Opportunity Information: Apply for PA 12 171
Apply for PA 12 171
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Pilot and Feasibility Studies in Preparation for Drug and Alcohol Abuse Prevention Trials (R34)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Apr 7, 2015 and posted on Apr 23, 2012.
- Applicants must submit their applications by Apr 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $225,000.00 in funding.
- Eligible applicants include: Independent school districts For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Special district governments City or township governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education State governments Small businesses Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply.Non domestic (non U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Pilot and Feasibility Studies in Preparation for Drug and Alcohol Abuse Prevention Trials (R34) funding opportunity (PA 12-171) is a National Institutes of Health (NIH) discretionary grant program designed to help researchers generate the early evidence needed to move prevention ideas into full-scale trials. The central purpose is to fund pilot and feasibility work for preventive interventions that aim to stop or delay the start of drug and alcohol use, prevent escalation from initial use to abuse or dependence, and reduce risks related to HIV acquisition or transmission when those risks are connected to drug or alcohol use. The emphasis is on testing whether a prevention approach is practical, acceptable, and promising enough to justify a larger, more definitive prevention study later on.
This R34 opportunity focuses on two main kinds of projects. First, it supports pilot and feasibility testing of new, revised, or adapted prevention interventions. That includes interventions tailored for different populations, cultures, age groups, or real-world settings, as long as the work is aimed at substance use initiation, progression to more serious use problems, or substance-related HIV prevention. Second, it supports pre-trial feasibility testing for prevention services and systems research, meaning studies that look at how prevention services can be delivered, implemented, supported, or scaled within organizations and service systems. In both cases, the goal is to produce data that make a future, larger prevention trial scientifically and operationally realistic.
A key boundary in this announcement is what it does not fund. The R34 mechanism here is not intended for developing intervention protocols from scratch, writing manuals, or standardizing protocols as a primary deliverable. In other words, the work should not be centered on creating the basic paperwork or formal documentation of an intervention. Instead, the expectation is that applicants are ready to test a prevention strategy in an early-stage way and to collect data that demonstrate feasibility and generate initial signals of efficacy, effectiveness, or service-delivery impact. NIH frames this as early-stage efficacy, effectiveness, or services research that will serve as the prerequisite foundation for submitting a subsequent, larger grant application for a full prevention intervention study related to drug/alcohol abuse and/or drug/alcohol-related HIV prevention.
The practical outcome NIH is looking for from an R34 project is strong pilot evidence that reduces uncertainty before a larger trial. That typically means answering questions like: Can you recruit and retain the intended participants in the targeted setting? Will participants and providers accept the intervention? Can the intervention be delivered with reasonable fidelity, cost, and staffing? Do the measures and data collection procedures work as planned? Are there early indications that the intervention influences relevant prevention outcomes, such as delaying initiation, reducing risky patterns of use, preventing progression toward disorder, or reducing HIV-related risk behaviors linked to substance use? The program is meant to de-risk the next step so that a later large-scale trial is based on real operational experience rather than assumptions.
In terms of administrative details from the listing, this is a grant (FundingInstrumentType: Grant) in the education and health activity areas, with CFDA numbers 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs). The award ceiling listed is $225,000, and there is no cost sharing or matching requirement. The opportunity was posted on April 23, 2012, with later record updates reflected in the creation date of April 7, 2015. The original closing date shown is May 7, 2015, and the record indicates it was archived May 7, 2015, which means this specific posting is no longer active, although similar NIH R34 opportunities may appear in later years under new announcements.
Eligibility is broad and includes many organization types across the public, private, and nonprofit sectors. Eligible applicants include state, county, city or township governments; independent school districts; special district governments; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with and without 501(c)(3) status (with the noted exclusions related to institutions of higher education); for-profit organizations other than small businesses; and small businesses. The eligibility information also highlights additional eligible applicants such as faith-based or community-based organizations; federally recognized tribal governments and other tribal organizations; tribally controlled colleges and universities (TCCUs); historically Black colleges and universities (HBCUs); Hispanic-serving institutions; Alaska Native and Native Hawaiian-serving institutions; regional organizations; eligible federal agencies; and U.S. territories or possessions. Importantly, non-U.S. entities (foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by NIH policy, which signals that NIH is open to prevention research in diverse international contexts where scientifically justified.
For applicants looking to use this mechanism strategically, the most aligned projects are those that already have a reasonably specified intervention concept and are ready to test it in a targeted population or setting, while still needing pilot data to justify a larger trial. The strongest fit is usually a study that is explicit about what feasibility questions will be answered, what minimum benchmarks will indicate readiness for a subsequent trial, and how the pilot findings will directly inform the design of the later, larger prevention study. The full announcement was linked through NIH at http://grants.nih.gov/grants/guide/pa-files/PA-12-171.html, and NIH’s Office of Extramural Research (OER) webmaster contact was provided for access or linking issues.
