Pre application for a Biomedical Technology Research Center (X02) | Apply Online

Opportunity Summary:

This opportunity, PAR 10 224, is a National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) from the National Center for Research Resources that invites organizations to submit a pre-application for a new national Biomedical Technology Research Center (BTRC) using the X02 mechanism. The basic idea is that NIH wants to identify strong prospective Center concepts before applicants invest the time and effort required for a full Center proposal. These BTRCs are meant to be national resources that develop and advance biomedical technologies and instruments that are directly motivated by real needs in basic science, translational research, and clinical research. In other words, the Center is not just doing science for its own sake; it is expected to build enabling technologies and improved tools that other researchers can use to push their work forward.

A key point is that this X02 announcement does not itself provide funding. No formal awards will be made under PAR 10 224, and there is no stated pool of funds or number of awards anticipated because the outcome is not a grant. Instead, the pre-application functions as a screening step. Applicants whose pre-applications are judged to be meritorious and programmatically relevant will be notified that they are eligible to move forward by submitting a full BTRC application under the related FOA, PAR 10 225, which uses the P41 mechanism. Because the pre-application and full application are linked, applicants are expected to read and follow both FOAs, with PAR 10 225 providing the detailed description of the required components and expectations for an actual BTRC.

In terms of what NIH is looking for in a BTRC concept, the Centers are expected to do more than develop new tools in-house. They have explicit responsibilities to operate as community-facing resources: making their technologies available to outside investigators, training members of the broader research community to use the technologies effectively, and disseminating both the technologies and the experimental results broadly. That dissemination mission is central to the BTRC model, since these Centers are intended to have national reach and impact rather than serving only a single institution or a small group of collaborators.

This pre-application step is specifically for applicants proposing a new Center. Existing BTRCs are not required to submit a pre-application under this FOA, which implies they would follow different instructions or processes when competing for continuation or renewal under the applicable full-application announcements. The purpose here is to help NIH manage the pipeline for new Centers by encouraging early concept review and ensuring proposed efforts align with NIH program priorities before a full-scale P41 submission.

Eligibility is broad and includes many common NIH applicant categories. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, state governments, and nonprofit organizations (including both 501(c)(3) and nonprofits without 501(c)(3) status, other than institutions of higher education). The FOA also explicitly calls out additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and eligible federal agencies. There is no cost sharing or matching requirement.

From an administrative standpoint, the opportunity is classified as a discretionary grant program within education and health-related activity categories, and it lists CFDA numbers 93.389 (National Center for Research Resources) and 93.859 (Biomedical Research and Research Training). The FOA was posted June 30, 2010, with an original and current closing date of December 13, 2012, and it was archived January 13, 2013. The full announcement was hosted by NIH at the link provided in the notice, and the contact information directs applicants with access or linking problems to the NIH Office of Extramural Research webmaster email.

Overall, PAR 10 224 is best understood as an entry gate to the full P41 BTRC competition: it invites a concise, early-stage pre-application describing a proposed national technology Center, emphasizing technology development driven by researcher needs plus strong plans for access, training, and dissemination. A positive response to the pre-application does not provide funding, but it is the pathway NIH uses to invite selected applicants to submit a full-scale P41 application for a new Biomedical Technology Research Center under PAR 10 225.

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