, 2015, indicating that this specific announcement is no longer open. The full announcement was made available through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PAR-11-352.html, and the contact information provided routes technical access or linking issues to the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the Pilot and Feasibility Clinical Research Grants in Kidney or Urologic Diseases (R21) opportunity?
It is an NIH funding opportunity (Funding Opportunity Number PAR-11-352) administered by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It supports early-stage, exploratory clinical and translational research focused on kidney and urologic diseases, with an emphasis on pilot and feasibility work.
What is the main goal of this program?
The program is intended to help investigators generate preliminary human data, operational experience, and proof-of-concept evidence. The aim is to produce practical next-step evidence that can justify and support later, larger, definitive clinical research efforts.
What NIH grant mechanism is used for this opportunity?
This opportunity uses the R21 Exploratory/Developmental Research Grant mechanism, which is commonly used for innovative, early-stage work where substantial preliminary data may not yet exist, but the concept is strong and the project can produce actionable evidence.
What kinds of studies are emphasized under this FOA?
The scope emphasizes small-scale clinical and translational studies in kidney and urologic diseases. The announcement explicitly allows epidemiological studies and clinical trials when they fit a pilot or feasibility format.
Are clinical trials allowed under this opportunity?
Yes. Clinical trials are explicitly allowed when they are appropriate for a pilot or feasibility study.
Are epidemiological studies allowed under this opportunity?
Yes. Epidemiological studies are explicitly allowed when they are appropriate for a pilot or feasibility format.
What does "pilot" or "feasibility" mean in this program context?
It means the proposed project should be smaller in scale and designed to answer whether a larger study is workable. Examples include assessing whether recruitment and retention are achievable, whether outcome measures perform as expected, whether a diagnostic strategy is practical in real-world settings, or whether there are early signals that justify scaling up to a larger study.
What types of questions should proposed projects address?
Projects are expected to focus on important clinical and translational questions in kidney and urologic diseases and to show clear potential for meaningful clinical or public health impact, while remaining realistic within the limited budget and timeframe typical of an R21 pilot effort.
How is this funding opportunity positioned as a stepping-stone to larger projects?
NIDDK indicates that many successful R21 projects are expected to serve as stepping-stones to full-scale research efforts, such as larger epidemiologic investigations, development and validation of diagnostic strategies, or randomized clinical trials addressing diagnosis, prevention, or treatment in kidney or urologic conditions.
What is the maximum award amount listed in the source information?
The source information lists an award ceiling of $200,000, reinforcing that the program is intended for focused pilot and feasibility projects rather than large, definitive trials.
Is cost-sharing or matching required?
No. The opportunity states there is no cost-sharing or matching requirement.
Who can apply (in general terms)?
Eligibility is broad and includes many types of domestic U.S. organizations as well as foreign institutions. Eligible applicants include institutions of higher education, nonprofit organizations, for-profit organizations (other than small businesses are listed as eligible, and small businesses are also listed), independent school districts, and various levels of government.
What types of U.S. organizations are eligible to apply?
Eligible U.S. applicants include public and private institutions of higher education; nonprofits (including 501(c)(3) and non-501(c)(3) organizations); for-profit organizations; small businesses; independent school districts; city/township, county, and state governments; special district governments; and public housing authorities/Indian housing authorities.
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are included as eligible applicants.
Are Historically Black Colleges and Universities (HBCUs) eligible?
Yes. The announcement highlights eligibility for Historically Black Colleges and Universities (HBCUs).
Are Hispanic-serving Institutions eligible?
Yes. The announcement highlights eligibility for Hispanic-serving Institutions.
Are Alaska Native and Native Hawaiian Serving Institutions eligible?
Yes. The announcement highlights eligibility for Alaska Native and Native Hawaiian Serving Institutions.
Are Tribally Controlled Colleges and Universities and other tribal organizations eligible?
Yes. The announcement highlights eligibility for Tribally Controlled Colleges and Universities, other tribal organizations, and regional organizations.
Can foreign institutions apply?
Yes. Non-U.S. entities (foreign institutions) may apply.
Are non-U.S. components of U.S. organizations eligible?
Yes. Non-U.S. components of U.S. organizations are eligible.
Are foreign components allowed as part of an application?
Yes. Foreign components (as defined by the NIH Grants Policy Statement) are allowed, which can support work involving international cohorts, specialized expertise, or unique populations.
Which NIH institute administers this opportunity?
The program is administered by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) within the National Institutes of Health (NIH).
What is the CFDA number associated with this opportunity in the source information?
The source information places the opportunity within NIH’s extramural research portfolio under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
Is this specific announcement still open for applications?
No. The listing indicates the opportunity is no longer open. It shows a current closing date of March 27, 2015 and an archive date of April 27, 2015.
What are the key dates shown in the listing?
The opportunity was posted on September 30, 2011. The listing shows an original closing date of January 7, 2015, a current closing date of March 27, 2015, and an archive date of April 27, 2015.
Where can the full FOA text be found?
The full announcement was made available through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PAR-11-352.html.
Who is the contact for technical access or linking issues related to the announcement listing?
The contact provided for technical access or linking issues is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What kinds of outcomes does NIDDK appear to value from these projects?
Beyond publication, the emphasis is on de-risking later larger clinical research investments by producing concrete feasibility metrics, refined protocols, early safety or performance signals, and other groundwork that strengthens future applications for larger grants or full-scale clinical studies.
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