Pilot and Feasibility Clinical Research Grants in Kidney or Urologic Diseases (R21) | Apply Online

Opportunity Summary:

The Pilot and Feasibility Clinical Research Grants in Kidney or Urologic Diseases (R21) funding opportunity (PAR-09-077) is a National Institutes of Health program issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to support early-stage, small-scale clinical and translational studies focused on kidney and urologic diseases. The central aim is to help researchers test promising ideas quickly and efficiently through pilot or feasibility work that answers important clinical or translational questions and has the potential to lead to meaningful improvements in patient care or public health. The program explicitly welcomes projects that may be exploratory in nature but are still grounded in clinical relevance, such as studies that evaluate new approaches to diagnosis, prevention, or treatment, or that clarify disease patterns and outcomes in patient populations.

This opportunity uses the NIH Exploratory/Developmental Research Grant mechanism (R21), which is designed for projects that are not yet ready for a large, definitive clinical study but have strong rationale and clear potential. In practice, that means applicants are expected to propose focused research that can generate key preliminary data, demonstrate feasibility of recruitment and procedures, refine an intervention or diagnostic strategy, validate outcome measures, or identify signals that justify a subsequent larger-scale investigation. The announcement notes that some funded projects are anticipated to evolve into full-scale clinical efforts, including larger epidemiological studies, diagnostic strategy studies, or randomized clinical trials aimed at diagnosing, preventing, or treating kidney or urologic diseases.

The types of studies encouraged include clinical and translational research broadly, and it specifically mentions epidemiological studies and clinical trials as examples of allowable research directions, as long as they remain within a pilot or feasibility scope consistent with the R21 mechanism. The emphasis is on studies that can have high clinical and public health impact, meaning reviewers will likely prioritize proposals that address significant disease burdens, unmet clinical needs, or clear gaps in current practice, and that can plausibly inform the next steps toward larger trials or implementation-focused research.

From an administrative and funding perspective, awards under this FOA are contingent on the availability of funds and the receipt of a sufficient number of meritorious applications, which is standard NIH language indicating that funding decisions depend on both budget and application quality. The listed award ceiling is $200,000. The program is categorized as a discretionary grant opportunity, and it is associated with CFDA number 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research). There is no cost sharing or matching requirement, so applicants are not required to contribute non-federal funds as a condition of the award.

Eligibility is broad and includes many types of organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, for-profit entities (including small businesses and other for-profits), and a wide range of government bodies such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also allows participation from tribal governments and tribal organizations, including federally recognized tribal governments as well as other tribal entities. In addition, it explicitly includes organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. Notably, non-U.S. entities (foreign organizations) are also listed as eligible, which can be important for international clinical or epidemiological work relevant to kidney or urologic disease.

Key dates provided indicate the opportunity was posted on January 14, 2009, with an original and current closing date of January 7, 2012, and an archive date of February 7, 2012. That means this particular announcement is no longer active as written, but it remains useful as a description of the kind of pilot and feasibility kidney/urologic clinical research NIDDK has sought to stimulate under the R21 mechanism. For applicants seeking current opportunities, the archived FOA can serve as a template for understanding NIH expectations, while a live NIH listing would be needed for up-to-date submission dates and current policy requirements.

For additional details, the FOA points to the NIH Grants Guide webpage associated with PAR-09-077. The contact information provided is primarily technical support through the NIH Office of Extramural Research (OER) webmaster for access or linking issues, rather than a scientific or grants management program contact.

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