Opportunity Information: Apply for RFA AI 11 033
Apply for RFA AI 11 033
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Predictive Biodosimetry Discovery and Development of Biomarkers for Acute and Delayed Radiation Injuries (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy, Immunology and Transplantation Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on May 25, 2011 and posted on May 25, 2011.
- Applicants must submit their applications by Nov 2, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education County governments Private institutions of higher education State governments For profit organizations other than small businesses Independent school districts Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses City or township governments Public housing authorities/Indian housing authorities Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Organizations) are not eligible to apply. Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:
This funding opportunity (RFA-AI-11-033) is an NIH/National Institute of Allergy and Infectious Diseases (NIAID) call for R01 grant applications focused on predictive biodosimetry, specifically the discovery and development of biomarkers that can forecast both acute and delayed radiation injuries. The core public health and national security aim is to improve readiness for a radiological or nuclear terrorism event by enabling faster, more accurate triage and treatment decisions across the full civilian population. In practical terms, the program is looking for measurable biological indicators that help estimate exposure and, more importantly, predict clinical outcomes in different organs, tissues, or physiological systems, so that responders and clinicians can quickly identify who needs urgent intervention, who should be monitored for later complications, and how to prioritize limited medical resources during a mass-casualty scenario.
The scientific emphasis is on biomarkers that are useful for decision-making after an incident, not simply markers that change after radiation exposure. The opportunity highlights the need for indicators that can predict injury severity and timing, including immediate (acute) effects and later (delayed) consequences that may emerge after an initial stabilization period. Because the intended use is triage and prompt treatment decisions, the underlying expectation is that proposed biomarkers should have a realistic path toward operational use in emergency settings, meaning they should be measurable in ways that could eventually be translated into practical assays or platforms suitable for large-scale screening or clinical support. The announcement is oriented toward civilian preparedness, so the envisioned tools should work across diverse groups in the general population.
Mechanistically, this is a discretionary grant program using the R01 funding mechanism, which typically supports hypothesis-driven research and development efforts with substantial scientific depth. The overall estimated total funding listed for the announcement is $4,000,000, and the stated award ceiling is $250,000, indicating an upper limit on the amount that can be awarded per grant under this specific solicitation. Cost sharing or matching is explicitly not required, which lowers barriers for participation and keeps the focus on scientific merit and feasibility rather than institutional co-funding capacity.
Eligibility is broad and includes a wide range of U.S.-based organizations and government entities. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, with the noted exceptions), for-profit organizations (including small businesses and other than small businesses), and multiple levels of government such as state, county, city or township governments, independent school districts, special district governments, and public housing authorities/Indian housing authorities. The announcement also specifies eligibility for various mission- or community-focused institutions and organizations, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, tribally controlled colleges and universities (TCCUs), and faith-based or community-based organizations, along with regional organizations and U.S. territories or possessions. Non-U.S. (foreign) organizations are not eligible to apply as applicant institutions; however, foreign components of U.S. organizations are allowed, which can matter for projects that involve specialized assays, comparative datasets, or collaborations that include overseas laboratories under a U.S. prime applicant.
Key administrative details reflect that this was a time-limited solicitation. The opportunity was posted and created on May 25, 2011, with an original and current closing date of November 2, 2011, and an archive date of December 3, 2011. The CFDA program numbers associated with the funding are 93.855 (Allergy, Immunology and Transplantation Research) and 93.856 (Microbiology and Infectious Diseases Research), consistent with NIAID’s broader mission space while also reflecting the biodefense and emergency preparedness context in which radiation injury countermeasures and biodosimetry sit.
For applicants, the most important takeaway is that NIAID was seeking R01 projects that move the field toward actionable, predictive biomarkers for radiation injury outcomes, aimed at enabling triage and timely treatment after a radiological/nuclear incident affecting civilians at scale. The full announcement and official instructions were provided through the NIH Grants Guide link (http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-11-033.html), with NIH Office of Extramural Research (OER) webmaster contacts listed for technical access issues.
FAQs: NIH/NIAID R01 Funding Opportunity RFA-AI-11-033 (Predictive Biodosimetry)
What is this funding opportunity?
This is an NIH National Institute of Allergy and Infectious Diseases (NIAID) request for applications (RFA-AI-11-033) using the R01 grant mechanism to support research on predictive biodosimetry. The focus is on discovering and developing biomarkers that can forecast both acute (immediate) and delayed radiation injuries.
What is the main goal of the program?
