Opportunity Information: Apply for PA 08 208

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Pilot studies in Pancreatic Cancer (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.399 Cancer Control.
  • This funding opportunity was created on Dec 5, 2008 and posted on Jul 18, 2008.
  • Applicants must submit their applications by Sep 7, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: Small businesses For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) State governments Public and State controlled institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
  • Other Eligible Applicants include the following Eligible Agencies of the Federal Government Hispanic serving Institutions Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations U.S. Territory or Possession.
Apply for PA 08 208

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Opportunity Summary:

The "Pilot studies in Pancreatic Cancer (R21)" opportunity (Funding Opportunity Number PA-08-208) is a National Cancer Institute (NCI), NIH funding announcement designed to push forward early-stage, innovative pancreatic cancer research. The central aim is to support exploratory or developmental projects that can open up new directions or generate strong preliminary data in areas that matter most to pancreatic cancer outcomes, including the cancer's underlying biology, what causes it (etiology), how it can be detected earlier or more accurately, and how it can be prevented or treated more effectively. A major emphasis is on work that brings together multiple disciplines, reflecting the idea that meaningful progress in pancreatic cancer often depends on combining expertise across fields rather than staying within a single research lane.

The award uses the NIH R21 mechanism, which is specifically meant for pilot and exploratory studies that may be higher-risk or less mature than a typical full research project, but potentially high-impact if successful. In practical terms, this mechanism supports the kind of research that can test a new concept, develop a novel tool or approach, or produce proof-of-principle evidence that later justifies a larger, more definitive grant. This FOA is also described as running in parallel with a companion announcement of the same scientific scope, PA-08-209, which uses the R03 mechanism. That parallel structure signals that applicants with smaller, more limited-scope projects may have an alternative route (R03), while projects needing the exploratory/developmental scale typical of an R21 can use PA-08-208.

Financially, the listed award ceiling is $200,000, and there is no cost sharing or matching requirement, meaning applicants are not required to provide additional non-federal funds to secure the award. The number of awards was not predetermined; awards depend on how much funding is available and how many applications are both submitted and judged to be highly meritorious. The opportunity is categorized as a discretionary grant and is associated with several CFDA numbers tied to cancer research areas: cancer cause and prevention (93.393), detection and diagnosis (93.394), treatment (93.395), biology (93.396), and cancer control (93.399). This range reinforces that the program is intentionally broad, covering the full continuum from understanding disease mechanisms through to improving patient-centered outcomes.

Eligibility is expansive and includes many organization types. Eligible applicants include small businesses, other for-profit organizations, state governments, public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (both those with 501(c)(3) status and certain nonprofits without that status, with a noted exception/clarification in the full eligibility text). The announcement also explicitly includes additional eligible applicants such as federal agencies, Hispanic-serving institutions, non-U.S. entities (foreign organizations), regional organizations, and U.S. territories or possessions. This wide eligibility scope suggests NCI was aiming to attract a diverse pipeline of ideas and to allow strong pancreatic cancer concepts to compete regardless of whether they originate in academia, government, nonprofit research, or industry.

Key administrative details place this as a time-limited, archived opportunity. It was posted July 18, 2008, created December 5, 2008, with an original and current closing date of September 7, 2011, and an archive date of October 8, 2011. In other words, the announcement itself is no longer open, but it provides a clear snapshot of the type of exploratory pancreatic cancer research NCI was seeking under the R21 framework at that time. For the complete archived announcement, the source link is provided (http://grants.nih.gov/grants/guide/pa-files/PA-08-208.html), and technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contact listed in the notice.

FAQs: Pilot Studies in Pancreatic Cancer (R21) - PA-08-208

What is the "Pilot studies in Pancreatic Cancer (R21)" opportunity?

It is a National Cancer Institute (NCI), NIH funding announcement intended to advance early-stage, innovative pancreatic cancer research through pilot and exploratory projects. The Funding Opportunity Number is PA-08-208.

What is the main purpose of PA-08-208?

The central aim is to support exploratory or developmental studies that can open new research directions or generate strong preliminary data in pancreatic cancer. The announcement emphasizes early-stage, potentially high-impact work that may be higher-risk than traditional, more mature research projects.

