Opportunity Information: Apply for RFA AG 14 017

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Planning Grants for Alzheimers Disease Translational Centers for Predictive Drug Development (R34)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
  • This funding opportunity was created on Mar 6, 2014 and posted on Mar 6, 2014.
  • Applicants must submit their applications by May 15, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: Small businesses City or township governments Public housing authorities/Indian housing authorities Private institutions of higher education For profit organizations other than small businesses County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) State governments Special district governments Native American tribal governments (Federally recognized).
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The funding opportunity titled "Planning Grants for Alzheimers Disease Translational Centers for Predictive Drug Development (R34)" (Funding Opportunity Number RFA-AG-14-017) is a discretionary NIH grant program issued by the National Institutes of Health, specifically aligned with the National Institute on Aging (NIA) mission area of aging research (CFDA 93.866). Its central goal is not to fund a full translational center outright, but to provide short-term planning support so that prospective applicant teams can organize, coordinate, and strengthen the groundwork needed to submit a competitive full application under NIA's Alzheimers Disease Translational Centers for Predictive Drug Development (ADCPD) initiative. In practical terms, this R34 mechanism is meant to help institutions and collaborations use a defined planning period to clarify the scientific vision, assemble the right expertise and partnerships, and develop the operational and administrative structure required for a larger center-style effort focused on predictive drug development for Alzheimer's disease.

This opportunity uses the NIH "Grant" funding instrument type and is structured as a planning grant (R34), which typically supports activities such as feasibility assessments, consortium formation, protocol and pipeline planning, governance design, milestone setting, and other preparatory steps that make a later, more resource-intensive center proposal realistic and well-justified. The emphasis in the announcement is on readiness-building for an ADCPD submission, which implies applicants are expected to spend the planning period defining how their proposed translational center would function, what capabilities it would integrate, and how it would pursue predictive approaches that improve the odds that candidate therapeutics will succeed in later-stage development. Rather than primarily producing new discovery data, the intended output is a well-developed, implementable plan that can be translated into a strong full application.

From a funding perspective, NIH estimated total funding for the announcement at $1,500,000, with an award ceiling of $200,000. There is no cost sharing or matching requirement, which reduces barriers for applicants and makes the budget more straightforward, especially for planning-focused work that is often difficult to co-finance. The FOA was posted and created on March 6, 2014, with an original and current closing date of May 15, 2014, and an archive date of June 15, 2014, indicating it was a time-limited solicitation with a single main submission window.

Eligibility is broad and intentionally inclusive, reflecting the cross-sector nature of translational drug development and the value of diverse institutional capabilities. Eligible applicants include small businesses, other for-profit organizations, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), private and public institutions of higher education, and a wide range of government entities including city or township governments, county governments, state governments, independent school districts, special district governments, and public housing authorities/Indian housing authorities. The announcement also lists multiple categories of additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, regional organizations, and eligible federal agencies. Native American tribal governments (federally recognized) and other tribal organizations are included. At the same time, the FOA is clear that non-U.S. (foreign) institutions are not eligible to apply as applicant organizations, and non-U.S. components of U.S. organizations are not eligible. However, foreign components are allowed under NIH policy definitions, which can enable discrete international collaborations or contributions when justified and consistent with NIH Grants Policy Statement rules.

Operationally, applicants were directed to the full announcement via the NIH Guide for Grants and Contracts link provided in the FOA (http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-14-017.html). The contact information included the NIH Office of Extramural Research (OER) Webmaster addresses for technical issues accessing the announcement or resolving linking problems, indicating that the primary support listed in the excerpt is technical rather than programmatic. Overall, the program can be understood as a targeted planning investment: NIH and NIA used this R34 FOA to help prospective Alzheimer's translational center teams build credible, detailed, and coordinated proposals that could later compete for ADCPD center funding focused on predictive drug development.

FAQs: Planning Grants for Alzheimers Disease Translational Centers for Predictive Drug Development (R34)

What is the title and funding opportunity number for this grant?

The opportunity is titled "Planning Grants for Alzheimers Disease Translational Centers for Predictive Drug Development (R34)" and the Funding Opportunity Number is RFA-AG-14-017.

Which federal agency and NIH institute are associated with this opportunity?

