Opportunity Information: Apply for PAR 10 163
Apply for PAR 10 163
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Preliminary Clinical Studies in Preparation for Large Interventional Trials of Complementary and Alternative Medicine (CAM) Therapies (R34)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health.
- This funding opportunity was created on Apr 6, 2010 and posted on Apr 6, 2010.
- Applicants must submit their applications by Sep 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $225,000.00 in funding.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses State governments Public and State controlled institutions of higher education County governments Private institutions of higher education Small businesses Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The funding opportunity PAR-10-163, titled "Preliminary Clinical Studies in Preparation for Large Interventional Trials of Complementary and Alternative Medicine (CAM) Therapies (R34)," is a National Institutes of Health (NIH) discretionary grant program issued through what was then the National Center for Complementary and Alternative Medicine (NCCAM). Its central aim is to move promising, high-priority complementary and alternative medicine interventions closer to readiness for large-scale human studies by funding early-phase clinical research and the practical development work that must happen before a major trial can be responsibly designed and launched. In other words, it is meant to help investigators build the tools, procedures, and preliminary human data needed to justify and properly plan a later, bigger and more definitive study, rather than to fund that definitive study itself.
A key point in this announcement is what the grant will and will not support. The R34 mechanism here is specifically described as not appropriate for randomized clinical trials that test or determine efficacy. Applicants are not supposed to use these funds to run a full-scale randomized controlled trial aimed at proving an intervention works. Instead, the emphasis is on preparatory clinical studies that inform the design of future research, including later randomized clinical trials, cluster randomized trials, or cohort studies. This typically includes work like refining or standardizing the intervention protocol, testing recruitment and retention strategies, establishing feasible dosing or delivery schedules, confirming the acceptability of procedures to participants, selecting and piloting outcome measures, checking adherence and fidelity monitoring plans, developing data collection and quality-control systems, estimating variability and effect-size signals for future power calculations, and addressing practical issues that commonly derail larger trials if not resolved early.
The announcement also highlights that these preliminary studies may contribute to the design of either efficacy studies (tightly controlled trials asking whether an intervention can work under ideal conditions) or real-world effectiveness studies (pragmatic approaches asking whether an intervention works in typical clinical or community settings). That framing is important because it signals that NIH is open to early-stage work that clarifies which type of future trial is most appropriate and what design features are needed to make it scientifically credible and operationally realistic.
From an administrative and funding perspective, this opportunity uses the NIH R34 grant mechanism, which is commonly positioned as a planning and preliminary clinical studies award. The listed award ceiling is $225,000. Awards are contingent on the availability of funds and on receiving a sufficient number of highly meritorious applications, meaning there is no guaranteed number of awards; funding depends on both budget conditions and competitive review outcomes.
Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants include nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), public and private institutions of higher education, and a wide range of governmental entities such as state governments, county governments, city or township governments, special district governments, and independent school districts. The opportunity also explicitly includes tribal governments (federally recognized and other than federally recognized), tribal organizations, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, historically black colleges and universities (HBCUs), Hispanic-serving institutions, public housing authorities/Indian housing authorities, U.S. territories or possessions, regional organizations, eligible federal agencies, and faith-based or community-based organizations. It also states that non-domestic (non-U.S.) entities (foreign organizations) are eligible, which can matter for CAM interventions with origins, widespread use, or research capacity outside the United States.
There is no cost sharing or matching requirement, so applicants are not required to provide non-federal matching funds as a condition of the award. The program is associated with CFDA number 93.213, "Research and Training in Complementary and Integrative Health," reflecting its placement within NIH's portfolio for complementary and integrative health research.
Timing details in the source data indicate the opportunity was posted and created on April 6, 2010, with an original and current closing date of September 7, 2013, and an archive date of October 8, 2013. Practically speaking, those dates mean this specific announcement is no longer open, but the summary still captures how NIH structured this R34 mechanism for CAM at the time and what it sought to accomplish in terms of building a rigorous bridge between early clinical development and later definitive trials.
For more detail, the announcement points to the NIH Grants Guide page (http://grants.nih.gov/grants/guide/pa-files/PAR-10-163.html). For technical issues accessing the announcement, the listed contact is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
FAQs: PAR-10-163 - Preliminary Clinical Studies in Preparation for Large Interventional Trials of CAM Therapies (R34)
What is PAR-10-163?