Frequently Asked Questions (FAQs)
What is the Pilot and Feasibility Studies in Preparation for Drug and Alcohol Abuse Prevention Trials (R34) opportunity?
This opportunity (PA 12-171) is an NIH discretionary grant program that funds pilot and feasibility studies to generate early evidence needed to move prevention ideas into full-scale trials. The aim is to test whether a prevention approach is practical, acceptable, and promising enough to justify a larger, more definitive prevention study later on.
What is the main purpose of this R34 program?
The central purpose is to support early-stage research that reduces uncertainty before launching a larger prevention trial. Projects are expected to produce pilot evidence about feasibility and early signals of efficacy, effectiveness, or service-delivery impact related to drug/alcohol abuse prevention and/or drug/alcohol-related HIV risk prevention.
What prevention outcomes is NIH trying to impact through this program?
The program focuses on preventive interventions intended to: (1) stop or delay initiation of drug and alcohol use, (2) prevent escalation from initial use to abuse or dependence, and (3) reduce risks related to HIV acquisition or transmission when those risks are connected to drug or alcohol use.
What kinds of projects does this R34 support?
This R34 focuses on two main project types: (1) pilot and feasibility testing of new, revised, or adapted prevention interventions, including tailoring for different populations, cultures, age groups, or real-world settings; and (2) pre-trial feasibility testing for prevention services and systems research, examining how prevention services can be delivered, implemented, supported, or scaled within organizations and service systems.
What does "pilot and feasibility testing" mean in this context?
In this context, pilot and feasibility testing refers to early-stage studies designed to determine whether a prevention approach can realistically be carried out and studied as planned. Typical questions include whether participants can be recruited and retained, whether the intervention is acceptable to participants and providers, whether it can be delivered with reasonable fidelity and resources, and whether measures and data collection procedures work as intended.
Does this opportunity support adapting an intervention for a new population or setting?
Yes. The announcement explicitly includes pilot and feasibility testing of interventions that are adapted or tailored for different populations, cultures, age groups, or real-world settings, as long as the work targets substance use initiation, progression to more serious use problems, or substance-related HIV prevention.
What is meant by "prevention services and systems research" under this R34?
Prevention services and systems research refers to studies that evaluate feasibility prior to a full trial by examining how prevention services can be delivered, implemented, supported, or scaled within organizations and service systems. The emphasis is on making a later, larger prevention trial scientifically and operationally realistic.
What is specifically not funded under this R34 announcement?
This R34 is not intended for developing intervention protocols from scratch, writing manuals, or standardizing protocols as a primary deliverable. Projects should not be centered on creating basic paperwork or formal documentation of an intervention. Instead, NIH expects applicants to be ready to test a prevention strategy and collect feasibility data and early outcome signals.
Is this grant meant to fund a full-scale prevention trial?
No. This mechanism is intended to generate pilot and feasibility evidence that serves as the prerequisite foundation for a later, larger grant application for a full prevention intervention study.
What types of evidence or results is NIH looking for from an R34 project?
NIH is looking for strong pilot evidence that reduces uncertainty before a larger trial. Examples include evidence that recruitment and retention are achievable, the intervention is acceptable, delivery can be done with reasonable fidelity/cost/staffing, measurement and data collection procedures function as planned, and there are early indications of impact on relevant prevention outcomes (such as delaying initiation, reducing risky use patterns, preventing progression toward disorder, or reducing HIV risk behaviors linked to substance use).
How does this R34 "de-risk" a later large-scale trial?
The program aims to ensure that the next step (a larger trial) is based on real operational experience rather than assumptions. By answering practical feasibility questions and generating early signals of impact, the pilot study reduces scientific and operational uncertainty for a subsequent definitive trial.
What is the funding instrument type for this opportunity?
The listing identifies the FundingInstrumentType as a Grant.
What activity areas does this grant fall under?
The listing places the opportunity in the education and health activity areas.
What are the CFDA numbers associated with this opportunity?
The CFDA numbers listed are 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs).
What is the award ceiling for this opportunity?
The award ceiling listed is $225,000.
Is cost sharing or matching required?
No. The listing states there is no cost sharing or matching requirement.
When was this opportunity posted and when did it close?
The opportunity was posted on April 23, 2012. The original closing date shown is May 7, 2015.
Is this specific funding opportunity still active?
No. The record indicates it was archived on May 7, 2015, meaning this specific posting is no longer active (even though similar NIH R34 opportunities may be released later under new announcements).
Who is eligible to apply?
