Opportunity Information: Apply for RFA DA 11 014
Apply for RFA DA 11 014
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Predictive Animal Models for Smoking Cessation Medications (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Feb 4, 2011 and posted on Feb 4, 2011.
- Applicants must submit their applications by Mar 31, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Private institutions of higher education For profit organizations other than small businesses Independent school districts Public and State controlled institutions of higher education City or township governments State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Predictive Animal Models for Smoking Cessation Medications (U54) opportunity (Funding Opportunity Number RFA-DA-11-014) was a National Institutes of Health program led by the National Institute on Drug Abuse (NIDA) to support a coordinated, multi-project research effort aimed at strengthening the preclinical pipeline for smoking cessation treatments. Rather than funding a single, stand-alone research project, the FOA called for an integrated program designed to develop, refine, and validate a weighted battery of animal behavioral assays that could better predict which candidate medications are likely to help people stop smoking. The central idea was to move beyond any single animal test and instead assemble a set of complementary behavioral measures, with defined weighting, that together provide more reliable and decision-ready evidence for advancing (or deprioritizing) medication candidates before costly clinical trials.
This was offered as a cooperative agreement (U54), meaning awardees would be expected to work in close coordination with NIH/NIDA, consistent with the cooperative mechanism where the agency typically has substantial scientific involvement during the conduct of the program. The activity area was listed under Education and Health, and it fell under CFDA 93.279, Drug Abuse and Addiction Research Programs. Cost sharing or matching was not required, which generally lowers the barrier for applicants by keeping the project budget responsibility focused on the federal award rather than institutional contributions.
The FOA was posted on February 4, 2011, with an original and final closing date of March 31, 2011, and it was archived on May 1, 2011. NIH estimated total funding at $2,500,000, reflecting a relatively targeted funding pool intended to support one or more substantial programmatic awards rather than a broad set of smaller grants. Because the goal was a “multi project research program,” applicants were expected to propose a structured set of interlocking projects and cores typical of U54 programs, such as multiple research components and shared resources for coordination, data management, assay standardization, and administrative oversight.
Eligibility was broad and included many organizational types across the public, private, nonprofit, and tribal sectors. Eligible applicants included state and local governments (state governments, county governments, city or township governments, and special district governments), public and private institutions of higher education (including public/state-controlled universities and private universities), nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions when specified), for-profit organizations (including small businesses and other for-profit entities), independent school districts, and public housing authorities/Indian housing authorities. The FOA also explicitly recognized additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), federally recognized tribal governments, other Indian/Native American tribal governments, regional organizations, U.S. territories or possessions, faith-based or community-based organizations, and eligible federal agencies. This wide eligibility aligns with the translational nature of the work, which can involve academic behavioral pharmacology, specialized animal model development, and potentially industry-aligned drug development expertise.
In practical terms, the work supported by this FOA would have focused on building a more predictive set of animal behavioral tests relevant to tobacco dependence and smoking cessation. “Weighted battery” implies that the program was expected not only to compile multiple assays but also to determine how much each assay should count in an overall decision framework, likely based on sensitivity, specificity, reproducibility across labs, and alignment with known clinical outcomes for existing cessation therapies. The intended product of the program was a preclinical testing approach that could be used more confidently to prioritize candidate medications, improve go/no-go decisions, and ultimately increase the efficiency and success rate of translating promising mechanisms into effective cessation treatments.
Administrative details in the announcement pointed applicants to the full FOA text via an NIH grants guide link (http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-11-014.html). For technical access issues, the contact provided was the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV), which is typical for archived or electronically hosted federal funding announcements.
FAQs: Predictive Animal Models for Smoking Cessation Medications (U54) (RFA-DA-11-014)
What is this funding opportunity?
This opportunity is the NIH program titled "Predictive Animal Models for Smoking Cessation Medications (U54)," Funding Opportunity Number RFA-DA-11-014. It was led by the National Institute on Drug Abuse (NIDA) and aimed to support a coordinated, multi-project research effort to strengthen the preclinical pipeline for smoking cessation treatments.
What is the main goal of the program?
The program goal was to develop, refine, and validate a weighted battery of animal behavioral assays that could better predict which candidate medications are likely to help people stop smoking. The intent was to improve preclinical decision-making before moving candidates into expensive clinical trials.
What does "multi-project research program" mean in this context?