This is a discretionary NIH grant program issued by the National Institutes of Health (NIH) and aligned with the National Institute on Aging (NIA) mission area of aging research.

What is the CFDA number tied to this opportunity?

The CFDA number listed for this opportunity is 93.866.

What type of funding instrument is used?

The funding instrument type is "Grant."

What kind of grant mechanism is this (and what does R34 mean here)?

This opportunity uses the NIH R34 planning grant mechanism. In this context, the R34 is meant to provide short-term planning support rather than full funding for a complete translational center.

What is the main purpose of this R34 funding opportunity?

The central goal is to fund planning activities that help prospective applicant teams organize, coordinate, and strengthen the groundwork needed to submit a competitive full application under NIA's Alzheimers Disease Translational Centers for Predictive Drug Development (ADCPD) initiative.

Is this opportunity intended to fund a full translational center?

No. The FOA emphasizes that it is not intended to fund a full translational center outright. It is intended to support planning and readiness-building so a strong, full center-style application can be developed later under the ADCPD initiative.

What kinds of activities are typically supported under this planning grant?

The FOA describes planning-focused activities such as feasibility assessments, consortium formation, protocol and pipeline planning, governance design, milestone setting, and other preparatory steps that make a later, more resource-intensive center proposal realistic and well-justified.

What kinds of outputs are expected from the planning period?

The emphasis is on producing a well-developed, implementable plan for a future ADCPD submission. The intended output is planning and operational readiness (for example, a clarified scientific vision, assembled expertise and partnerships, and a defined operational/administrative structure), rather than primarily generating new discovery data.

How does this opportunity relate to predictive drug development for Alzheimers disease?

The planning period is intended to help teams define how a proposed translational center would function and how it would pursue predictive approaches aimed at improving the odds that candidate therapeutics will succeed in later-stage development for Alzheimers disease.

What is the total estimated funding available for this announcement?

NIH estimated total funding for the announcement at $1,500,000.

What is the maximum award amount (award ceiling)?

The award ceiling listed in the FOA is $200,000.

Is cost sharing or matching required?

No. The FOA states there is no cost sharing or matching requirement.

When was this funding opportunity posted and created?

The FOA was posted and created on March 6, 2014.

What were the closing date and archive date?

The original and current closing date was May 15, 2014, and the archive date was June 15, 2014. This indicates it was a time-limited solicitation with a single main submission window.

Who is eligible to apply?

Eligibility is broad. Eligible applicants include small businesses, other for-profit organizations, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), private and public institutions of higher education, and various government entities (including city or township governments, county governments, state governments, independent school districts, special district governments, and public housing authorities/Indian housing authorities).

Are minority-serving institutions and similar organizations listed as eligible?

Yes. The FOA lists additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).

Are tribal governments and tribal organizations eligible?

Yes. Native American tribal governments (federally recognized) and other tribal organizations are included in the eligible applicant types.

Are faith-based, community-based, or regional organizations eligible?

Yes. The FOA includes faith-based or community-based organizations and regional organizations among eligible applicant categories.

Are federal agencies eligible to apply?

Yes. The FOA includes eligible federal agencies among eligible applicant categories.

Can a non-U.S. (foreign) institution apply as the applicant organization?

No. The FOA states that non-U.S. (foreign) institutions are not eligible to apply as applicant organizations.

Are non-U.S. components of U.S. organizations eligible?

No. The FOA states that non-U.S. components of U.S. organizations are not eligible.

Are foreign components allowed in any form?

Yes. The FOA notes that foreign components are allowed under NIH policy definitions, which can enable discrete international collaborations or contributions when justified and consistent with NIH Grants Policy Statement rules.

Where can applicants find the full announcement?

Applicants were directed to the full announcement in the NIH Guide for Grants and Contracts at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-14-017.html

What contact information is provided for help with access or technical issues?

The excerpt lists the NIH Office of Extramural Research (OER) Webmaster addresses for technical issues accessing the announcement or resolving linking problems, indicating the primary support in the excerpt is technical rather than programmatic.

In plain terms, what is NIH/NIA trying to accomplish with this FOA?

This FOA is a targeted planning investment intended to help prospective Alzheimers translational center teams build credible, detailed, and coordinated proposals that could later compete for ADCPD center funding focused on predictive drug development.

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