Opportunity Information: Apply for RFA HL 16 015
Apply for RFA HL 16 015
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Prematurity Related Ventilatory Control (Pre Vent) Role in Respiratory Outcomes Clinical Research Centers (CRC) (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research.
- This funding opportunity was created on Jun 5, 2015 and posted on Jun 5, 2015.
- Applicants must submit their applications by Oct 20, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Special district governments Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Independent school districts County governments Private institutions of higher education Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Prematurity Related Ventilatory Control (Pre Vent) Role in Respiratory Outcomes Clinical Research Centers (CRC) opportunity (RFA-HL-16-015) is a National Institutes of Health, National Heart, Lung, and Blood Institute (NHLBI) funding announcement that supports participation in a multicenter clinical research effort focused on premature infants and respiratory control. The award mechanism is a U01 cooperative agreement, which means the funded sites are expected to work closely with NHLBI and other program components under a cooperative, team-science structure rather than operating as fully independent investigator-initiated projects. In practical terms, the funded institutions serve as Clinical Research Centers (CRCs) responsible for conducting the on-the-ground clinical and research activities required by the program.
The core scientific purpose of the program is to understand why premature infants often experience unstable oxygenation and disordered breathing, both during their stay in the Neonatal Intensive Care Unit (NICU) and after discharge, and how these problems relate to later respiratory illness and risk of serious outcomes. The announcement highlights ventilatory control mechanisms as the central theme, including factors such as chemoreceptor control (how the body senses and responds to oxygen and carbon dioxide), mechanoreceptor inputs (feedback from the lungs and airways), and developmental influences on the immature respiratory system. By studying these mechanisms in a structured way, the program aims to clarify how ventilatory instability contributes to morbidity and mortality in this highly vulnerable population.
The research approach described is a prospective observational cohort design. That means participating CRCs enroll premature infants and follow them forward in time, collecting standardized clinical and physiologic information without assigning experimental treatments as part of the core study design. The intent is to build a detailed picture of how ventilatory control and oxygenation patterns evolve during and after NICU care, and how early-life physiologic signatures relate to later outcomes. The long-term objective is not just descriptive; it is to generate stronger insight into the pathogenesis of chronic respiratory disease in children born prematurely and to identify plausible targets for prevention and future therapies. In other words, the program is positioned as a foundation-building effort that can inform the next generation of interventions aimed at improving lifelong respiratory health.
From a funding and administrative standpoint, this is a discretionary health research opportunity with no cost sharing or matching requirement. NHLBI expected to make about five awards under this announcement. The relevant CFDA listing provided is 93.838 (Lung Diseases Research). The funding opportunity was posted on June 5, 2015, with an original and current closing date of October 20, 2015, and an archive date of November 20, 2015, indicating the specific solicitation is no longer open but remains useful as a reference for similar future initiatives.
Eligibility is broad across U.S.-based organizations. Eligible applicants include public and private institutions of higher education, nonprofits with or without 501(c)(3) status (with the noted exception language in the listing), for-profit organizations other than small businesses, small businesses, and multiple levels of government (state, county, city/township, special district), as well as public housing authorities and independent school districts. The announcement also explicitly includes a range of mission-focused institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander-Serving Institutions (AANAPISIs), along with faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Non-U.S. (foreign) institutions and non-U.S. components of U.S. organizations are not eligible to apply, although foreign components may be allowed consistent with NIH policy definitions.
Operationally, a CRC applying under this announcement would be proposing to function as a clinical site within the Pre Vent observational program, contributing to participant enrollment and follow-up and implementing program-wide procedures to ensure comparable, high-quality data across sites. Because it is a cooperative agreement, expectations typically include active collaboration, adherence to common protocols, and participation in cross-site governance and reporting activities coordinated with NHLBI. The announcement provides an NIH link for the full details and directs technical access questions to the NIH Office of Extramural Research (OER) webmaster contact.
Frequently Asked Questions (FAQs)
What is the Prematurity Related Ventilatory Control (Pre Vent) Clinical Research Centers (CRC) opportunity?
It is a National Institutes of Health (NIH) funding announcement from the National Heart, Lung, and Blood Institute (NHLBI) titled "Prematurity Related Ventilatory Control (Pre Vent) Role in Respiratory Outcomes Clinical Research Centers (CRC)" (RFA-HL-16-015). It supports participation in a multicenter clinical research effort focused on premature infants and respiratory control.