PAR-10-163 is an NIH discretionary grant opportunity titled "Preliminary Clinical Studies in Preparation for Large Interventional Trials of Complementary and Alternative Medicine (CAM) Therapies (R34)." It was issued through what was then the National Center for Complementary and Alternative Medicine (NCCAM).
What is the main purpose of this R34 funding opportunity?
The central aim is to move promising, high-priority CAM interventions closer to readiness for large-scale human studies. It supports early-phase clinical research and the practical development work needed to responsibly design and launch a later, larger interventional trial.
Is this grant meant to fund a full-scale clinical trial?
No. This R34 is described as not appropriate for randomized clinical trials that test or determine efficacy. The intent is to fund preparatory studies that inform the design of future research rather than fund the definitive, full-scale trial itself.
What kinds of studies does this opportunity support?
It supports preliminary clinical studies and practical preparation activities that help researchers plan a larger study. Examples mentioned include refining or standardizing the intervention protocol, testing recruitment and retention approaches, establishing feasible dosing or delivery schedules, and confirming participant acceptability of procedures.
What specific preparatory activities are highlighted as a good fit?
The announcement emphasizes activities such as selecting and piloting outcome measures, checking adherence and fidelity monitoring plans, developing data collection and quality-control systems, estimating variability and effect-size signals to support later power calculations, and addressing practical issues that commonly derail larger trials if they are not resolved early.
Can the preliminary work supported here inform different types of future studies?
Yes. The announcement notes that these preliminary studies may contribute to the design of future efficacy studies (more tightly controlled, "can it work" conditions) or effectiveness studies (more real-world, pragmatic "does it work in typical settings" conditions).
Does NIH indicate what the later, larger studies could be?
Yes. The opportunity notes that the preparatory work may inform the design of later randomized clinical trials, cluster randomized trials, or cohort studies.
What grant mechanism is used?
This opportunity uses the NIH R34 mechanism, which is commonly positioned as a planning and preliminary clinical studies award.
What is the funding cap for this R34?
The listed award ceiling is $225,000.
Is funding guaranteed if an application is submitted?
No. Awards are contingent on the availability of funds and on receiving a sufficient number of highly meritorious applications. This means funding depends on both budget conditions and competitive review outcomes.
Who is eligible to apply?
Eligibility is broad. Eligible applicants include nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), public and private institutions of higher education, and a wide range of governmental entities (state, county, city/township, special district governments, and independent school districts).
Are tribal entities eligible?
Yes. The opportunity explicitly includes tribal governments (federally recognized and other than federally recognized), tribal organizations, and tribally controlled colleges and universities (TCCUs).
Are minority-serving institutions and specific community-serving institutions included in eligibility?
Yes. The announcement explicitly includes Alaska Native and Native Hawaiian serving institutions, historically black colleges and universities (HBCUs), Hispanic-serving institutions, and public housing authorities/Indian housing authorities.
Are U.S. territories or regional organizations eligible?
Yes. U.S. territories or possessions and regional organizations are explicitly included as eligible applicants.
Can federal agencies apply?
Yes. The opportunity lists eligible federal agencies among eligible applicants.
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are explicitly listed as eligible.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The opportunity states that non-domestic (non-U.S.) entities (foreign organizations) are eligible.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement, so applicants are not required to provide non-federal matching funds as a condition of the award.
What CFDA number is associated with this program?
The program is associated with CFDA number 93.213, "Research and Training in Complementary and Integrative Health."
When was this opportunity posted and when did it close?
The timing details indicate it was posted and created on April 6, 2010. The original and current closing date listed is September 7, 2013, and the archive date is October 8, 2013.
Is PAR-10-163 currently open for applications?
No. Based on the listed closing and archive dates, this specific announcement is no longer open.
Where can applicants find the official announcement text?
The announcement points to the NIH Grants Guide page at http://grants.nih.gov/grants/guide/pa-files/PAR-10-163.html.
Who should be contacted for technical issues accessing the announcement?
For technical issues accessing the announcement, the listed contact is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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