Rather than funding a single stand-alone study, the FOA called for an integrated program made up of multiple interlocking projects and shared cores. This structure is typical of U54 programs and commonly includes several research components plus shared resources for coordination, standardization, data management, and administration.
What does "weighted battery of animal behavioral assays" mean?
Why did the FOA emphasize moving beyond a single animal test?
The central idea was that no single animal behavioral assay is expected to be sufficiently predictive on its own. By combining multiple complementary measures with defined weighting, the program aimed to produce a more reliable approach for go/no-go decisions about advancing medication candidates.
What type of award mechanism was used?
This FOA used a cooperative agreement mechanism (U54). Under a cooperative agreement, awardees are expected to work in close coordination with NIH/NIDA, and the agency typically has substantial scientific involvement during the conduct of the program.
Which NIH institute led this program?
The program was led by the National Institute on Drug Abuse (NIDA), which is part of the National Institutes of Health (NIH).
What activity area and CFDA listing did this opportunity fall under?
The activity area was listed under Education and Health. The opportunity fell under CFDA 93.279, "Drug Abuse and Addiction Research Programs."
Was cost sharing or matching required?
No. The FOA stated that cost sharing or matching was not required.
How much total funding was NIH estimating for this opportunity?
NIH estimated total funding at $2,500,000, indicating a targeted pool intended to support one or more substantial programmatic awards rather than many smaller grants.
When was the FOA posted and when did it close?
The FOA was posted on February 4, 2011. The original and final closing date was March 31, 2011.
Is this funding opportunity still open?
No. The FOA was archived on May 1, 2011, and the final closing date was March 31, 2011.
Where could applicants find the full FOA text?
The announcement directed applicants to the full FOA text via the NIH Grants Guide link: http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-11-014.html
Who was eligible to apply?
Eligibility was broad and included many organizational types across public, private, nonprofit, and tribal sectors. Examples listed in the FOA summary include state and local governments, public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses), independent school districts, public housing authorities/Indian housing authorities, and additional categories such as certain minority-serving institutions, tribal governments, regional organizations, U.S. territories or possessions, faith-based or community-based organizations, eligible federal agencies, and more.
Were tribal entities and tribal-serving organizations included in eligibility?
Yes. The FOA explicitly recognized federally recognized tribal governments, other Indian/Native American tribal governments, Tribally Controlled Colleges and Universities (TCCUs), and other related categories.
Were minority-serving institutions included in eligibility?
Yes. The FOA summary explicitly listed Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs) among eligible categories.
Could for-profit organizations apply?
Yes. The eligibility list included for-profit organizations, including small businesses and other for-profit entities.
Could government entities apply?
Yes. The eligibility list included state governments, county governments, city or township governments, special district governments, and also referenced eligible federal agencies.
What kinds of components were applicants expected to propose in a U54 program?
Because the FOA called for a multi-project research program, applicants were expected to propose a structured set of interlocking projects and cores typical of U54 programs. Examples noted include multiple research components and shared resources for coordination, data management, assay standardization, and administrative oversight.
What was the intended practical outcome of the supported work?
The intended product was a more predictive preclinical testing approach for tobacco dependence and smoking cessation, enabling more confident prioritization of candidate medications, improved go/no-go decisions, and greater efficiency in translating promising mechanisms into effective cessation treatments.
How was the "weighting" of assays expected to be determined?
Based on the FOA description, weighting implied the program would determine how much each assay should count in an overall decision framework. The summary notes that this would likely be informed by factors such as sensitivity, specificity, reproducibility across labs, and alignment with known clinical outcomes for existing cessation therapies.
What kind of research focus did the FOA support?
The focus was on preclinical animal behavioral tests relevant to tobacco dependence and smoking cessation, with an emphasis on developing and validating a set of assays that together predict clinical potential better than any single assay alone.
What does "strengthening the preclinical pipeline" mean here?
In this FOA, it refers to improving the quality and reliability of preclinical evidence used to decide which candidate smoking cessation medications should move forward (or be deprioritized) before entering costly clinical trials.
Who should be contacted for technical access issues related to the FOA link?
For technical access issues, the contact provided was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the Funding Opportunity Number for this program?
The Funding Opportunity Number is RFA-DA-11-014.
What is the award type associated with the U54 mechanism?
The U54 mechanism is a cooperative agreement, which generally indicates substantial NIH scientific involvement and close coordination between the awardees and the agency during the program.
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