What is the main scientific focus of this program?
The program focuses on understanding why premature infants often have unstable oxygenation and disordered breathing during their Neonatal Intensive Care Unit (NICU) stay and after discharge, and how these issues relate to later respiratory illness and risk of serious outcomes. Ventilatory control mechanisms are a central theme.
What does "ventilatory control" refer to in this announcement?
Ventilatory control refers to mechanisms involved in regulating breathing and oxygenation, including chemoreceptor control (how the body senses and responds to oxygen and carbon dioxide), mechanoreceptor inputs (feedback from the lungs and airways), and developmental influences on the immature respiratory system.
What type of study design is described?
The announcement describes a prospective observational cohort design. Participating sites enroll premature infants and follow them forward in time, collecting standardized clinical and physiologic information without assigning experimental treatments as part of the core study design.
Does this opportunity fund clinical trials or treatment interventions?
Based on the description provided, the core research approach is observational and does not assign experimental treatments as part of the core study design.
What are the intended outcomes or goals of collecting these data?
The goal is to build a detailed picture of how ventilatory control and oxygenation patterns evolve during and after NICU care, and how early-life physiologic signatures relate to later outcomes. The longer-term objective is to strengthen understanding of the pathogenesis of chronic respiratory disease in children born prematurely and to identify plausible targets for prevention and future therapies.
What is the award mechanism for this funding opportunity?
The award mechanism is a U01 cooperative agreement.
What does a U01 cooperative agreement mean for funded sites?
A U01 cooperative agreement indicates that funded sites are expected to work closely with NHLBI and other program components under a cooperative, team-science structure rather than operating as fully independent investigator-initiated projects.
What role does a funded institution play under this announcement?
Funded institutions serve as Clinical Research Centers (CRCs) responsible for conducting on-the-ground clinical and research activities required by the program. This includes enrolling participants, conducting follow-up, and implementing program-wide procedures to ensure comparable, high-quality data across sites.
What kinds of collaboration and coordination are expected from CRCs?
Because this is a cooperative agreement, expectations typically include active collaboration, adherence to common protocols, and participation in cross-site governance and reporting activities coordinated with NHLBI.
Is cost sharing or matching required?
No. The opportunity is described as having no cost sharing or matching requirement.
How many awards did NHLBI expect to make?
NHLBI expected to make about five awards under this announcement.
What is the CFDA number associated with this opportunity?
The CFDA listing provided is 93.838 (Lung Diseases Research).
When was this funding opportunity posted and when did it close?
The opportunity was posted on June 5, 2015. The original and current closing date was October 20, 2015. The archive date was November 20, 2015.
Is this specific solicitation still open for applications?
No. The closing and archive dates indicate this specific solicitation is no longer open, though it may still be useful as a reference for similar future initiatives.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations. Eligible applicants include public and private institutions of higher education, nonprofits with or without 501(c)(3) status (with the noted exception language in the listing), for-profit organizations other than small businesses, small businesses, and multiple levels of government (state, county, city/township, special district). Public housing authorities and independent school districts are also included.
Are mission-focused institutions specifically included in the eligibility list?
Yes. The announcement explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American and Native American Pacific Islander-Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies.
Can non-U.S. (foreign) institutions apply?
No. Non-U.S. (foreign) institutions and non-U.S. components of U.S. organizations are not eligible to apply. However, foreign components may be allowed consistent with NIH policy definitions.
What population is the research focused on?
The research focuses on premature infants, particularly examining breathing control and oxygenation instability during NICU care and after discharge.
What are examples of the types of issues in premature infants that the program aims to understand?
The announcement highlights unstable oxygenation and disordered breathing, and how these problems may connect to later respiratory illness and risk of serious outcomes, including morbidity and mortality in this vulnerable population.
What does it mean that the program is a multicenter clinical research effort?
It means multiple funded Clinical Research Centers participate as coordinated sites, using standardized procedures and collaborating under a shared structure with NHLBI involvement to support comparable, high-quality data collection across sites.
Where can applicants find full details or get technical help?
The announcement provides an NIH link for full details and directs technical access questions to the NIH Office of Extramural Research (OER) webmaster contact.
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