Opportunity Information: Apply for RFA HL 15 025
Apply for RFA HL 15 025
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Pre Symptomatic Profiles of Chronic Lung Disease(s) from Retrospective Cohorts (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research.
- This funding opportunity was created on Oct 2, 2014 and posted on Oct 2, 2014.
- Applicants must submit their applications by Jan 21, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,640,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Independent school districts City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Special district governments Small businesses Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments State governments Public and State controlled institutions of higher education Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity "Pre Symptomatic Profiles of Chronic Lung Disease(s) from Retrospective Cohorts (R21)" (Funding Opportunity Number RFA-HL-15-025) is an NIH discretionary research grant designed to push the field toward earlier identification of chronic lung diseases, before people develop clear symptoms or receive a formal diagnosis. The central idea is to use existing clinical research datasets and cohorts that have already collected health information over time, and then perform secondary analyses to test creative, well-justified hypotheses about how chronic lung disease begins and evolves. Rather than funding brand-new data collection, the program is meant to extract new scientific value from data that already exist, using modern analytic approaches to detect early patterns that could signal future disease.
A core emphasis of the announcement is on the epidemiology of incident chronic lung disease(s), meaning the focus is on new onset disease and the lead-up to it, not just describing established disease. Applicants are expected to analyze retrospective cohort data in a way that can reveal pre-symptomatic clinical profiles and, where available, biological phenotypes. In practical terms, this can include identifying early changes in lung function trajectories, subtle symptom patterns that precede diagnosis, early imaging signals, biomarker trends, environmental or occupational exposure signatures, comorbidity patterns, medication histories, or gene-environment interactions that become apparent only when datasets are analyzed with the explicit goal of characterizing the pre-disease window.
The program is positioned as a stepping-stone toward primary prevention research. By defining and validating pre-symptomatic phenotypes and risk profiles, the resulting findings are intended to serve as preliminary data that can justify later, larger applications aimed at preventing disease onset in at-risk individuals. In other words, the R21 mechanism here is being used to encourage high-impact, hypothesis-driven discovery from existing data, with the expectation that successful projects will clarify who is at risk, what early measurable signals matter, and when intervention opportunities might exist before irreversible lung damage or chronic symptoms set in.
From a funding and administrative standpoint, this is an NIH grant in the health category with an expected six awards and an estimated total funding amount of $2,640,000. The award ceiling is listed as $275,000. There is no cost sharing or matching requirement. The opportunity was posted on October 2, 2014, with an original and final closing date of January 21, 2015, and it was archived on February 21, 2015. While the dates indicate this specific announcement is historical, the summary still reflects the structure and intent of the opportunity as it was published.
Eligibility is broad and spans a wide range of organizations that can manage NIH grants. Eligible applicants include nonprofit organizations (both with and without 501(c)(3) status, excluding institutions of higher education in that specific phrasing), for-profit organizations other than small businesses, small businesses, public and private institutions of higher education, independent school districts, and multiple levels of government including city/township, county, state, special district governments, and public housing authorities/Indian housing authorities. The eligibility language also explicitly includes various mission-focused institution types and community-centered entities such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and eligible federal agencies. Tribal governments, including federally recognized tribal governments and other tribal government entities, are included as eligible applicants. Foreign organizations and foreign institutions are not eligible to apply directly, but non-U.S. components of U.S. organizations are allowed, and foreign components are permitted under NIH policy definitions, which can matter for projects that rely on international collaborators, expertise, or specific analytic contributions while keeping the applicant organization U.S.-based.
The sponsoring agency is the National Institutes of Health, and the opportunity is tied to CFDA 93.838 (Lung Diseases Research), signaling its alignment with NIH investments in understanding and ultimately reducing the burden of lung disease. The full announcement was made available through the NIH Grants Guide at the provided link, and NIH Office of Extramural Research support contacts were listed for access or linking issues.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Pre Symptomatic Profiles of Chronic Lung Disease(s) from Retrospective Cohorts (R21)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-HL-15-025.
Who is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH).