What types of research areas does this opportunity emphasize?

The opportunity targets areas that directly affect pancreatic cancer outcomes, including:

  • Underlying biology of pancreatic cancer
  • Etiology (what causes pancreatic cancer)
  • Earlier or more accurate detection
  • Prevention approaches
  • More effective treatments

Does the announcement encourage multidisciplinary research?

Yes. A major emphasis is on research that brings together multiple disciplines, reflecting the idea that meaningful progress in pancreatic cancer often depends on combining expertise across fields rather than remaining within a single discipline.

What grant mechanism does PA-08-208 use?

It uses the NIH R21 mechanism, which is designed for pilot and exploratory studies. R21 projects are often less mature, potentially higher-risk, and aimed at developing new concepts, tools, approaches, or proof-of-principle evidence that could support a later, larger grant.

What kinds of projects are a good fit for an R21 under this opportunity?

Based on the description, good-fit projects include exploratory or developmental efforts such as testing a new idea, developing a novel tool or approach, or generating proof-of-principle and preliminary data to justify a larger study later.

Is there a related or companion funding opportunity?

Yes. PA-08-208 is described as running in parallel with a companion announcement, PA-08-209, with the same scientific scope but using the R03 mechanism. The parallel structure suggests R03 may be an alternative for smaller, more limited-scope projects.

What is the funding limit (award ceiling) for this opportunity?

The listed award ceiling is $200,000.

Is cost sharing or matching required?

No. There is no cost sharing or matching requirement, meaning applicants are not required to provide additional non-federal funds to receive the award.

How many awards were expected to be made?

The number of awards was not predetermined. Awards depended on available funding and on the number of applications submitted and judged to be highly meritorious.

How is this opportunity categorized?

It is categorized as a discretionary grant.

Which CFDA numbers are associated with this announcement?

The announcement is associated with multiple CFDA numbers covering a broad set of cancer research areas:

  • 93.393 (cancer cause and prevention)
  • 93.394 (detection and diagnosis)
  • 93.395 (treatment)
  • 93.396 (biology)
  • 93.399 (cancer control)

What does the range of CFDA numbers suggest about scope?

It indicates the program was intentionally broad and aimed to cover the full continuum from understanding disease mechanisms to improving outcomes, including prevention, detection/diagnosis, treatment, biology, and cancer control.

Who is eligible to apply?

Eligibility is expansive and includes a wide range of organization types, including:

  • Small businesses
  • Other for-profit organizations
  • State governments
  • Public and state-controlled institutions of higher education
  • Private institutions of higher education
  • Nonprofit organizations (including 501(c)(3) nonprofits and certain nonprofits without 501(c)(3) status, with an exception/clarification referenced in the full eligibility text)
  • Federal agencies
  • Hispanic-serving institutions
  • Non-U.S. entities (foreign organizations)
  • Regional organizations
  • U.S. territories or possessions

Are foreign organizations eligible?

Yes. The eligibility language explicitly includes non-U.S. entities (foreign organizations).

Are federal agencies eligible to apply?

Yes. The announcement explicitly includes federal agencies among eligible applicants.

Is this funding opportunity still open?

No. It is a time-limited, archived opportunity. The closing date was September 7, 2011, and the archive date was October 8, 2011.

When was the opportunity posted and created?

It was posted on July 18, 2008, and created on December 5, 2008.

Where can the complete archived announcement be found?

The archived announcement is available at: http://grants.nih.gov/grants/guide/pa-files/PA-08-208.html

Who was listed for technical access issues related to the announcement?

Technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contact listed in the notice.

What is the basic takeaway about what NCI was trying to fund through PA-08-208?

NCI was aiming to attract a diverse set of innovative, early-stage pancreatic cancer ideas from many types of organizations, with a strong preference for exploratory, potentially high-impact pilot studies and for projects that integrate multiple disciplines.

Browse more opportunities from the same agency: National Institutes of Health

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Previous opportunity: Investigations on Primary Immunodeficiency Diseases (R01)

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