PPHF 2015 Enhanced Surveillance for New Vaccine Preventable Disease A Program Expansion for Acute | Apply Online

Opportunity Summary:

The grant opportunity titled "PPHF 2015 Enhanced Surveillance for New Vaccine Preventable Disease - A Program Expansion for Acute" (Funding Opportunity Number RFA IP 11 0100501PPHF15) is a CDC cooperative agreement designed to expand and strengthen hospital-based surveillance for pediatric acute respiratory illness. The program is framed as supplemental funding to support a coordinated network of U.S. pediatric institutions that can generate reliable, comparable data across multiple sites. Its central public health goal is to improve understanding of how well influenza vaccines protect children from severe disease requiring hospitalization, while also building capacity to monitor other major viral threats that cause similar respiratory illness in children.

The primary purpose is to assess influenza vaccine effectiveness (VE) against laboratory-confirmed influenza among hospitalized children. In practical terms, this means participating hospitals would enroll pediatric inpatients with acute respiratory illness, test them for influenza using laboratory methods, and then evaluate whether vaccinated children are less likely to have confirmed influenza compared with unvaccinated children, accounting for relevant clinical and epidemiologic factors. The emphasis on laboratory confirmation is important because it moves beyond diagnosis codes or symptoms alone, reducing misclassification and making VE estimates more defensible for policy and clinical decision-making. By focusing on hospitalized children, the project concentrates on the more severe end of the disease spectrum, which is often the most consequential for health systems and prevention strategies.

A second, explicitly stated purpose is to establish an inpatient surveillance network capable of monitoring key non-influenza viral pathogens associated with pediatric acute respiratory illness, specifically including respiratory syncytial virus (RSV) and enterovirus D68 (EV-D68). This reflects the reality that children hospitalized with respiratory symptoms may be infected with a range of viruses that can surge unpredictably and place heavy burden on pediatric care. Building inpatient surveillance for these pathogens helps public health partners understand seasonality, geographic spread, and disease severity, and it supports earlier detection of unusual activity. The announcement indicates attention to pediatric populations, with influenza VE work focused on hospitalized children age 18 years and the non-influenza surveillance component including children age 5 years, consistent with the stated target age groups in the source description.

Operationally, this opportunity is categorized as discretionary funding and uses a cooperative agreement mechanism, meaning CDC would be expected to have substantial involvement in the project beyond simple pass-through funding. Cooperative agreements typically involve collaboration on surveillance approaches, data standards, reporting timelines, and potentially analytic methods, which is especially relevant when multiple institutions are expected to function as a single network. The activity category is health, and the program anticipates making up to 7 awards. The estimated total funding amount is $3,500,000, and there is no cost-sharing or matching requirement. The funding listing provides award floor and ceiling as $0, which often indicates the specific award amounts are determined by CDC based on the supplemental scope, available funds, and negotiated budgets rather than being constrained by a preset cap in the summary.

Eligibility is limited and highly specific: only the following organizations are listed as eligible applicants, indicating this was intended as a targeted expansion for an existing or previously selected network rather than an open competition. The eligible institutions are Vanderbilt University School of Medicine (Nashville, TN), University of Rochester School of Medicine and Dentistry (Rochester, NY), Cincinnati Childrens Hospital Medical Center (Cincinnati, OH), Texas Childrens Hospital (Houston, TX), Seattle Childrens Hospital (Seattle, WA), Childrens Mercy Hospital and Clinics (Kansas City, MO), and Childrens Hospital and Research Center (Oakland, CA). These sites collectively represent a geographically diverse set of major pediatric centers, which supports the broader surveillance goal of capturing variation across regions and influenza seasons.

Key administrative details place the opportunity in 2015: it was posted and created on March 24, 2015, with an original and current closing date of May 26, 2015, and an archive date of June 25, 2015. The sponsoring agency is the Centers for Disease Control and Prevention. For applicants or stakeholders needing help accessing the full announcement, CDC listed the Technical Information Management Section (TIMS) as the point of contact, with mailing address in Atlanta, GA, phone and fax numbers, and the email PGOTIM@cdc.gov.

Overall, this supplemental award opportunity is best understood as a focused CDC effort to strengthen a pediatric inpatient respiratory surveillance network with two linked deliverables: robust, multi-site estimates of influenza vaccine effectiveness against lab-confirmed influenza hospitalizations in children, and an enhanced hospital-based surveillance capability for other high-impact respiratory viruses such as RSV and EV-D68. By combining vaccine effectiveness evaluation with broader pathogen surveillance in hospitalized children, the program supports both near-term situational awareness and longer-term evidence needed to guide vaccination strategy, preparedness, and clinical and public health response.

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