Eligibility is broad and includes organizations across the public, private, and nonprofit sectors. Eligible applicants listed include state, county, city or township governments; independent school districts; special district governments; public housing authorities/Indian housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with and without 501(c)(3) status (with noted exclusions related to institutions of higher education); for-profit organizations other than small businesses; and small businesses.
Are tribal entities and specialized institutions eligible?
Yes. The eligibility information highlights federally recognized tribal governments and other tribal organizations, tribally controlled colleges and universities (TCCUs), historically Black colleges and universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Are faith-based or community-based organizations eligible?
Yes. The eligibility information explicitly includes faith-based or community-based organizations.
Can non-U.S. (foreign) organizations apply?
Yes. The eligibility information states that non-U.S. entities (foreign institutions) are eligible to apply. It also states that non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by NIH policy.
What kinds of applicants are the best strategic fit for this mechanism?
The most aligned projects are those with a reasonably specified intervention concept that is ready for early-stage testing in a targeted population or setting, but that still needs pilot data to justify a larger trial. The strongest fit is typically a study that clearly states the feasibility questions to be answered, the benchmarks indicating readiness for a subsequent trial, and how the pilot findings will inform the design of the later, larger prevention study.
Where can applicants find the full announcement?
The full announcement was linked through NIH at: http://grants.nih.gov/grants/guide/pa-files/PA-12-171.html
Who was listed as the contact for access or linking issues?
The NIH Office of Extramural Research (OER) webmaster contact was provided for access or linking issues.
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Applicants also applied for:
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| Pre Application for the FY13 NIDA Avant Garde Award Program for HIV/AIDS Research (X02) Apply for PAR 12 164 Funding Number: PAR 12 164 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| FY13 NIDA Avant Garde Award Program for HIV/AIDS Research (DP1) Apply for RFA DA 13 002 Funding Number: RFA DA 13 002 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Identifying Health Outcomes Associated with Changes in Use of Illicit Drugs (R01) Apply for RFA DA 13 007 Funding Number: RFA DA 13 007 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Synthesis and Preclinical Evaluation of Medications to Treat Substance Use Disorders (SUDs) (R01) Apply for RFA DA 13 004 Funding Number: RFA DA 13 004 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Innovative Health Information Technology for Broad Adoption by Healthcare Systems and Consumers (SBIR) (R44) Apply for PA 12 196 Funding Number: PA 12 196 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Community Clinical Oncology Program Groups (U10) Apply for RFA CA 12 007 Funding Number: RFA CA 12 007 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Minority Based Community Clinical Oncology Program Groups (U10) Apply for RFA CA 12 008 Funding Number: RFA CA 12 008 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NIMH Career Transition Award for Tenure Track and Tenured Intramural Investigators (K22) Apply for PAR 12 201 Funding Number: PAR 12 201 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Research Education Grants for Statistical and Computational Training in the Genetics of Addiction (R25) Apply for PAR 12 199 Funding Number: PAR 12 199 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| U.S. India Bilateral Collaborative Research Partnerships (CRP) on the Prevention of HIV/AIDS and Co morbidities (R21) Apply for RFA AI 12 033 Funding Number: RFA AI 12 033 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Establish Sharing of Human Brain Image Data Relevant to Drug Addiction (Admin Supp) Apply for PAR 12 204 Funding Number: PAR 12 204 Agency: National Institutes of Health Category: Education Health Funding Amount: $100,000 |
| Advancing Exceptional Research on HIV/AIDS (R01) Apply for RFA DA 13 008 Funding Number: RFA DA 13 008 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Identifying Non coding RNA Targets for Early Detection of Cancer (R01) Apply for PA 12 213 Funding Number: PA 12 213 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Identifying Non coding RNA Targets for Early Detection of Cancer (R21) Apply for PA 12 214 Funding Number: PA 12 214 Agency: National Institutes of Health Category: Education Health Funding Amount: $275,000 |
| Biomarkers for Early Detection of Hematopoietic Malignancies (R21) Apply for PA 12 220 Funding Number: PA 12 220 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Biomarkers for Early Detection of Hematopoietic Malignancies (R01) Apply for PA 12 221 Funding Number: PA 12 221 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Cohort Studies of HIV/AIDS and Substance Use (U01) Apply for PAR 12 222 Funding Number: PAR 12 222 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Advancing Community level Approaches to Reduce HIV Infection in Highly Impacted Communities (R01) Apply for RFA MH 13 090 Funding Number: RFA MH 13 090 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Advancing Community level Approaches to Reduce HIV Infection in Highly Impacted Communities (R21) Apply for RFA MH 13 091 Funding Number: RFA MH 13 091 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Advancing Community level Approaches to Reduce HIV Infection in Highly Impacted Communities (R34) Apply for RFA MH 13 092 Funding Number: RFA MH 13 092 Agency: National Institutes of Health Category: Education Health Funding Amount: $225,000 |
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