The central goal is to improve public health readiness and national security preparedness for a radiological or nuclear terrorism event by enabling faster, more accurate triage and treatment decisions across the civilian population, especially in a mass-casualty setting where medical resources may be limited.
What does “predictive biodosimetry” mean in this announcement?
In the context of this solicitation, predictive biodosimetry refers to measurable biological indicators (biomarkers) that help estimate radiation exposure and, more importantly, predict clinical outcomes. The intent is to support decision-making about injury severity, which organs or systems may be affected, and when effects may occur (acute vs. delayed).
What kinds of biomarkers is NIAID looking for?
NIAID is looking for biomarkers that are useful for operational decision-making after an incident. The emphasis is on indicators that can predict injury severity and timing (including delayed consequences that may emerge after initial stabilization), not simply markers that change after radiation exposure.
Is the program interested in biomarkers for specific organs or systems?
Yes. The announcement highlights biomarkers that can predict clinical outcomes in different organs, tissues, or physiological systems, so responders and clinicians can better determine who needs urgent intervention and who should be monitored for later complications.
How are the biomarkers expected to be used after an incident?
The envisioned use is to support triage and prompt treatment decisions, including identifying people who need immediate care, people who can be monitored, and how to prioritize scarce medical resources during a mass-casualty scenario.
Does this opportunity prioritize practical, real-world use?
Yes. Because the intended use is emergency triage and treatment decision support, proposed biomarkers are expected to have a realistic path toward operational use. That implies they should be measurable in ways that could eventually be translated into practical assays or platforms suitable for large-scale screening or clinical support.
Who is the intended population for these tools?
The solicitation is oriented toward civilian preparedness. The tools are envisioned to work across diverse groups in the general population, consistent with large-scale, civilian mass-casualty response needs.
What funding mechanism is used?
This opportunity uses the NIH R01 mechanism, which generally supports substantial, hypothesis-driven research and development efforts with significant scientific depth.
How much total funding is associated with this opportunity?
The estimated total funding amount listed for the announcement is $4,000,000.
Is there an award ceiling (maximum award amount)?
Yes. The stated award ceiling is $250,000, indicating an upper limit on the amount that can be awarded per grant under this specific solicitation.
Is cost sharing or matching required?
No. Cost sharing or matching is explicitly not required.
What types of organizations are eligible to apply?
Eligibility is broad and includes many U.S.-based organizations and government entities, including:
- Public and private institutions of higher education
- Nonprofit organizations (including those with and without 501(c)(3) status, with noted exceptions in the announcement)
- For-profit organizations (including small businesses and other than small businesses)
- State, county, city or township governments
- Independent school districts
- Special district governments
- Public housing authorities / Indian housing authorities
- Faith-based or community-based organizations
- Regional organizations
- U.S. territories or possessions
Are minority-serving institutions specifically mentioned as eligible?
Yes. The announcement specifically notes eligibility for institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and tribally controlled colleges and universities (TCCUs).
Can foreign (non-U.S.) organizations apply as the main applicant?
No. Non-U.S. (foreign) organizations are not eligible to apply as applicant institutions under this opportunity.
Are foreign components allowed if the main applicant is a U.S. organization?
Yes. Foreign components of U.S. organizations are allowed, which may be relevant for projects involving specialized assays, comparative datasets, or collaborations with overseas laboratories under a U.S. prime applicant.
What are the key dates for this solicitation?
The opportunity was posted/created on May 25, 2011. The original and current closing date is November 2, 2011. The archive date is December 3, 2011.
Is this a currently open funding opportunity?
Based on the provided dates, the solicitation was time-limited and has been archived (archive date: December 3, 2011), with a closing date of November 2, 2011.
What CFDA program numbers are associated with this opportunity?
The CFDA program numbers listed are 93.855 (Allergy, Immunology and Transplantation Research) and 93.856 (Microbiology and Infectious Diseases Research).
Why are NIAID CFDA numbers used for a radiation injury biomarker program?
Within this announcement, the CFDA numbers reflect NIAID’s broader mission space while also aligning with biodefense and emergency preparedness activities where radiation injury countermeasures and biodosimetry are considered relevant.
What is the core public health and national security rationale?
The program is designed to strengthen readiness for radiological or nuclear terrorism by improving the ability to rapidly triage and treat large numbers of civilians, helping clinicians and responders make better decisions under urgent conditions and limited resources.
Where can applicants find the official announcement and instructions?
The full announcement and official instructions are available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-11-033.html
Who is listed for technical access issues related to the announcement?
NIH Office of Extramural Research (OER) webmaster contacts are listed for technical access issues.
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