What type of grant mechanism is this?
This is an NIH discretionary research grant using the R21 mechanism.
What is the main purpose of this funding opportunity?
The main purpose is to push the field toward earlier identification of chronic lung diseases by analyzing the period before people develop clear symptoms or receive a formal diagnosis, using existing clinical research datasets and cohorts.
Does this opportunity fund new data collection?
No. The program is intended to extract new scientific value from data that already exist, rather than funding brand-new data collection.
What kind of research approach is emphasized?
The announcement emphasizes secondary analyses of existing retrospective cohort data to test creative, well-justified, hypothesis-driven ideas about how chronic lung disease begins and evolves.
What does "retrospective cohorts" mean in the context of this opportunity?
It refers to existing cohorts and clinical research datasets that have already collected health information over time, which applicants can use for secondary analyses.
What is meant by "pre-symptomatic profiles" in this announcement?
It refers to clinical profiles (and where available, biological phenotypes) that can be detected before obvious symptoms appear or before a formal diagnosis is made.
Is the focus on people with established chronic lung disease?
No. A core emphasis is the epidemiology of incident chronic lung disease(s), meaning the focus is on new onset disease and what happens leading up to it, rather than only describing established disease.
What kinds of signals or variables could be analyzed to identify pre-symptomatic disease?
Examples described include early changes in lung function trajectories, subtle symptom patterns that precede diagnosis, early imaging signals, biomarker trends, environmental or occupational exposure signatures, comorbidity patterns, medication histories, and gene-environment interactions.
Are biological phenotypes required?
The announcement expects applicants to reveal pre-symptomatic clinical profiles and, where available, biological phenotypes. This indicates biological phenotypes are included when the cohort/dataset contains them.
What is the ultimate longer-term research direction this program is trying to support?
The program is positioned as a stepping-stone toward primary prevention research by defining and validating pre-symptomatic phenotypes and risk profiles that can support later, larger applications aimed at preventing disease onset in at-risk individuals.
How many awards were expected under this opportunity?
The opportunity anticipated approximately six awards.
What was the estimated total funding amount?
The estimated total funding amount was $2,640,000.
What is the award ceiling listed for this opportunity?
The award ceiling is listed as $275,000.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement stated for this opportunity.
When was this opportunity posted?
It was posted on October 2, 2014.
What were the closing dates for applications?
The original closing date and the final closing date were both January 21, 2015.
Is this opportunity still open?
No. It was archived on February 21, 2015, and the dates indicate it is a historical announcement.
What is the CFDA number associated with this opportunity?
The opportunity is tied to CFDA 93.838, Lung Diseases Research.
What general topic area/category does this opportunity fall under?
It is an NIH grant in the health category focused on chronic lung disease research, particularly early identification and pre-symptomatic profiling.
What types of organizations are eligible to apply?
Eligibility is broad and includes nonprofit organizations (with and without 501(c)(3) status, excluding institutions of higher education in that specific phrasing), for-profit organizations other than small businesses, small businesses, public and private institutions of higher education, independent school districts, and multiple levels of government (city/township, county, state, special district governments, and public housing authorities/Indian housing authorities).
Are minority-serving institutions explicitly included in eligibility?
Yes. The eligibility language explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly included as eligible applicants.
Are tribal governments eligible to apply?
Yes. Tribal governments, including federally recognized tribal governments and other tribal government entities, are included as eligible applicants.
Are foreign organizations eligible to apply directly?
No. Foreign organizations and foreign institutions are not eligible to apply directly.
Can a U.S.-based applicant include non-U.S. components or foreign components?
Yes. Non-U.S. components of U.S. organizations are allowed, and foreign components are permitted under NIH policy definitions, which can be relevant for projects involving international collaborators or analytic contributions while keeping the applicant organization U.S.-based.
Where was the full announcement made available?
The full announcement was made available through the NIH Grants Guide (via the link referenced in the opportunity description).
Who was listed for support if there were access or linking issues?
NIH Office of Extramural Research support contacts were listed for access or linking issues.
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